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Integrin beta 7 Rat mAb - Primary antibody, specific to Integrin beta 7, Rat IgG2a

COA COA
    Application:
  • Animal Model
  • Blocking
  • Flow Cytometry
  • Functional Assay
  • IP
  • WB
  • Host species: Rat
  • Reactive species: Human,Mouse
  • Isotype: Rat IgG2a
  • Clone Number: FIB504
  • Conjugation: Unconjugated
In stock
Item Number
Ab110906
Grouped product items
SKU Size
Availability
 Price Qty
Ab110906-10μg
10μg
10
$29.90
Ab110906-50μg
50μg
4
$69.90
Ab110906-100μg
100μg
2
$99.90
Ab110906-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$229.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (FIB504); Rat anti Human/Mouse Integrin beta 7 Antibody; Flow, IP, WB, in vivo blocking of integrin β7; Unconjugated

View related series
Click to view target information: ITGB7
Accession#: P26011 (6) Accession#:P26010 (9) Flow Cytometry (1158) Gene ID: 16421 (6) Gene ID:3695 (9) Integrin beta 7 (2) Ly69 (6)

Basic Description

Product Name Integrin beta 7 Rat mAb - Primary antibody, specific to Integrin beta 7, Rat IgG2a
Synonyms Diethanolglycine | N,N-Di(2-hydroxyethyl)glycine | Ly69 | Gut homing receptor beta subunit | integrin beta 7 subunit | Integrin beta 7 | integrin beta-7 | integrin, beta 7 | ITGB7 | Gut homing receptor beta subunit antibody | Integrin beta 7 subunit antib
Specifications & Purity Carrier Free, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Rat
Specificity Integrin beta 7
Immunogen TK1 cells
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Rat anti Human/Mouse Integrin beta 7 Antibody, Monoclonal (FIB504), could be used for Flow, IP, WB, in vivo blocking of integrin β7 and so on.

Application

Flow: Use at an assay dependent concentration.

IP: Use at an assay dependent concentration.

WB: Use at an assay dependent concentration.

in vivo blocking of integrin β7: Use at an assay dependent concentration.
Protein Function
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Product Properties

Isotype Rat IgG2a
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

ITGB7 Tclin Integrin beta-7 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Integrin beta 7 Rat mAb (Ab110906) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling Integrin beta 7 with Integrin beta 7 Rat mAb (Ab110906) conjugated with biotin (right panel) at 0.5 μg/mL for 1 hour at 4°C, compared with Rat IgG Isotype Control Antibody (Biotin) (Ab180310) (left panel) and detected with SA-PE (rp156150). 

Integrin beta 7 Rat mAb (Ab110906) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling Integrin beta 7 (red) with Integrin beta 7 Rat mAb (Ab110906) conjugated with biotin at 0.5 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Rat IgG Isotype Control Antibody (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.

Application

Application Dilution info
WB

Use at an assay dependent concentration.
IP

Use at an assay dependent concentration.
Flow Cytometry

Use at an assay dependent concentration.
in vivo blocking of integrin β7

Use at an assay dependent concentration

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0607439 Certificate of Analysis Mar 26, 2025 Ab110906
ZJ24F0607438 Certificate of Analysis Jun 26, 2024 Ab110906
ZJ24F0607437 Certificate of Analysis Jun 26, 2024 Ab110906

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