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Epristeride - 99%, high purity , CAS No.119169-78-7

COA

Grade & Purity:

≥99%

Cas Number: 119169-78-7
Molecular Weight: 399.57
PubChem CID: 68741

In stock

Item Number

E646215

Grouped product items
SKU	Size	Availability	Price
E646215-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$251.90
E646215-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$402.90
E646215-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$804.90

View related series

5 alpha Reductase (9) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	Ono-9302 \| 17-beta-N-t-Butylcarboxamide-androst-3,5-diene-3-carboxylic acid \| SK&F 105657 \| SKF 105657 \| BDBM50043604 \| Tox21_112993 \| VAPSMQAHNAZRKC-PQWRYPMOSA-N \| 39517A04PS \| EPRISTERIDE [MI] \| EPRISTERIDE [WHO-DD] \| D01134 \| Epristeride [USAN:INN:BAN]
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Epristeride (ONO-9302) is a selective, specific and orally active uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2 . Epristeride has inhibitory effects for SR isoenzymes types 2 with K i value of 0.7-2 nM. Epristeride can be used for t
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Epristeride (ONO-9302) is a selective, specific and orally active uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2 . Epristeride has inhibitory effects for SR isoenzymes types 2 with K i value of 0.7-2 nM. Epristeride can be used for the research of prostatic hyperplasia and acne In Vitro Epristeride has inhibitory effects for SR isoenzymes types 2 (SR2) with K i values of 0.7-2 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 0.7-2 nM(SR2)

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Steroids and steroid derivatives
    - Subclass Steroid acids

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Steroids and steroid derivatives
Subclass	Steroid acids
Intermediate Tree Nodes	Not available
Direct Parent	3-carboxy steroids
Alternative Parents	Androstane steroids Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic homopolycyclic compounds
Substituents	3-carboxy steroid - Androstane-skeleton - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Aliphatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as 3-carboxy steroids. These are steroid compounds that carry a carboxyl group at the C3-atom of the steroid backbone.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SRD5A1 Tclin 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (2 Activities)

Discover Target: SRD5A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SRD5A2 Tclin 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (10 Activities)

Discover Target: SRD5A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(8S,9S,10R,13S,14S,17S)-17-(tert-butylcarbamoyl)-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid
INCHI	InChI=1S/C25H37NO3/c1-23(2,3)26-21(27)20-9-8-18-17-7-6-16-14-15(22(28)29)10-12-24(16,4)19(17)11-13-25(18,20)5/h6,14,17-20H,7-13H2,1-5H3,(H,26,27)(H,28,29)/t17-,18-,19-,20+,24-,25-/m0/s1
InChIKey	VAPSMQAHNAZRKC-PQWRYPMOSA-N
Smiles	CC12CCC3C(C1CCC2C(=O)NC(C)(C)C)CC=C4C3(CCC(=C4)C(=O)O)C
Isomeric SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC(C)(C)C)CC=C4[C@@]3(CCC(=C4)C(=O)O)C
Alternate CAS	119169-78-7
PubChem CID	68741
MeSH Entry Terms	17-N-t-butylcarboxamide androst-3,5-diene-3-carboxylic acid;epristeride;ONO 9302;ONO-9302;SK and F 105657;SK and F-105657;SKF 105657
Molecular Weight	399.57

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (250.27 mM; Need ultrasonic)
Molecular Weight	399.600 g/mol
XLogP3	5.100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	399.277 Da
Monoisotopic Mass	399.277 Da
Topological Polar Surface Area	66.400 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	788.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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