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Iodoacetamide - 98%, high purity , CAS No.144-48-9, Activator of TRPA1

71 Citations COA COA
In stock
Item Number
I105563
Grouped product items
SKU Size
Availability
 Price Qty
I105563-5g
5g
3
$13.90
I105563-10g
10g
2
$23.90
I105563-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$52.90
I105563-100g
100g
1
$159.90
I105563-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$549.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Cell Cycle/DNA Damage (2602) DNA Alkylator/Crosslinker (72) DNA Damage (697) TRPA1 Activator (39)

Basic Description

Synonyms A808220 | Iodoacetamide, >=98.0% (AT), purum | Iodoacetamide, Single use vial of 56 mg | SCHEMBL20371 | 1219802-64-8 | PGLTVOMIXTUURA-UHFFFAOYSA- | WLN: ZV1I | BDBM50376514 | GTPL6271 | IODOACETAMIDE-D4 | NCGC00015548-06 | NCGC00093954-01 | alpha-Iodoacet
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for
Storage Temp Store at 2-8°C,Protected from light
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type ACTIVATOR
Mechanism of action Activator of TRPA1
Product Description

Alkylating reagent for cysteine residues in peptide sequencing.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Carboxylic acid derivatives
Intermediate Tree Nodes Carboxylic acid amides
Direct Parent Primary carboxylic acid amides
Alternative Parents Organopnictogen compounds  Organonitrogen compounds  Organoiodides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  Alkyl iodides  
Molecular Framework Aliphatic acyclic compounds
Substituents Primary carboxylic acid amide - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organoiodide - Organohalogen compound - Carbonyl group - Alkyl iodide - Alkyl halide - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as primary carboxylic acid amides. These are compounds comprising primary carboxylic acid amide functional group, with the general structure RC(=O)NH2.
External Descriptors an iodide

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TYMS Tclin Thymidylate synthase (1651 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AK2 Tbio Adenylate kinase 2 (264 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
F13A1 Tchem Coagulation factor XIII (223 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
USP2 Tbio Ubiquitin carboxyl-terminal hydrolase 2 (8818 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
THPO Tbio Thrombopoietin (834 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ATG4B Tchem Cysteine protease ATG4B (985 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADH1A Tclin Alcohol dehydrogenase (35 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Saccharomyces cerevisiae (19171 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
crtY Lycopene cyclase (9 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2-iodoacetamide
INCHI InChI=1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
InChIKey PGLTVOMIXTUURA-UHFFFAOYSA-N
Smiles C(C(=O)N)I
Isomeric SMILES C(C(=O)N)I
WGK Germany 3
RTECS AC4200000
UN Number 2811
Packing Group III
Molecular Weight 184.96
Beilstein 1739080
Reaxy-Rn 1739080
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1739080&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

44 results found

Lot Number Certificate Type Date Item
F2518379 Certificate of Analysis Jun 24, 2025 I105563
F2518380 Certificate of Analysis Jun 24, 2025 I105563
F2518408 Certificate of Analysis Jun 24, 2025 I105563
F2518409 Certificate of Analysis Jun 24, 2025 I105563
F2518410 Certificate of Analysis Jun 24, 2025 I105563
F2518411 Certificate of Analysis Jun 24, 2025 I105563
I2304350 Certificate of Analysis Jun 10, 2025 I105563
L2406462 Certificate of Analysis Oct 22, 2024 I105563
L2406463 Certificate of Analysis Oct 22, 2024 I105563
L2406464 Certificate of Analysis Oct 22, 2024 I105563
L2406530 Certificate of Analysis Oct 22, 2024 I105563
F2411237 Certificate of Analysis May 16, 2024 I105563
F2411238 Certificate of Analysis May 16, 2024 I105563
I2406219 Certificate of Analysis May 16, 2024 I105563
F2411236 Certificate of Analysis May 16, 2024 I105563
F2411239 Certificate of Analysis May 16, 2024 I105563
K2330114 Certificate of Analysis Nov 17, 2023 I105563
E2408061 Certificate of Analysis Nov 17, 2023 I105563
K2330110 Certificate of Analysis Nov 17, 2023 I105563
K2330108 Certificate of Analysis Nov 17, 2023 I105563
K2330112 Certificate of Analysis Nov 17, 2023 I105563
I2304340 Certificate of Analysis Aug 18, 2023 I105563
I2304385 Certificate of Analysis Aug 18, 2023 I105563
F2305295 Certificate of Analysis May 24, 2023 I105563
F2305294 Certificate of Analysis May 24, 2023 I105563
F2305296 Certificate of Analysis May 24, 2023 I105563
D2418049 Certificate of Analysis May 24, 2023 I105563
G2311061 Certificate of Analysis May 10, 2023 I105563
F2305292 Certificate of Analysis May 10, 2023 I105563
F2305293 Certificate of Analysis May 10, 2023 I105563
F2305285 Certificate of Analysis May 10, 2023 I105563
K2224520 Certificate of Analysis Nov 21, 2022 I105563
D2320040 Certificate of Analysis Nov 21, 2022 I105563
E2310060 Certificate of Analysis Nov 21, 2022 I105563
K2224516 Certificate of Analysis Nov 21, 2022 I105563
K2224518 Certificate of Analysis Nov 21, 2022 I105563
K2224517 Certificate of Analysis Nov 21, 2022 I105563
H2215146 Certificate of Analysis Jun 05, 2022 I105563
H2215147 Certificate of Analysis Jun 05, 2022 I105563
H2215145 Certificate of Analysis Jun 05, 2022 I105563
H2215144 Certificate of Analysis Jun 05, 2022 I105563
F2201266 Certificate of Analysis May 24, 2022 I105563
E2220212 Certificate of Analysis May 24, 2022 I105563
C2208137 Certificate of Analysis Mar 15, 2022 I105563

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Chemical and Physical Properties

Solubility Soluble in water; Soluble in Methanol
Sensitivity Light & Moisture Sensitive
Melt Point(°C) 95°C
Molecular Weight 184.960 g/mol
XLogP3 -0.200
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 1
Rotatable Bond Count 1
Exact Mass 184.934 Da
Monoisotopic Mass 184.934 Da
Topological Polar Surface Area 43.100 Ų
Heavy Atom Count 5
Formal Charge 0
Complexity 44.900
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

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