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Etigilimab (anti-TIGIT) - Primary antibody, specific to TIGIT, Human IgG1, INHIBITOR of T-cell immunoreceptor with Ig and ITIM domains inhibitor, INHIBITOR of T-cell immunoreceptor with Ig and ITIM domains inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182857
Grouped product items
SKU Size
Availability
Price Qty
Ab182857-100μg
100μg
10
$89.90
Ab182857-1mg
1mg
4
$419.90
Ab182857-5mg
5mg
1
$1,259.90
Ab182857-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,019.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level < 0.01EU/μg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Etigilimab (anti-TIGIT) - Primary antibody, specific to TIGIT, Human IgG1, INHIBITOR of T-cell immunoreceptor with Ig and ITIM domains inhibitor
Synonyms DKFZp667A205 antibody | ENSMUSG00000071552 antibody | FLJ39873 antibody | RGD1563191 antibody | T cell immunoreceptor with Ig and ITIM domains antibody | TIGIT antibody | TIGIT_HUMAN antibody | V-set and immunoglobulin domain containing 9 antibody | V-set
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity TIGIT
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of T-cell immunoreceptor with Ig and ITIM domains inhibitor
Product Description

Etigilimab (anti-TIGIT), a humanized IgG1 monoclonal antibody, blocks TIGIT interaction with PVR (CD155; poliovirus receptor) and inhibits downstream signalling with target cell killing.
Purity>95% (SDS-PAGE&SEC)
Endotoxin Level < 0.01EU/μg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.6 kDa (Light Chain) & 51.1 kDa (Heavy Chain), under reducing conditions; 197.3 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2044984-83-8

Associated Targets(Human)

TIGIT Tbio T-cell immunoreceptor with Ig and ITIM domains (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Etigilimab (anti-TIGIT) (Ab182857) - ELISA
Immobilized Recombinant Human TIGIT protein (rp152378) at 1.0 μg/mL can bind Etigilimab (anti-TIGIT) (Ab182857) with the EC50 of 7.348 ng/mL.

Etigilimab (anti-TIGIT) (Ab182857) - SEC
The purity of Etigilimab (anti-TIGIT) (Ab182857) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0707802 Certificate of Analysis Jul 04, 2024 Ab182857
ZJ24F0707801 Certificate of Analysis Jul 04, 2024 Ab182857
ZJ24F0707800 Certificate of Analysis Jul 04, 2024 Ab182857

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