What are the advantages of Friedel Crafts acylation?
What are the advantages of Friedel Crafts acylation?
posted this at Jun 9, 2025 Updated at Oct 9, 2023
What are the advantages of Friedel Crafts acylation?
Compared to Friedel-Crafts alkylation, Friedel-Crafts acylation has several advantages: better control of the reaction products, while the acyl ions have a positive charge on the carbon, and are resonance stable, so there is no chance of rearrangement. Using Clemens reduction, the ketones obtained can be reduced to alkyl groups.