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INH1 - ≥98%, high purity , CAS No.313553-47-8

COA

Grade & Purity:

≥98%

Cas Number: 313553-47-8
Molecular Weight: 308.40
PubChem CID: 959043
PubChem SID: 504760326

In stock

Item Number

I341876

Grouped product items
SKU	Size	Availability	Price
I341876-10mg	10mg	3	$141.90
I341876-50mg	50mg	3	$606.90
I341876-100mg	100mg	2	$1,090.90
I341876-250mg	250mg	2	$2,454.90

View related series

Apoptosis (4276) Cell Cycle (2830)

Basic Description

Synonyms	Benzamide,N-[4-(2,4-dimethylphenyl)-2-thiazolyl]- \| INH1 \| LM-3287 \| N-(4-(2,4-dimethylphenyl) -2-thiazolyl)benzamide \| AC-33047 \| HY-16660 \| Q18350699 \| N-(4-(2,4-dimethylphenyl)thiazol-2-yl)benzamide \| CCG-267565 \| MFCD01356769 \| N-[4-(2,4-dimethylpheny
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Inhibitor that binds Hec1, inhibiting its association with Nek2 and kinetochores. Causes arrest of mitosis and inhibits proliferation in breast cancer cell lines (GI50= 10-20 μM). Shown to induce a transient mitotic arrest in HeLa cultures and inhibit the proliferation of 10 breast cancer cell lines (GI50 of 10-21 µM) as well as the cervical HeLa and colon HCT116 cancer lines, while exhibiting reduced potency against the noncancerous MCF10A line (GI50 = 41 µM). Reported to suppress the MDA-MB-468-derived tumor growth (by ~53% and ~75% 3 wks after a 7-wk treatment period with 50 mg/kg and 100 mg/kg INH1, repectively, i.p.) in a murine breast cancer model in vivo.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Benzoic acids and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Benzoic acids and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Benzamides
Alternative Parents	m-Xylenes Benzoyl derivatives 2,4-disubstituted thiazoles Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Benzamide - Benzoyl - Xylene - M-xylene - 2,4-disubstituted 1,3-thiazole - Azole - Thiazole - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as benzamides. These are organic compounds containing a carboxamido substituent attached to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

K562 (73714 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-468 (9477 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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NDC80 Tbio Kinetochore protein NDC80 homolog (14 Activities)

Discover Target: NDC80

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504760326
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504760326
IUPAC Name	N-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]benzamide
INCHI	InChI=1S/C18H16N2OS/c1-12-8-9-15(13(2)10-12)16-11-22-18(19-16)20-17(21)14-6-4-3-5-7-14/h3-11H,1-2H3,(H,19,20,21)
InChIKey	JPMOKRWIYQGMJL-UHFFFAOYSA-N
Smiles	CC1=CC(=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=CC=C3)C
Isomeric SMILES	CC1=CC(=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=CC=C3)C
Molecular Weight	308.40
Reaxy-Rn	12029081
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12029081&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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4 results found

Lot Number	Certificate Type	Date	Item
I2216225	Certificate of Analysis	Jun 10, 2025	I341876
I2216221	Certificate of Analysis	Jun 10, 2025	I341876
I2216224	Certificate of Analysis	Jun 10, 2025	I341876
I2216222	Certificate of Analysis	Jun 10, 2025	I341876

Chemical and Physical Properties

Solubility	DMSO (100mM) and ethanol (10mM)
Molecular Weight	308.400 g/mol
XLogP3	4.500
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	308.098 Da
Monoisotopic Mass	308.098 Da
Topological Polar Surface Area	70.200 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	383.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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INH1 - ≥98%, high purity , CAS No.313553-47-8

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

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