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GW 627368 - ≥98%(HPLC), high purity , CAS No.439288-66-1, Antagonist of EP 4 receptor

Name: GW 627368 - ≥98%(HPLC), high purity , CAS No.439288-66-1, Antagonist of EP 4 receptor
Price: 15.9 USD
Availability: InStock

COA

Grade & Purity:

Moligand™

≥98%(HPLC)

Cas Number: 439288-66-1
Molecular Weight: 544.62
PubChem CID: 5312130
PubChem SID: 504763559

In stock

Item Number

G288949

Grouped product items
SKU	Size	Availability	Price
G288949-1mg	1mg	2	$15.90
G288949-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$64.90
G288949-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$97.90
G288949-25mg	25mg	2	$162.90
G288949-50mg	50mg	2	$271.90
G288949-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,224.90

Selective EP4receptor competitive antagonist

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Class A GPCR (4138) EP4 receptor Antagonist (18) GPCR/G Protein (3172) Prostaglandin Receptor (169)

Synonyms	A842355 \| NSC 96380 \| GW627368X \| GW-627368X \| BCP15277 \| EX-A603 \| GW 627368 \| SY029966 \| Benzeneacetamide, 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz(f)isoindol-2-yl)-N-(phenylsulfonyl)- \| DB08074 \| HMS3650M04 \| 2-(4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-be
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective prostanoid EP4receptor competitive antagonist with additional affinity at TP receptors (pKivalues are 7.0 and 6.8 in competition radioligand bioassays). Affinity for all other prostanoid receptors is < 5.3. Inhibits U-46619 induced human platel
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of EP 4 receptor

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Isoindoles and derivatives
Subclass	Isoindolines
Intermediate Tree Nodes	Not available
Direct Parent	Isoindolones
Alternative Parents	Phenylacetamides Benzenesulfonamides Naphthalenes Benzenesulfonyl compounds Isoindoles Phenol ethers Alkyl aryl ethers Tertiary carboxylic acid amides Aminosulfonyl compounds Organosulfonic acids and derivatives Lactams Azacyclic compounds Carbonyl compounds Organonitrogen compounds Hydrocarbon derivatives Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzenesulfonamide - Naphthalene - Phenylacetamide - Isoindolone - Benzenesulfonyl group - Isoindole - Phenol ether - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Aminosulfonyl compound - Tertiary carboxylic acid amide - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Lactam - Carboxamide group - Carboxylic acid derivative - Ether - Azacycle - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as isoindolones. These are aromatic polycyclic compounds that an isoindole bearing a ketone.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Pubchem Sid	504763559
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504763559
IUPAC Name	N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide
INCHI	InChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35,36)22-10-6-5-7-11-22/h5-17H,3-4,18-19H2,1-2H3,(H,31,33)
InChIKey	XREWXJVMYAXCJV-UHFFFAOYSA-N
Smiles	CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=CC=C(C=C4)CC(=O)NS(=O)(=O)C5=CC=CC=C5
Isomeric SMILES	CCOC1=C2CN(C(=O)C2=C(C3=CC=CC=C31)OCC)C4=CC=C(C=C4)CC(=O)NS(=O)(=O)C5=CC=CC=C5
Molecular Weight	544.62
Reaxy-Rn	10400252
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10400252&ln=

Lot Number	Certificate Type	Date	Item
L2412370	Certificate of Analysis	Dec 18, 2024	G288949
J2115201	Certificate of Analysis	Jul 15, 2024	G288949
J2115223	Certificate of Analysis	Jul 15, 2024	G288949
J2115247	Certificate of Analysis	Jul 15, 2024	G288949
J2115314	Certificate of Analysis	Jul 15, 2024	G288949
J2115348	Certificate of Analysis	Jul 15, 2024	G288949
J2115351	Certificate of Analysis	Jul 15, 2024	G288949

Solubility	Solvent:DMSO, Max Conc. mg/mL: 54.46, Max Conc. mM: 100
Molecular Weight	544.600 g/mol
XLogP3	4.800
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	544.167 Da
Monoisotopic Mass	544.167 Da
Topological Polar Surface Area	110.000 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	953.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

GW 627368 - ≥98%(HPLC), high purity , CAS No.439288-66-1, Antagonist of EP 4 receptor

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