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Flavopiridol HCl - ≥99%, high purity , CAS No.131740-09-5

COA

Grade & Purity:

≥99%

Cas Number: 131740-09-5
Molecular Weight: 438.3
PubChem CID: 9910986
PubChem SID: 504765078

In stock

Item Number

F129964

Grouped product items
SKU	Size	Availability	Price
F129964-5mg	5mg	3	$53.90
F129964-10mg	10mg	3	$86.90
F129964-25mg	25mg	3	$195.90
F129964-50mg	50mg	2	$206.90
F129964-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$360.90

Potent CDK and CDC25 phosphatase inhibitor

View related series

Anti-infection (2803) Autophagy (1917) CDK (252) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) HIV (254) Virus (1811)

Basic Description

Synonyms	4H-1-BENZOPYRAN-4-ONE, 2-(2-CHLOROPHENYL)-5,7-DIHYDROXY-8-((3S,4R)-3-HYDROXY-1-METHYL-4-PIPERIDINYL)-, HYDROCHLORIDE (1:1) \| BCP9000688 \| rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochlo
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Flavopiridol hydrochloride is a pan-cdk inhibitor.Potent ATP-competitive CDK and CDC25 phosphatase inhibitor (IC 50 values are 40, 40, 40, 40 and 300 nM for CDK1,2,4,6 and 7 respectively). Inhibits EGFR and PKA (IC 50 values are 21 and 122 μM respectively
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product Describtion: Alvocidib Hydrochloride is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Flavonoids
    - Subclass Flavones

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Flavonoids
Subclass	Flavones
Intermediate Tree Nodes	Not available
Direct Parent	Flavones
Alternative Parents	5-hydroxyflavonoids 7-hydroxyflavonoids Phenylpiperidines Chromones Pyranones and derivatives 1-hydroxy-2-unsubstituted benzenoids Aralkylamines Chlorobenzenes Aryl chlorides Vinylogous acids Heteroaromatic compounds Trialkylamines Secondary alcohols 1,2-aminoalcohols Oxacyclic compounds Azacyclic compounds Hydrochlorides Organic oxides Organochlorides Hydrocarbon derivatives Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	5-hydroxyflavonoid - 7-hydroxyflavonoid - Flavone - Hydroxyflavonoid - Phenylpiperidine - Chromone - Benzopyran - 1-benzopyran - 1-hydroxy-2-unsubstituted benzenoid - Chlorobenzene - Halobenzene - Pyranone - Aralkylamine - Benzenoid - Pyran - Piperidine - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Heteroaromatic compound - Vinylogous acid - Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - 1,2-aminoalcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Alcohol - Organic oxide - Organopnictogen compound - Organic nitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Amine - Hydrochloride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as flavones. These are flavonoids with a structure based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

Caco-2 (12174 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504765078
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504765078
IUPAC Name	2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one;hydrochloride
INCHI	InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1
InChIKey	LGMSNQNWOCSPIK-LWHGMNCYSA-N
Smiles	CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
Isomeric SMILES	CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
Molecular Weight	438.3
Reaxy-Rn	25500302
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25500302&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
B2318070	Certificate of Analysis	Dec 05, 2024	F129964
B2318062	Certificate of Analysis	Dec 05, 2024	F129964
B2318083	Certificate of Analysis	Dec 05, 2024	F129964
B2318057	Certificate of Analysis	Dec 05, 2024	F129964
B23171122	Certificate of Analysis	Jan 14, 2023	F129964

Chemical and Physical Properties

Solubility	DMSO 88 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Sensitivity	Moisture sensitive
Molecular Weight	438.300 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	437.08 Da
Monoisotopic Mass	437.08 Da
Topological Polar Surface Area	90.200 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	628.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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