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Filipin complex - ≥97.0%, high purity , CAS No.11078-21-0

3 Citations COA COA
In stock
Item Number
F650764
Grouped product items
SKU Size
Availability
 Price Qty
F650764-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
F650764-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$105.90
F650764-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$379.90
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Antibiotics Disease Research Antifungal Antibiotics Disease Research Antiviral Antibiotics Other Antibiotics

View related series
Anti-infection (2803) Antibiotic (1629) Antibiotics Disease Research Antifungal Antibiotics Disease Research Antiviral Antibiotics Other Antibiotics (2) Fungal (844)

Basic Description

Synonyms 1',26-dihydroxyfilipin | U-5956 | Filimarisin | TK-336 | NSC3364 | NSC-3364 | 14-Deoxylagosin | FILIPIN DERIVATIVE | 1'-epi-filipin iv | GUDVQJXODNJRIJ-CALCHBBNSA-N | 4,6,8,10,12,14,16,27-Octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-oxacyclooctacosa-17,1
Specifications & Purity Moligand™, ≥97%(mixture)
Biochemical and Physiological Mechanisms Filipin 复合物是一种强效的多烯类大环内酯抗真菌抗生素。Filipin 复合物可插入膜中，将胆固醇螯合成复合物，抑制 PRRSV 的进入。Filipin 复合物由 70% 的 filipin III（HY-N6718）和 5% 的其他 filipin 同源物组成。
Storage Temp Protected from light,Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Product Description

A complex of polyene (pentaene) macrocyclic lactones antibiotics obtained from Streptomyces filipinensis. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.inhibits mitochondrial respiration.Filipin III is the most abundant component of the bulk complex (>>70%) of the complex.

In Vitro

Filipin complex (2 μg/ml; 1+48 h) inhibits PRRSV entry with respiratory syndrome virus (PRRSV) genome copies in infected cells reduced by 61% in MARC-145 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Macrolide

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Macrolides and analogues
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Macrolides and analogues
Alternative Parents Fatty alcohols  Secondary alcohols  Lactones  Carboxylic acid esters  Polyols  Oxacyclic compounds  Monocarboxylic acids and derivatives  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic heteromonocyclic compounds
Substituents Macrolide - Fatty alcohol - Fatty acyl - Carboxylic acid ester - Lactone - Secondary alcohol - Polyol - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organoheterocyclic compound - Oxacycle - Carbonyl group - Organooxygen compound - Organic oxide - Organic oxygen compound - Alcohol - Hydrocarbon derivative - Aliphatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.
External Descriptors olefinic compound - macrolide - polyol

Associated Targets(Human)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus cereus (7522 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Penicillium digitatum (260 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Colletotrichum (56 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Botrytis (43 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
INCHI InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
InChIKey IMQSIXYSKPIGPD-YQRUMEKGSA-N
Smiles CCCCCC(C1C(CC(CC(CC(CC(CC(CC(C(=CC=CC=CC=CC=CC(C(OC1=O)C)O)C)O)O)O)O)O)O)O)O
Isomeric SMILES CCCCC[C@H]([C@@H]1[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@@H](/C(=C/C=C/C=C/C=C/C=C/[C@@H]([C@H](OC1=O)C)O)/C)O)O)O)O)O)O)O)O
Alternate CAS 11078-21-0,480-49-9
MeSH Entry Terms Desoxylagosin;Filimarisin;Filipin;Filipin I;Filipin II;Filipin III;Filipin IV;NSC 3364;NSC-3364;NSC3364;U 5956;U-5956;U5956
Molecular Weight 654.80
Reaxy-Rn 1339814
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1339814&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number Certificate Type Date Item
B2510514 Certificate of Analysis Dec 30, 2024 F650764
B2510516 Certificate of Analysis Dec 30, 2024 F650764
B2510525 Certificate of Analysis Dec 30, 2024 F650764
B2510512 Certificate of Analysis Dec 30, 2024 F650764
B2510513 Certificate of Analysis Dec 30, 2024 F650764
B2510515 Certificate of Analysis Dec 30, 2024 F650764

Chemical and Physical Properties

Solubility DMSO : ≥ 100 mg/mL (152.72 mM) Ethanol : 10 mg/mL (15.27 mM; ultrasonic and warming and heat to 60°C)
Sensitivity Light sensitive
Molecular Weight 654.800 g/mol
XLogP3 3.200
Hydrogen Bond Donor Count 9
Hydrogen Bond Acceptor Count 11
Rotatable Bond Count 5
Exact Mass 654.398 Da
Monoisotopic Mass 654.398 Da
Topological Polar Surface Area 208.000 Ų
Heavy Atom Count 46
Formal Charge 0
Complexity 991.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 11
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 5
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 5
Covalently-Bonded Unit Count 1

Solution Calculators

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