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GeA-69 - 99%, high purity , CAS No.2143475-98-1

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GeA-69 - 99%, high purity , CAS No.2143475-98-1

COA

Grade & Purity:

≥99%

Cas Number: 2143475-98-1
Molecular Weight: 300.35
PubChem CID: 135397654

In stock

Item Number

G412515

Grouped product items
SKU	Size	Availability	Price
G412515-5mg	5mg	2	$73.90
G412515-25mg	25mg	2	$246.90
G412515-50mg	50mg	2	$414.90
G412515-100mg	100mg	2	$672.90
G412515-250mg	250mg	2	$1,514.90

PARP Inhibitors

View related series

Cell Cycle/DNA Damage (2602) DNA Damage (697) Epigenetics (1496) Histone Modification (1379) PARP (124)

Basic Description

Synonyms	N-[2-(9H-Carbazol-1-yl)phenyl]-acetamide
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	GeA-69 is a cell-permeable, selective allosteric inhibitor targeting macrodomain 2 (MD2) of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) with Kd of 860 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information GeA-69 GeA-69 is a cell-permeable, selective allosteric inhibitor targeting macrodomain 2 (MD2) of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) with Kd of 860 nM. Targets PARP14-MD2 (Cell-free assay) 860 nM(Kd)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass Carbazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	Carbazoles
Intermediate Tree Nodes	Not available
Direct Parent	Carbazoles
Alternative Parents	Acetanilides N-acetylarylamines Indoles Pyrroles Heteroaromatic compounds Acetamides Secondary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Carbazole - Acetanilide - N-acetylarylamine - Anilide - Indole - N-arylamide - Benzenoid - Monocyclic benzene moiety - Heteroaromatic compound - Acetamide - Pyrrole - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as carbazoles. These are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	3.962
hba_count	1
HBD Count	2
Rotatable Bond	2

Associated Targets(Human)

PARP14 Tchem Poly [ADP-ribose] polymerase 14 (2 Activities)

Discover Target: PARP14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-[2-(9H-carbazol-1-yl)phenyl]acetamide
INCHI	InChI=1S/C20H16N2O/c1-13(23)21-18-11-4-2-7-14(18)16-9-6-10-17-15-8-3-5-12-19(15)22-20(16)17/h2-12,22H,1H3,(H,21,23)
InChIKey	LDPDVNYCIOHPGF-UHFFFAOYSA-N
Smiles	CC(=O)NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C34
Isomeric SMILES	CC(=O)NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C34
Molecular Weight	300.35
Reaxy-Rn	32144804
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32144804&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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6 results found

Lot Number	Certificate Type	Date	Item
I2216047	Certificate of Analysis	Jun 16, 2025	G412515
I2216046	Certificate of Analysis	Jun 16, 2025	G412515
I2216045	Certificate of Analysis	Jun 16, 2025	G412515
I2216043	Certificate of Analysis	Jun 10, 2025	G412515
I2216044	Certificate of Analysis	Jun 10, 2025	G412515
C2524069	Certificate of Analysis	Jul 07, 2022	G412515

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 60 mg/mL (199.76 mM); Ethanol: 10 mg/mL (33.29 mM); Water: Insoluble;
Sensitivity	Moisture sensitive
DMSO(mg / mL) Max Solubility	60
DMSO(mM) Max Solubility	199.766938571666
Water(mg / mL) Max Solubility	＜1
Molecular Weight	300.400 g/mol
XLogP3	4.200
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	300.126 Da
Monoisotopic Mass	300.126 Da
Topological Polar Surface Area	44.900 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	437.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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