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E-64c - 98%, high purity , CAS No.76684-89-4

COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
E124386
Grouped product items
SKU Size
Availability
 Price Qty
E124386-1mg
1mg
8
$74.90
E124386-5mg
5mg
8
$157.90
E124386-10mg
10mg
6
$276.90
E124386-50mg
50mg
5
$989.90
E124386-100mg
100mg
4
$1,781.90
E124386-250mg
250mg
3
$4,009.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

E-64 ( ab141418 ) derivative. Irreversible cysteine protease inhibitor.

View related series
Amino Acid/Protein Metabolism (1836) Anti-infection (2803) Cathepsin (64) Metabolic Enzyme/Protease (4860) SARS-CoV (200) Virus (1811)

Basic Description

Synonyms Alcohol, Benzyl | e-64c | E-64-c | BRN 6688621 | SCHEMBL3281530 | CCG-207845 | HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | HY-100227 | DTXSID00859030 | cid_123664 | EX-A4095 | L-trans-Epoxysuccinyl-Leu-3-methylbutylamide | MFCD00132882 | (Carboxymethyl)trimethylammon
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Synthetic analog of E-64 , a potent, irreversible cysteine protease inhibitor isolated from Aspergillus japonicus . Effective calpain inhibitor, which also inhibits cathepsin B, cathepsin H, and cathepsin L. Inhibits calpain activity in intact
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Cysteine protease inhibitor; membrane-impermeable calpain inhibitor. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent Leucine and derivatives
Alternative Parents N-acyl-alpha amino acids and derivatives  Alpha amino acid amides  Oxirane carboxylic acids  N-acyl amines  Secondary carboxylic acid amides  Oxacyclic compounds  Monocarboxylic acids and derivatives  Dialkyl ethers  Carboxylic acids  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aliphatic heteromonocyclic compounds
Substituents Leucine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Fatty amide - N-acyl-amine - Oxirane carboxylic acid - Fatty acyl - Oxirane carboxylic acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid - Dialkyl ether - Oxirane - Ether - Monocarboxylic acid or derivatives - Oxacycle - Organoheterocyclic compound - Organopnictogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Carbonyl group - Aliphatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as leucine and derivatives. These are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors Not available

Associated Targets(Human)

CTSB Tchem Cathepsin B (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CAPN1 Tchem Calpain-1 catalytic subunit (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTSB Tchem Cathepsin B (3822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Papain (844 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cruzipain (33337 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CTSL Cathepsin L (58 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAPN1 Calpain 1 (219 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488187775
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488187775
IUPAC Name (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid
INCHI InChI=1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1
InChIKey SCMSYZJDIQPSDI-SRVKXCTJSA-N
Smiles CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1C(O1)C(=O)O
Isomeric SMILES CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1[C@H](O1)C(=O)O
WGK Germany 3
RTECS RR0404200
Molecular Weight 314.38
Reaxy-Rn 25759176
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25759176&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number Certificate Type Date Item
E23161295 Certificate of Analysis Mar 24, 2023 E124386
E23161275 Certificate of Analysis Mar 24, 2023 E124386
E23161265 Certificate of Analysis Mar 24, 2023 E124386
E23161274 Certificate of Analysis Mar 24, 2023 E124386
E23161282 Certificate of Analysis Mar 24, 2023 E124386
E23161267 Certificate of Analysis Mar 24, 2023 E124386
E23161281 Certificate of Analysis Mar 24, 2023 E124386
E23161268 Certificate of Analysis Mar 24, 2023 E124386
E23161277 Certificate of Analysis Mar 24, 2023 E124386
E23161276 Certificate of Analysis Mar 24, 2023 E124386
E2316450 Certificate of Analysis Mar 24, 2023 E124386
E23161205 Certificate of Analysis Mar 24, 2023 E124386

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Chemical and Physical Properties

Molecular Weight 314.380 g/mol
XLogP3 1.600
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 9
Exact Mass 314.184 Da
Monoisotopic Mass 314.184 Da
Topological Polar Surface Area 108.000 Ų
Heavy Atom Count 22
Formal Charge 0
Complexity 422.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

Reviews

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