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IWP-2 - ≥98%, high purity , CAS No.686770-61-6

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
I126927
Grouped product items
SKU Size
Availability
 Price Qty
I126927-5mg
5mg
3
$53.90
I126927-10mg
10mg
3
$86.90
I126927-25mg
25mg
2
$173.90
I126927-50mg
50mg
2
$282.90
I126927-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$445.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

PORCN inhibitor; inhibits Wnt processing and secretion

View related series
Casein Kinase (72) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Porcupine (8) Regenerative medicine research reagents (17) Stem cell biology (6) Stem Cell/Wnt (1019) Wnt (104)

Basic Description

Synonyms BDBM50428028 | HMS3652J22 | IWP-2, >=98% (HPLC) | CID 2155128 | EX-A2264 | N -(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrimidin-2-yl)thio]-acetamide | Z2235802202 | N-(6-Methylbenzo[d]thiazol-2-yl)-2-(4-oxo-3-phenyl
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Inhibitor of Wnt processing and secretion. Inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, andβ-catenin accumulation. Suppresses
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses.
An inhibitor of Wnt production


Application

IWP-2 has been used to treat the cell lines L-Wnt-3a and L-Wnt-5a, to demonstrate the inhibitory effect of IWP-2. It has also been used as a Wnt signaling inhibitor to treat WT and Gja1Jrt/+ stromal cells to confirm that, theWnt/β-catenin signaling pathway pathway was not involved in the increased marker expression by Gja1Jrt/+ osteoblasts.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Thienopyrimidines
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Thienopyrimidines
Alternative Parents Benzothiazoles  N-arylamides  Pyrimidones  Alkylarylthioethers  Benzene and substituted derivatives  Thiazoles  Heteroaromatic compounds  Secondary carboxylic acid amides  Lactams  Sulfenyl compounds  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents 1,3-benzothiazole - Thienopyrimidine - Aryl thioether - N-arylamide - Pyrimidone - Alkylarylthioether - Monocyclic benzene moiety - Pyrimidine - Benzenoid - Azole - Heteroaromatic compound - Thiazole - Carboxamide group - Lactam - Secondary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Sulfenyl compound - Thioether - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Carbonyl group - Organopnictogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as thienopyrimidines. These are heterocyclic compounds containing a thiophene ring fused to a pyrimidine ring. Thiophene is 5-membered ring consisting of four carbon atoms and one sulfur atom. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
External Descriptors Not available

Associated Targets(Human)

PORCN Tchem Protein-serine O-palmitoleoyltransferase porcupine (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK1E Tclin Casein kinase I epsilon (1412 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ZAP70 Tchem Tyrosine-protein kinase ZAP-70 (2189 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAPAN-1 (772 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PANC-1 (6144 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SW-620 (52400 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TLK2 Tchem Serine/threonine-protein kinase tousled-like 2 (710 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PORCN Tchem Probable protein-cysteine N-palmitoyltransferase porcupine (135 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Soat1 Acyl coenzyme A:cholesterol acyltransferase 1 (295 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Jun Transcription factor AP-1 (36 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Wnt3a Protein Wnt-3a (429 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Danio rerio (3092 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mboat4 Ghrelin O-acyltransferase (37 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mboat1 Lysophospholipid acyltransferase 1 (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hhat Protein-cysteine N-palmitoyltransferase HHAT (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mboat2 Lysophospholipid acyltransferase 2 (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Lpcat3 Lysophospholipid acyltransferase 5 (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504760703
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504760703
IUPAC Name N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide
INCHI InChI=1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
InChIKey WRKPZSMRWPJJDH-UHFFFAOYSA-N
Smiles CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4
Isomeric SMILES CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4
WGK Germany 2
Molecular Weight 466.6
Reaxy-Rn 19908773
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19908773&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
A2211790 Certificate of Analysis Oct 11, 2023 I126927
A2211853 Certificate of Analysis Oct 11, 2023 I126927
A2211868 Certificate of Analysis Oct 11, 2023 I126927
A2211804 Certificate of Analysis Oct 11, 2023 I126927
A2211836 Certificate of Analysis Oct 11, 2023 I126927

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 2.33, Max Conc. mM: 5 with gentle warming
Sensitivity heat sensitive
Boil Point(°C) 723.12° C
Melt Point(°C) 316.82°C
Molecular Weight 466.600 g/mol
XLogP3 4.800
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 5
Exact Mass 466.059 Da
Monoisotopic Mass 466.059 Da
Topological Polar Surface Area 154.000 Ų
Heavy Atom Count 31
Formal Charge 0
Complexity 796.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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