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What types of targets are there?
posted this at 9 juin 2025 Updated at 17 nov. 2024
2
What types of targets are there?
| target_type |
target_desc |
parent type |
ADMET
|
Target is not applicable for an ADMET assay (e.g., physchem property) |
UNDEFINED |
| CELL-LINE |
Target is a specific cell-line |
NON-MOLECULAR |
| CHIMERIC PROTEIN |
Target is a fusion of two different proteins, either a synthetic construct or naturally occurring fusion protein |
PROTEIN |
| LIPID |
Target is a lipid |
MOLECULAR |
| MACROMOLECULE |
Target is a biological macromolecule (e.g., glycoproteins, hemozoin, hydroxyapatite) |
MOLECULAR |
| METAL |
Target is a metal e.g., iron |
MOLECULAR |
| MOLECULAR |
Target has been identified as a defined molecular entity (e.g., protein or nucleic acid) |
|
| NO TARGET |
Target is not applicable for a screening assay (e.g., negative control/counterscreen) |
UNDEFINED |
| NON-MOLECULAR |
Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc) |
|
| NUCLEIC-ACID |
Target is DNA, RNA or PNA |
MOLECULAR |
| OLIGOSACCHARIDE |
Target is an oligosaccharide (e.g., heparin, starch) |
MOLECULAR |
| ORGANISM |
Target is a complete organism |
NON-MOLECULAR |
| PHENOTYPE |
Target is a biological phenotype or process |
NON-MOLECULAR |
| PROTEIN |
Target is a protein or group of proteins |
MOLECULAR |
| PROTEIN COMPLEX |
Target is a defined protein complex, consisting of multiple subunits |
PROTEIN |
| PROTEIN COMPLEX GROUP |
Target is a poorly defined protein complex, where subunit composition is unclear (e.g., GABA-A receptor) |
PROTEIN |
| PROTEIN FAMILY |
Target is a group of closely related proteins |
PROTEIN |
| PROTEIN NUCLEIC-ACID COMPLEX |
Target is a complex consisting of both protein and nucleic-acid components (e.g., ribosome) |
MOLECULAR |
| PROTEIN-PROTEIN INTERACTION |
Target is the disruption of a protein-protein interaction |
PROTEIN |
| SELECTIVITY GROUP |
Target is a pair of proteins for which the selectivity has been assessed |
PROTEIN |
| SINGLE PROTEIN |
Target is a single protein chain |
PROTEIN |
| SMALL MOLECULE |
Target is a small molecule such as an amino acid, sugar or metabolite) |
MOLECULAR |
| SUBCELLULAR |
Target is a subcellular fraction |
NON-MOLECULAR |
| TISSUE |
Target is a healthy or diseased tissue |
NON-MOLECULAR |
| UNCHECKED |
Target has not yet been assigned |
UNDEFINED |
| UNDEFINED |
No target has been defined |
|
| UNKNOWN |
Molecular identity of target is unknown (e.g., pharmacologically defined target) |
UNDEFINED | |
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