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Epiberberine chloride - 99%, high purity , CAS No.889665-86-5

COA

Grade & Purity:

≥99%

Cas Number: 889665-86-5
Molecular Weight: 336.363545
PubChem CID: 71467079

In stock

Item Number

E650898

Grouped product items
SKU	Size	Availability	Price
E650898-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$90.90
E650898-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$120.90
E650898-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$440.90

Alkaloids Isoquinoline Alkaloids

View related series

Alkaloids Isoquinoline Alkaloids (17) Beta-secretase (28) Cholinesterase (ChE) (151) Glucose Metabolism (1943) Immunology/Inflammation (1929) Metabolic Enzyme/Protease (4860) Neuronal Signaling (3320) NF-κB (747) Reactive Oxygen Species (309)

Basic Description

Synonyms	UNII-ND559X5J59 \| Epiberberine chloride \| ND559X5J59 \| AKOS032944990 \| E80794 \| HY-N0226A \| 16,17-dimethoxy-5,7-dioxa-1-azoniapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaene;chloride \| MS-25997 \| Benzo(a)-1,3-benzodioxolo(4
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Epiberberine chloride is an alkaloid isolated from Coptis chinensis , acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC 50 s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, wi
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Epiberberine chloride is an alkaloid isolated from Coptis chinensis , acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC 50 s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO - scavenging effect (IC 50 , 16.83 μM), and may protect against Alzheimer disease Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways Epiberberine has the potential effect in the research of diabetic disease In Vitro Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC 50 of 52.8 μM. Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:AChE BACE1 BChE

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Alkaloids and derivatives
  - Class Protoberberine alkaloids and derivatives

Kingdom	Organic compounds
Superclass	Alkaloids and derivatives
Class	Protoberberine alkaloids and derivatives
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Protoberberine alkaloids and derivatives
Alternative Parents	Isoquinolines and derivatives Benzodioxoles Anisoles Alkyl aryl ethers Pyridinium derivatives Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Acetals Organopnictogen compounds Organonitrogen compounds Organic chloride salts Hydrocarbon derivatives Organic cations
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Protoberberine skeleton - Isoquinoline - Benzodioxole - Anisole - Alkyl aryl ether - Pyridine - Pyridinium - Benzenoid - Heteroaromatic compound - Acetal - Ether - Oxacycle - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic chloride salt - Organopnictogen compound - Organic salt - Organic cation - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	16,17-dimethoxy-5,7-dioxa-1-azoniapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaene;chloride
INCHI	InChI=1S/C20H18NO4.ClH/c1-22-18-8-13-5-6-21-10-15-12(3-4-17-20(15)25-11-24-17)7-16(21)14(13)9-19(18)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InChIKey	DGRBIBRPLDAHJH-UHFFFAOYSA-M
Smiles	COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC.[Cl-]
Isomeric SMILES	COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC.[Cl-]
PubChem CID	71467079
Molecular Weight	336.363545

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 25 mg/mL (67.24 mM; Need ultrasonic)
Molecular Weight	371.800 g/mol
XLogP3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	371.092 Da
Monoisotopic Mass	371.092 Da
Topological Polar Surface Area	40.800 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	488.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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