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EMD 386088 hydrochloride - ≥99%(HPLC), high purity , CAS No.1171123-46-8, Agonist of 5-HT 6 receptor

COA

Grade & Purity:

Moligand™

≥99%(HPLC)

Cas Number: 1171123-46-8
Molecular Weight: 283.20
PubChem CID: 56972198
PubChem SID: 504771521

In stock

Item Number

E288344

Grouped product items
SKU	Size	Availability	Price
E288344-5mg	5mg	3	$103.90
E288344-10mg	10mg	3	$118.90
E288344-25mg	25mg	2	$356.90
E288344-50mg	50mg	1	$479.90
E288344-100mg	100mg	1	$1,135.90

Potent 5-HT6agonist

View related series

5-HT6 receptor Agonist (27) Class A GPCR (4138)

Basic Description

Synonyms	HY-103130 \| WWB12346 \| 1171123-46-8 \| AKOS024457068 \| DTXSID90719336 \| EMD386088 \| EMD386088 hydrochloride \| EMD-386088 hydrochloride \| 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-Indole hydrochloride \| F6WU3NK3K8 \| 1H-Indole, 5-chloro-2-methy
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	Potent 5-HT6receptor agonist (EC50= 1.0 nM) that displays selectivity over other 5-HT receptors (IC50values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1Aand 5-HT7receptors respectively). Shows m
Storage Temp	Room temperature,Desiccated
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of 5-HT 6 receptor
Product Description	EMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 induced cell death. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential to study Alzheimer's disease (AD) and schizophrenia

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass Indoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	Indoles
Intermediate Tree Nodes	Not available
Direct Parent	Indoles
Alternative Parents	Substituted pyrroles Hydropyridines Benzenoids Aryl chlorides Heteroaromatic compounds Dialkylamines Azacyclic compounds Organochlorides Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Indole - Aryl chloride - Aryl halide - Hydropyridine - Benzenoid - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Secondary aliphatic amine - Azacycle - Secondary amine - Organohalogen compound - Hydrochloride - Amine - Hydrocarbon derivative - Organochloride - Organonitrogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HTR6 Tchem 5-hydroxytryptamine receptor 6 (1 Activities)

Discover Target: HTR6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	504771521
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771521
IUPAC Name	5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole;hydrochloride
INCHI	InChI=1S/C14H15ClN2.ClH/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9;/h2-4,8,16-17H,5-7H2,1H3;1H
InChIKey	WWSNDUWIZDYGIQ-UHFFFAOYSA-N
Smiles	CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3.Cl
Isomeric SMILES	CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3.Cl
WGK Germany	3
Molecular Weight	283.20
Reaxy-Rn	29671195
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29671195&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
A2420186	Certificate of Analysis	Dec 22, 2023	E288344
A2420188	Certificate of Analysis	Dec 22, 2023	E288344
A2420190	Certificate of Analysis	Dec 22, 2023	E288344
A2420192	Certificate of Analysis	Dec 22, 2023	E288344
A2420194	Certificate of Analysis	Dec 22, 2023	E288344
A2420187	Certificate of Analysis	Dec 22, 2023	E288344
A2420189	Certificate of Analysis	Dec 22, 2023	E288344
A2420191	Certificate of Analysis	Dec 22, 2023	E288344
A2420193	Certificate of Analysis	Dec 22, 2023	E288344
A2420195	Certificate of Analysis	Dec 22, 2023	E288344

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 7.08, Max Conc. mM: 25; Solvent:DMSO, Max Conc. mg/mL: 28.32, Max Conc. mM: 100
Molecular Weight	283.200 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	282.069 Da
Monoisotopic Mass	282.069 Da
Topological Polar Surface Area	27.800 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	315.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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