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Heptafluorobutyric acid - 98%, high purity , CAS No.375-22-4

    Grade & Purity:
  • ≥98%
In stock
Item Number
H106257
Grouped product items
SKU Size
Availability
Price Qty
H106257-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$14.90
H106257-25g
25g
1
$22.90
H106257-100g
100g
1
$146.90
H106257-500g
500g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$512.90

Basic Description

Synonyms HFBA | Perfluorobutanoic acid | Kyselina heptafluormaselna | NSC 820 | J-521427 | NSC820 | NSC-820 | Perfluoro-n-butanoic acid | PFBA | STR03803
Specifications & Purity ≥98%
Storage Temp Argon charged
Shipped In Normal
Product Description

Heptafluorobutyric acid is an anion-pairing agent for reverse phase HPLC purification of proteins and peptides.
An anion-pairing agent for reverse phase HPLC purification of proteins & peptides.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organohalogen compounds
Class Alkyl halides
Subclass Alkyl fluorides
Intermediate Tree Nodes Not available
Direct Parent Perfluoroalkyl carboxylic acid and derivatives
Alternative Parents Halogenated fatty acids  Alpha-halocarboxylic acids  Monocarboxylic acids and derivatives  Carboxylic acids  Organofluorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic acyclic compounds
Substituents Perfluoroalkyl carboxylic acid or derivatives - Halogenated fatty acid - Fatty acyl - Fatty acid - Alpha-halocarboxylic acid - Alpha-halocarboxylic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organic oxide - Organofluoride - Organooxygen compound - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as perfluoroalkyl carboxylic acid and derivatives. These are organic compounds containing an alkyl chain attached to the C-alpha of a carboxylic acid group (or a derivative thereof), where all hydrogens of the alkyl chain are replaced by fluorine atoms.
External Descriptors organofluorine compound - monocarboxylic acid

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2,2,3,3,4,4,4-heptafluorobutanoic acid
INCHI InChI=1S/C4HF7O2/c5-2(6,1(12)13)3(7,8)4(9,10)11/h(H,12,13)
InChIKey YPJUNDFVDDCYIH-UHFFFAOYSA-N
Smiles C(=O)(C(C(C(F)(F)F)(F)F)(F)F)O
Isomeric SMILES C(=O)(C(C(C(F)(F)F)(F)F)(F)F)O
WGK Germany 3
RTECS ET4025000
UN Number 3265
Packing Group I
Molecular Weight 214.04
Beilstein 1426882
Reaxy-Rn 1426882
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1426882&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

47 results found

Lot Number Certificate Type Date Item
C2503117 Certificate of Analysis Jun 11, 2025 H106257
C2503118 Certificate of Analysis Jun 11, 2025 H106257
C2503116 Certificate of Analysis Jun 11, 2025 H106257
A2510594 Certificate of Analysis Apr 08, 2025 H106257
A2510601 Certificate of Analysis Apr 08, 2025 H106257
A2510600 Certificate of Analysis Apr 08, 2025 H106257
C2404422 Certificate of Analysis Apr 02, 2025 H106257
C2404427 Certificate of Analysis Apr 02, 2025 H106257
C2404418 Certificate of Analysis Apr 02, 2025 H106257
K2429491 Certificate of Analysis Mar 04, 2025 H106257
K2429493 Certificate of Analysis Mar 04, 2025 H106257
A2510599 Certificate of Analysis Dec 27, 2024 H106257
K2429492 Certificate of Analysis Nov 08, 2024 H106257
K2429494 Certificate of Analysis Nov 08, 2024 H106257
H2405242 Certificate of Analysis Nov 07, 2024 H106257
H2405240 Certificate of Analysis Nov 07, 2024 H106257
H2405241 Certificate of Analysis Nov 07, 2024 H106257
J2412347 Certificate of Analysis Oct 24, 2024 H106257
J2412445 Certificate of Analysis Oct 24, 2024 H106257
J2412446 Certificate of Analysis Oct 24, 2024 H106257
D2429268 Certificate of Analysis Aug 07, 2024 H106257
D2429269 Certificate of Analysis Aug 07, 2024 H106257
D2429270 Certificate of Analysis Aug 07, 2024 H106257
H2405239 Certificate of Analysis Jul 23, 2024 H106257
C2404430 Certificate of Analysis Jun 17, 2024 H106257
C2404423 Certificate of Analysis Jun 17, 2024 H106257
C2404431 Certificate of Analysis Jun 17, 2024 H106257
C2404424 Certificate of Analysis Feb 21, 2024 H106257
I2314302 Certificate of Analysis Dec 14, 2023 H106257
I2314301 Certificate of Analysis Dec 14, 2023 H106257
I2314300 Certificate of Analysis Dec 14, 2023 H106257
I2314299 Certificate of Analysis Dec 14, 2023 H106257
H2318083 Certificate of Analysis Nov 20, 2023 H106257
L2322027 Certificate of Analysis Nov 08, 2023 H106257
L2121589 Certificate of Analysis Nov 08, 2023 H106257
I2224399 Certificate of Analysis Oct 18, 2023 H106257
I2224405 Certificate of Analysis Oct 18, 2023 H106257
G2313207 Certificate of Analysis May 11, 2023 H106257
C2218293 Certificate of Analysis Jan 16, 2023 H106257
C2218299 Certificate of Analysis Jan 16, 2023 H106257
C2218276 Certificate of Analysis Jan 16, 2023 H106257
C2218300 Certificate of Analysis Jan 16, 2023 H106257
I2224406 Certificate of Analysis Jan 12, 2023 H106257
I2224404 Certificate of Analysis Jan 12, 2023 H106257
L2121585 Certificate of Analysis Nov 15, 2022 H106257
L2121602 Certificate of Analysis Nov 15, 2022 H106257
I2109367 Certificate of Analysis Jan 11, 2022 H106257

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Chemical and Physical Properties

Solubility Soluble in water, toluene, ether, ethanol (0.1 ml/ml), and benzene.
Sensitivity Light & Moisture Sensitive
Refractive Index 1.3
Boil Point(°C) 120°C
Melt Point(°C) -20°C(lit.)
Molecular Weight 214.040 g/mol
XLogP3 2.200
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 9
Rotatable Bond Count 2
Exact Mass 213.986 Da
Monoisotopic Mass 213.986 Da
Topological Polar Surface Area 37.300 Ų
Heavy Atom Count 13
Formal Charge 0
Complexity 217.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

Citations of This Product

1. Fan Dong, Fan Ge, Xinting Zhao, Daming Sun, Suyu Ren, Yan Wang, Feng Tan.  (2024)  Measurement of perfluoroalkyl substances in drinking water sources by DGT sampler with a novel fluorinated graphite binding gel.  SCIENCE OF THE TOTAL ENVIRONMENT,  912  (169658). 
2. Zhuoran Feng, Hangjia Zhao, Xiaoyue Ji, Xiangni Lu, Xueyan Li, Ying Zhao, Wei Wang, Jun Ma, Zhiqiang Sun.  (2023)  Comprehensively Evaluating the Effect of Ionic Strength on Interaction Behaviors Between PFASs and Carbon Nanoparticles in an Aquatic Environment.  ACS ES&T Water,     
3. Lingyue Zhang, Chu Tang, Dongbei Yue.  (2024)  Insights into the adsorption of perfluoroalkyl substances (PFASs) on excess sludge from an on-site leachate treatment plant.  SEPARATION AND PURIFICATION TECHNOLOGY,  331  (125639). 
4. Wei Zhang, Qing Long, Guifeng Li, Zigong Ning, Lu Lu.  (2023)  Electrochemical oxidation coupled with hydrated electron reduction in ultraviolet (UV)-sulfite system for complete defluorination and mineralization of Perfluorooctanoic Acid (PFOA).  Journal of Water Process Engineering,  53  (103836). 
5. Xi Tan, Yan Shi, Chun-Feng Ma, Quan Chi, Yu-Hang Yang, Wen-Xiang Zhang, Hua-Ming Xiao, Xian Wang.  (2024)  Fluoro-functionalized plant biomass adsorbent: Preparation and application in extraction of trace perfluorinated compounds from environmental water samples.  Journal of Environmental Sciences,  137  (703). 
6. Xianjun Tan, Zhenying Jiang, Wenhui Ding, Mingkun Zhang, Yuxiong Huang.  (2023)  Multiple interactions steered high affinity toward PFAS on ultrathin layered rare-earth hydroxide nanosheets: Remediation performance and molecular-level insights.  WATER RESEARCH,  230  (119558). 
7. Mingkun Zhang, Xianjun Tan, Wenhui Ding, Zhenying Jiang, Kai He, Bo Zhao, Haruka Takeuchi, Yuxiong Huang.  (2023)  Aluminum-based electrocoagulation for residual fluoride removal during per- and polyfluoroalkyl substances (PFASs) wastewater treatment.  SEPARATION AND PURIFICATION TECHNOLOGY,  308  (122989). 
8. Xiaoyi Chen, Sameer Hussain, Yuhai Tang, Xi Chen, Sijie Zhang, Yue Wang, Pei Zhang, Ruixia Gao, Sicen Wang, Yi Hao.  (2023)  Two-in-one platform based on conjugated polymer for ultrasensitive ratiometric detection and efficient removal of perfluoroalkyl substances from environmental water.  SCIENCE OF THE TOTAL ENVIRONMENT,  860  (160467). 
9. Hong Yin, Ruya Chen, Haibo Wang, Cory Schwarz, Haotian Hu, Baoyou Shi, Yili Wang.  (2023)  Co-occurrence of phthalate esters and perfluoroalkyl substances affected bacterial community and pathogenic bacteria growth in rural drinking water distribution systems.  SCIENCE OF THE TOTAL ENVIRONMENT,  856  (158943). 
10. Li Xu, Xiaona Yang, Xue Fu, Li Wang, Yong Fan, Jianing Xu, Yanzhen Yin, Limei Tian, Jie Zhao.  (2022)  Fluorinated epoxy based superhydrophobic coating with robust self-healing and anticorrosive performances.  PROGRESS IN ORGANIC COATINGS,  171  (107045). 
11. Min Yang, Xiaolei Zhang, Yicheng Yang, Qiang Liu, Long D. Nghiem, Wenshan Guo, Huu Hao Ngo.  (2022)  Effective destruction of perfluorooctanoic acid by zero-valent iron laden biochar obtained from carbothermal reduction: Experimental and simulation study.  SCIENCE OF THE TOTAL ENVIRONMENT,  805  (150326). 
12. Wenhui Ding, Xianjun Tan, Guanhan Chen, Jingyi Xu, Kuang Yu, Yuxiong Huang.  (2021)  Molecular-Level Insights on the Facet-Dependent Degradation of Perfluorooctanoic Acid.  ACS Applied Materials & Interfaces,  13  (35): (41584–41592). 
13. Jiaxin Zhu, Yihua Chen, Yurong Gu, Hang Ma, Mingyue Hu, Xinlei Gao, Tongzhou Liu.  (2022)  Feasibility study on the electrochemical reductive decomposition of PFOA by a Rh/Ni cathode.  JOURNAL OF HAZARDOUS MATERIALS,  422  (126953). 
14. Yongquan Qing, Songlin Shi, Cunjing Lv, Quanshui Zheng.  (2020)  Microskeleton-Nanofiller Composite with Mechanical Super-Robust Superhydrophobicity against Abrasion and Impact.  ADVANCED FUNCTIONAL MATERIALS,  30  (39): (1910665). 
15. Mu Li, Feiyun Sun, Wentao Shang, Xiaolei Zhang, Wenyi Dong, Tongzhou Liu, Wen Pang.  (2019)  Theoretical studies of perfluorochemicals (PFCs) adsorption mechanism on the carbonaceous surface.  CHEMOSPHERE,  235  (606). 
16. Mengyu Li, Ning Liu, Qiaoling Li.  (2019)  A novel core-shell epoxy high performance composite: Self-lubricating, heat-resistant and self-repairing.  PROGRESS IN ORGANIC COATINGS,  129  (217). 
17. Yurong Gu, Tongzhou Liu, Qian Zhang, Wenyi Dong.  (2017)  Efficient decomposition of perfluorooctanoic acid by a high photon flux UV/sulfite process: Kinetics and associated toxicity.  CHEMICAL ENGINEERING JOURNAL,  326  (1125). 
18. Zhiquan An, Xiaoyu Jian, Wenjun Hong, Xilong Zhang, Jiateng Ma, Minjie Li, Bihong Zhang, Liang-Hong Guo.  (2025)  An ultrasensitive free-of-electronic sacrificial agent photoelectrochemical aptasensor for the detection of dibutyl phthalate based on Z-scheme p-n Bi-doped BiOI/Bi2S3 heterojunction.  TALANTA,  282  (126997). 
19. Xin Huang, Junhao Huang, Kaiyun Wang, Mingming Hao, Mengze Geng, Baoyou Shi, Chengzhi Hu.  (2024)  Comparison of perfluoroalkyl substance adsorption performance by inorganic and organic silicon modified activated carbon.  WATER RESEARCH,  260  (121919). 
20. Luyue Zhao, Shu Li, Tong Wang, Sinan Wang, Jinhua Zhan, Jing Chen.  (2025)  Cost-effective magnetic Nylon 6 composites for extraction of perfluorinated compounds in water and bottled beverage followed with LC-MS/MS analysis.  FOOD CHEMISTRY,    (143944). 
21. Liang Fang, Li Zhu, Wang Zinan, Ke Xin, Wu Longhua, Christie Peter, Luo Yongming.  (2024)  Effects of per- and polyfluoroalkyl substances (PFASs) on hatching of Folsomia candida (Collembola) on soil.  Soil Ecology Letters,  (4): (1-8). 
22. Junjie Li, Liang Li, Jing Zhang, Chun Yang, Jun Ma.  (2024)  Efficient defluorination of PFOA by vacuum ultraviolet coupling with sulfite and iodide.  Journal of Water Process Engineering,  66  (106079). 
23. Yihua Chen, Jiaxin Zhu, Hang Ma, Yurong Gu, Tongzhou Liu.  (2024)  Fe2+-NTA synergized UV254 photolytic defluorination of perfluorooctane sulfonate (PFOS): Enhancing through intramolecular electron density perturbation via electron acquisition.  WATER RESEARCH,  254  (121421). 
24. Zeliang Liu, Xuanlin Cao, Manli Wu, Wenjie Huang, Xia Dong, Xing Chen, Chun Zhang.  (2025)  Mechanisms of PFBA toxicity in Chlorella vulgaris: Photosynthesis, oxidative stress, and antioxidant impairment.  ENVIRONMENTAL RESEARCH,  273  (121228). 
25. Ting Liu, Chunfeng Ma, Zheng Hu, Yinghong Huang, Xian Wang.  (2024)  Novel pillar[n]arenes magnetic nanoparticles: Preparation and application in quantitative analysis of trace perfluorinated compounds from aqueous samples.  ANALYTICA CHIMICA ACTA,    (343067). 
26. Yue Li, Xiaoying Zheng, Zhilin Zhao, Wenfei Li, Yu Huang, Haidong He, Zongshuo Han, Jiaqing Tao, Tao Lin.  (2024)  Perfluorobutanoic acid weakens the heterogeneous aggregation of microplastics and microalgae: Perspective from physicochemical properties, extracellular polymeric substances secretion and DLVO theory.  SCIENCE OF THE TOTAL ENVIRONMENT,  955  (177127). 
27. Xiaoyuan Wang, Yinchuan Lv, Xin Qiang, Shumin Liang, Ruosi Li, Jing Zhan, Jiaying Liu.  (2024)  Perfluorooctanoic acid (PFOA) and its alternative perfluorobutanoic acid (PFBA) alter hepatic bile acid profiles via different pathways.  SCIENCE OF THE TOTAL ENVIRONMENT,  950  (175312). 
28. Zhilin Zhao, Xiaoying Zheng, Yue Li, Zongshuo Han, Yu Tang, Tianxing Hu, Tao Lin.  (2025)  Polystyrene microplastics attenuated the impact of perfluorobutanoic acid on Chlorella sorokiniana: Hetero-aggregation, bioavailability, physiology, and transcriptomics.  JOURNAL OF HAZARDOUS MATERIALS,  488  (137344). 
29. Xiaonan Xu, Nana Luo, Wan-Hui Wang, Ming Bao, Jiasheng Wang.  (2024)  Revealing the Effects of Mo Doping to Ni on Catalyzing Hydrogenation of Fatty Acids to Fatty Alcohols.  ACS Applied Materials & Interfaces,  16  (51): (70489-70497). 
30. Yang Zhang, Yucui Xu, Baoyou Shi, Xin Huang.  (2024)  The influence of nitrogen-containing functional groups and pore structure on the adsorption of per- and polyfluoroalkyl substances in ultrapure and real water.  Journal of Environmental Chemical Engineering,  12  (112082). 
31. Jiaoxia Sun, Xueting Jiang, Hong Xiang, Xi Wang, Xue Luo, Jiang Fu, Jianxin Fan.  (2024)  TPU/PEI nanofibers for the efficient removal of PFOA and its analogs: Effect of pH, humic acid and co-existing ions, mechanism, and regenerative effects.  Journal of Environmental Chemical Engineering,  12  (113210). 

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