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DS-7423 - 10mM in DMSO, high purity , CAS No.1222104-37-1(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 1222104-37-1(DMSO)
Molecular Weight: 520.51

In stock

Item Number

D656862

Grouped product items
SKU	Size	Availability	Price	Qty
D656862-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$515.90

View related series

Compound libraries (12325) mTOR (145) PI3K (243) PI3K/Akt/mTOR (765)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	DS-7423 is a dual PI3K and mTOR inhibitor, with IC 50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR , respectively. DS-7423 possesses anti-tumor activity.
Storage Temp	Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	DS-7423 is a dual PI3K and mTOR inhibitor, with IC 50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR , respectively. DS-7423 possesses anti-tumor activity. In Vitro DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells. DS-7423 also inhibits other isoforms of class I PI3K (IC 50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Names and Identifiers

Smiles	CC(N1[C@H](C)CN(C2=NC3=C(N4CCOCC4)N=C(C5=CN=C(N)N=C5)N=C3N2CC(F)(F)F)CC1)=O
Molecular Weight	520.51

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