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Dihydromyricetin - >97.0%(HPLC), high purity , CAS No.27200-12-0

23 Citations COA COA
In stock
Item Number
D299476
Grouped product items
SKU Size
Availability
 Price Qty
D299476-250mg
250mg
8
$9.90
D299476-1g
1g
8
$19.90
D299476-5g
5g
5
$59.90
D299476-25g
25g
2
$209.90
D299476-50g
50g
2
$339.90
D299476-100g
100g
1
$539.90
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View related series
Anti-infection (2803) Autophagy (1917) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) DNA/RNA Synthesis (362) Influenza Virus (253) mTOR (145) Phenylpropanoids (153) PI3K/Akt/mTOR (765) Six-Membered Heterocyclic Compounds (1696) Virus (1811)

Basic Description

Synonyms (2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one | HY-N0112 | Dihydromyricetin (Ampeloptin) | SW219328-1 | (+)-Dihydromyricetin | AKOS022168215 | AS-71702 | Dihydromyricetin | dihydro-myricetin | (2r,3r)-3,5,7-trihydro
Specifications & Purity Moligand™, ≥97%(HPLC)
Biochemical and Physiological Mechanisms Dihydromyricetin possesses anti-inflammatory action.
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Product Description

Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2).

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Flavonoids
Subclass Flavans
Intermediate Tree Nodes Flavan-3-ols - Catechins
Direct Parent Epigallocatechins
Alternative Parents 3'-hydroxyflavonoids  3-hydroxyflavonoids  4'-hydroxyflavonoids  5-hydroxyflavonoids  Flavanonols  7-hydroxyflavonoids  Chromones  Pyrogallols and derivatives  Aryl alkyl ketones  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Alkyl aryl ethers  Benzene and substituted derivatives  Vinylogous acids  Secondary alcohols  Oxacyclic compounds  Polyols  Hydrocarbon derivatives  Organic oxides  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Epigallocatechin - 3'-hydroxyflavonoid - 3-hydroxyflavonoid - 4'-hydroxyflavonoid - 5-hydroxyflavonoid - 7-hydroxyflavonoid - Flavanone - Flavanonol - Hydroxyflavonoid - Chromone - Chromane - Benzopyran - 1-benzopyran - Benzenetriol - Pyrogallol derivative - Aryl alkyl ketone - Aryl ketone - Phenol - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - 1-hydroxy-4-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Vinylogous acid - Ketone - Secondary alcohol - Polyol - Ether - Organoheterocyclic compound - Oxacycle - Alcohol - Hydrocarbon derivative - Organooxygen compound - Organic oxygen compound - Organic oxide - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as epigallocatechins. These are compounds containing epigallocatechin or a derivative. Epigallocatechin is a flavan-3-ol containing a benzopyran-3,5,7-triol linked to a 3,4,5-hydroxyphenyl moiety.
External Descriptors Dihyroflavonols

Associated Targets(Human)

APP Tclin Amyloid-beta A4 protein (8510 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-OV-3 (52876 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BT-549 (31254 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SYNJ2 Tchem Synaptojanin-2 (76 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
C6 (2371 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BV-2 (3710 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488188335
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488188335
IUPAC Name (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
INCHI InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
InChIKey KJXSIXMJHKAJOD-LSDHHAIUSA-N
Smiles C1=C(C=C(C(=C1O)O)O)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O
Isomeric SMILES C1=C(C=C(C(=C1O)O)O)[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O
WGK Germany 3
Molecular Weight 320.25
Reaxy-Rn 332335
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=332335&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

34 results found

Lot Number Certificate Type Date Item
E2516099 Certificate of Analysis May 26, 2025 D299476
H2316501 Certificate of Analysis May 12, 2025 D299476
H2316503 Certificate of Analysis May 12, 2025 D299476
H2316504 Certificate of Analysis May 12, 2025 D299476
E2522282 Certificate of Analysis May 09, 2025 D299476
E2522283 Certificate of Analysis May 09, 2025 D299476
E2522286 Certificate of Analysis May 09, 2025 D299476
E2522284 Certificate of Analysis May 09, 2025 D299476
F2503630 Certificate of Analysis May 09, 2025 D299476
E2308858 Certificate of Analysis Feb 07, 2025 D299476
E2308843 Certificate of Analysis Feb 07, 2025 D299476
E2308456 Certificate of Analysis Feb 07, 2025 D299476
E2308452 Certificate of Analysis Feb 07, 2025 D299476
E23081142 Certificate of Analysis Feb 07, 2025 D299476
E23081368 Certificate of Analysis Feb 07, 2025 D299476
E23081282 Certificate of Analysis Feb 07, 2025 D299476
E23081157 Certificate of Analysis Feb 07, 2025 D299476
E23081147 Certificate of Analysis Feb 07, 2025 D299476
F2228277 Certificate of Analysis Apr 02, 2024 D299476
D2428026 Certificate of Analysis Jul 29, 2023 D299476
H2316502 Certificate of Analysis Jul 29, 2023 D299476
H2316505 Certificate of Analysis Jul 29, 2023 D299476
A2507208 Certificate of Analysis Jul 29, 2023 D299476
H2407132 Certificate of Analysis Jul 29, 2023 D299476
H2120272 Certificate of Analysis May 12, 2023 D299476
E23081359 Certificate of Analysis Apr 23, 2023 D299476
E2308874 Certificate of Analysis Apr 23, 2023 D299476
E2308859 Certificate of Analysis Apr 23, 2023 D299476
J2021071 Certificate of Analysis Aug 05, 2022 D299476
C2306509 Certificate of Analysis Jun 04, 2022 D299476
F2228279 Certificate of Analysis Jun 04, 2022 D299476
F2228280 Certificate of Analysis Jun 04, 2022 D299476
F2228278 Certificate of Analysis Jun 04, 2022 D299476
F2228281 Certificate of Analysis Jun 04, 2022 D299476

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Chemical and Physical Properties

Solubility DMSO: ≥5 mg/mL (warmed)
Sensitivity light sensitive;Hygroscopic
Specific Rotation[α] +15.5 to +17.0 deg(C=0.9, methanol)
Melt Point(°C) 248 °C
Molecular Weight 320.250 g/mol
XLogP3 1.100
Hydrogen Bond Donor Count 6
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 1
Exact Mass 320.053 Da
Monoisotopic Mass 320.053 Da
Topological Polar Surface Area 148.000 Ų
Heavy Atom Count 23
Formal Charge 0
Complexity 445.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

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Solution Calculators

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