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FTI 277 - ≥95%(HPLC), high purity , CAS No.1217447-06-7

COA

Grade & Purity:

≥95%(HPLC)

Cas Number: 1217447-06-7
Molecular Weight: 561.64
PubChem CID: 71311821

In stock

Item Number

F287477

Grouped product items
SKU	Size	Availability	Price	Qty
F287477-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$140.90

Prodrug form ofFTI 276

View related series

Amino Acid/Protein Metabolism (1836) Apoptosis (4276) G Protein Related (287)

Basic Description

Synonyms	N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt
Specifications & Purity	≥95%(HPLC)
Biochemical and Physiological Mechanisms	Prodrug form ofFTI 276 that inhibits farnesyltransferase (FTase) (IC50= 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50values are 0.1 and 10μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Methionine and derivatives

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent	Methionine and derivatives
Alternative Parents	Alpha amino acid esters Hippuric acids and derivatives N-acyl-alpha amino acids and derivatives Biphenyls and derivatives Aminobenzamides Aniline and substituted anilines Benzoyl derivatives Phenylalkylamines Fatty acid esters Secondary alkylarylamines Methyl esters Alpha-halocarboxylic acids Secondary carboxylic acid amides Sulfenyl compounds Dialkylthioethers Carboxylic acids Alkylthiols Monocarboxylic acids and derivatives Monoalkylamines Hydrocarbon derivatives Carbonyl compounds Alkyl fluorides Organofluorides Organic oxides
Molecular Framework	Not available
Substituents	Methionine or derivatives - Alpha-amino acid ester - Hippuric acid or derivatives - N-acyl-alpha amino acid or derivatives - Biphenyl - Aminobenzamide - Aminobenzoic acid or derivatives - Benzamide - Benzoic acid or derivatives - Phenylalkylamine - Aniline or substituted anilines - Benzoyl - Fatty acid ester - Secondary aliphatic/aromatic amine - Monocyclic benzene moiety - Fatty acyl - Benzenoid - Alpha-halocarboxylic acid - Alpha-halocarboxylic acid or derivatives - Methyl ester - Secondary carboxylic acid amide - Carboxylic acid ester - Carboxamide group - Secondary amine - Dialkylthioether - Thioether - Monocarboxylic acid or derivatives - Alkylthiol - Sulfenyl compound - Carboxylic acid - Organosulfur compound - Carbonyl group - Primary aliphatic amine - Organohalogen compound - Alkyl halide - Alkyl fluoride - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Amine - Organofluoride - Organonitrogen compound - Organic nitrogen compound - Primary amine - Organooxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as methionine and derivatives. These are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate;2,2,2-trifluoroacetic acid
INCHI	InChI=1S/C22H29N3O3S2.C2HF3O2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);(H,6,7)/t16-,20+;/m1./s1
InChIKey	GJEFFRDWFVSCOJ-PXPMWPIZSA-N
Smiles	COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
Isomeric SMILES	COC(=O)[C@H](CCSC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
PubChem CID	71311821
Molecular Weight	561.64

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 2.81, Max Conc. mM: 5
Molecular Weight	561.600 g/mol
XLogP3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	12
Exact Mass	561.158 Da
Monoisotopic Mass	561.158 Da
Topological Polar Surface Area	157.000 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	615.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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