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IV-361 - 98%, high purity , CAS No.2055741-39-2

COA

Grade & Purity:

≥98%

Cas Number: 2055741-39-2
Molecular Weight: 457.62

In stock

Item Number

I649000

Grouped product items
SKU	Size	Availability	Price	Qty
I649000-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,050.90
I649000-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,650.90

View related series

CDK (252) Cell Cycle (2830) Cell Cycle/DNA Damage (2602)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	IV-361 is an orally active and selective CDK7 inhibitor ( K i ≤50 nM). IV-361 has anti-cancer activity (US20190256531A1).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	IV-361 is an orally active and selective CDK7 inhibitor ( K i ≤50 nM). IV-361 has anti-cancer activity (US20190256531A1) In Vitro IV-361 has less inhibition on CDK2 (K i ≥1000 nM) or PLK1 (K i ≥5000 nM). IV-361 exhibits excellent IL-2 and IL-17 production inhibitory activity (all IC 50 ≤100 nM) in periphery blood mononuclear cell (PBMC). IV-361 exhibits excellent HCT-116 cell growth inhibitory activity (GI 50 ≤100 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo IV-361 (25 mg/kg/day; orally) exhibits 46% or more rate of suppression of tumor volume in female BALB nude mice with HCT-116 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CDK7 ≤50 nM (Ki) CDK2 ≥1000 nM (Ki)

Names and Identifiers

Smiles	O=C(N(C1)C(C)(C)C2=C1C(NC(C3([Si](C)(C)C)CCC3)=O)=NN2)NC4=CC(F)=CC=C4C
Molecular Weight	457.62

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

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