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Heptafluorobutyric anhydride - for GC derivatization, ≥99.0%, high purity , CAS No.336-59-4

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Heptafluorobutyric anhydride - for GC derivatization, ≥99.0%, high purity , CAS No.336-59-4

9 Citations

COA

Grade & Purity:

for GC derivatization

≥99%

Cas Number: 336-59-4
Molecular Weight: 410.06
Beilstein Registry Number: 856036
EC Number: 206-410-8
MDL number: MFCD00000432
PubChem CID: 67643

In stock

Item Number

H122092

Grouped product items
SKU	Size	Availability	Price
H122092-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$68.90
H122092-5ml	5ml	3	$262.90
H122092-10×1ml	10×1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$620.90
H122092-25ml	25ml	3	$1,028.90

Basic Description

Synonyms	BCP22497 \| Heptafluorobutyric anhydride \| HEPTAFLUOROBUTYRYL ANHYDRIDE \| Heptafluorobutanoic anhydride \| J-521428 \| Butanoic acid, 2,2,3,3,4,4,4-heptafluoro-, 1,1'-anhydride \| GC10217 \| 1,1,2,2,3,3,3-Heptafluorobutanoic anhydride # \| DTXSID10861881 \| UNII
Specifications & Purity	for GC derivatization, ≥99%
Storage Temp	Argon charged
Shipped In	Normal
Grade	for GC derivatization
Product Description	Heptafluorobutyric anhydride (HFB) is a derivatizing reagent. It provides facile and sensitive way for detecting and elucidating structure of numerous alkyl-chain homologs.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organohalogen compounds
  - Class Alkyl halides
    - Subclass Alkyl fluorides

Kingdom	Organic compounds
Superclass	Organohalogen compounds
Class	Alkyl halides
Subclass	Alkyl fluorides
Intermediate Tree Nodes	Not available
Direct Parent	Perfluoroalkyl carboxylic acid and derivatives
Alternative Parents	Dicarboxylic acids and derivatives Carboxylic acid anhydrides Alpha-halocarboxylic acid derivatives Organofluorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic acyclic compounds
Substituents	Perfluoroalkyl carboxylic acid or derivatives - Dicarboxylic acid or derivatives - Carboxylic acid anhydride - Alpha-halocarboxylic acid or derivatives - Alpha-halocarboxylic acid derivative - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organofluoride - Carbonyl group - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as perfluoroalkyl carboxylic acid and derivatives. These are organic compounds containing an alkyl chain attached to the C-alpha of a carboxylic acid group (or a derivative thereof), where all hydrogens of the alkyl chain are replaced by fluorine atoms.
External Descriptors	organofluorine compound - acyclic carboxylic anhydride
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	2,2,3,3,4,4,4-heptafluorobutanoyl 2,2,3,3,4,4,4-heptafluorobutanoate
INCHI	InChI=1S/C8F14O3/c9-3(10,5(13,14)7(17,18)19)1(23)25-2(24)4(11,12)6(15,16)8(20,21)22
InChIKey	UFFSXJKVKBQEHC-UHFFFAOYSA-N
Smiles	C(=O)(C(C(C(F)(F)F)(F)F)(F)F)OC(=O)C(C(C(F)(F)F)(F)F)(F)F
Isomeric SMILES	C(=O)(C(C(C(F)(F)F)(F)F)(F)F)OC(=O)C(C(C(F)(F)F)(F)F)(F)F
WGK Germany	3
Molecular Weight	410.06
Beilstein	856036
Reaxy-Rn	856036
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=856036&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

17 results found

Lot Number	Certificate Type	Date	Item
A2419406	Certificate of Analysis	Jun 17, 2025	H122092
D2503427	Certificate of Analysis	Apr 12, 2025	H122092
D2503428	Certificate of Analysis	Apr 12, 2025	H122092
D2503444	Certificate of Analysis	Apr 12, 2025	H122092
L2410083	Certificate of Analysis	Dec 14, 2024	H122092
J2421272	Certificate of Analysis	Aug 06, 2024	H122092
A2419402	Certificate of Analysis	Jan 25, 2024	H122092
A2419403	Certificate of Analysis	Jan 25, 2024	H122092
A2419404	Certificate of Analysis	Jan 25, 2024	H122092
A2419405	Certificate of Analysis	Jan 25, 2024	H122092
A2419407	Certificate of Analysis	Jan 25, 2024	H122092
L2301251	Certificate of Analysis	Dec 11, 2023	H122092
I2306550	Certificate of Analysis	Sep 11, 2023	H122092
I2306497	Certificate of Analysis	Sep 11, 2023	H122092
K2215697	Certificate of Analysis	Aug 03, 2023	H122092
K2215696	Certificate of Analysis	Aug 03, 2023	H122092
K2215693	Certificate of Analysis	Aug 03, 2023	H122092

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Chemical and Physical Properties

Solubility	Miscible with halogenated solvents. Immiscible with polar solvents.
Sensitivity	Humidity Sensitive
Refractive Index	1.287
Boil Point(°C)	108-111°C
Melt Point(°C)	-43°C
Molecular Weight	410.060 g/mol
XLogP3	4.800
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	6
Exact Mass	409.962 Da
Monoisotopic Mass	409.962 Da
Topological Polar Surface Area	43.400 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	493.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Suleixin Yang, Yi Wu, Wenzhao Zhong, Ruie Chen, Meilin Wang, Meiwan Chen. (2023) GSH/Ph Dual Activatable Crosslinked And Fluorinated Pei for Cancer Gene Therapy Through Endogenous Iron De-Hijacking And in Situ Ros Amplification. ADVANCED MATERIALS, (2304098).
2. Shengnan Ma, Lei Song, Yueyue Bai, Shihao Wang, Jiao Wang, Haohao Zhang, Fazhan Wang, Yiyan He, Chuntao Tian, Guijun Qin. (2023) Improved intracellular delivery of exosomes by surface modification with fluorinated peptide dendrimers for promoting angiogenesis and migration of HUVECs. RSC Advances, 13 (17): (11269-11277).
3. Peng Hua, Donglin Yang, Ruie Chen, Peiqi Qiu, Meiwan Chen. (2022) ROS responsive polyethylenimine-based fluorinated polymers for enhanced transfection efficiency and lower cytotoxicity. Bosnian Journal of Basic Medical Sciences, 22 (4): ( 593–607).
4. Suleixin Yang, Ka Hong Wong, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen. (2022) ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy. Acta Biomaterialia, 140 (492).
5. Fangyin Zhu, Liang Xu, Xudong Li, Ziying Li, Jun Wang, Haijun Chen, Xiumei Li, Yu Gao. (2021) Co-delivery of gefitinib and hematoporphyrin by aptamer-modified fluorinated dendrimer for hypoxia alleviation and enhanced synergistic chemo-photodynamic therapy of NSCLC. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 167 (106004).
6. Hongyuan Yuan, Yong Yang, Wei Xue, Zonghua Liu. (2019) Fluorinated Redox-Responsive Poly(amidoamine) as a Vaccine Delivery System for Antitumor Immunotherapy. ACS Biomaterials Science & Engineering, 5 (2): (644–653).
7. Ma Shengnan, Zhou Jie, Wali Aisha Roshan Mohamed, He Yiyan, Xu Xianghui, Tang James Zhenggui, Gu Zhongwei. (2015) Self-assembly of pH-sensitive fluorinated peptide dendron functionalized dextran nanoparticles for on-demand intracellular drug delivery. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 26 (8): (1-13).
8. Qiurong Deng,Xudong Li,Lipeng Zhu,Hua He,Donglai Chen,Yongbing Chen,Lichen Yin. (2017-05-18) Serum-resistant, reactive oxygen species (ROS)-potentiated gene delivery in cancer cells mediated by fluorinated, diselenide-crosslinked polyplexes.. Biomaterials science, 5 ((6)): (1174-1182).
9. Peng Hua, Ruifeng Liang, Suleixin Yang, Yanbei Tu, Meiwan Chen. (2024) Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis. Bioactive Materials, 36 (83).

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