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Ieramilimab (anti-LAG3) - Primary antibody, specific to LAG3, Human IgG4SP, INHIBITOR of Lymphocyte activation gene 3 protein inhibitor, INHIBITOR of Lymphocyte activation gene 3 protein inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab182825
Grouped product items
SKU Size
Availability
Price Qty
Ab182825-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab182825-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$259.90
Ab182825-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$649.90
Ab182825-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,029.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Ieramilimab (anti-LAG3) - Primary antibody, specific to LAG3, Human IgG4SP, INHIBITOR of Lymphocyte activation gene 3 protein inhibitor
Synonyms CD223 antibody | CD223 antigen antibody | FDC protein antibody | LAG-3 antibody | Lag3 antibody | LAG3_HUMAN antibody | Lymphocyte activating 3 antibody | Lymphocyte activation gene 3 antibody | Lymphocyte activation gene 3 protein antibody | Protein FDC
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity LAG3
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Lymphocyte activation gene 3 protein inhibitor
Product Description

Ieramilimab (anti-LAG3) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.7 kDa (Light Chain) & 53.0 kDa (Heavy Chain), under reducing conditions; 199.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2137049-37-5

Associated Targets(Human)

LAG3 Tclin Lymphocyte activation gene 3 protein (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Ieramilimab (anti-LAG3) (Ab182825) - ELISA
Immobilized Recombinant Human LAG-3 (C-6His) at 2.0 μg/mL can bind ieramilimab with the EC50 is 388.6 ng/mL.

Ieramilimab (anti-LAG3) (Ab182825) - SEC
The purity of Ieramilimab (anti-LAG3) (Ab182825) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0809237 Certificate of Analysis Aug 05, 2024 Ab182825
ZJ24F0809236 Certificate of Analysis Aug 05, 2024 Ab182825
ZJ24F0809235 Certificate of Analysis Aug 05, 2024 Ab182825

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