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Dehydroevodiamine hydrochloride - 99%, high purity , CAS No.111664-82-5

COA

Grade & Purity:

≥99%

Cas Number: 111664-82-5
Molecular Weight: 337.8

In stock

Item Number

D413069

Grouped product items
SKU	Size	Availability	Price
D413069-5mg	5mg	3	$48.90
D413069-25mg	25mg	2	$220.90
D413069-100mg	100mg	1	$793.90

AChE Selective Inhibitors

View related series

COX (258) Immunology/Inflammation (1929) NF-κB (747) NO Synthase (134) PGE synthase (25)

Basic Description

Synonyms	Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,14-dihydro-14-methyl-,hydrochloride (1:1)
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibitAChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production. Targets AChE In vitro Dehydroevodiamine·HCl (DHED) treatment significantly recovers the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. It decreases intracellular calcium levels in primary cortical neurons. In vivo Dehydroevodiamine·HCl (DHED) can improve stress-induced memory impairments and depression-like behaviors. DHED significantly improves learning and memory in the Aβ_1-42-infused rat model. Antiamnestic effects of DHED occur through an improvement of learning and memory and an inhibition of neuronal dysfunction in a scopolamine-induced amnesic rat model. Furthermore, Dehydroevodiamine·HCl (DHED) has hypotensive and neuroprotective effects and modulates nitric oxide production. Cell Research(from reference) Cell lines：primary cortical neurons Concentrations：0.5 and 1 µM Incubation Time：4 h

Product Properties

ALogP	2.891
hba_count	2

Names and Identifiers

Smiles	Cl.CN1C2=CC=CC=C2C(=O)N3CCC4=C5C=CC=CC5=NC4=C13
Molecular Weight	337.8
Reaxy-Rn	5326818
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5326818&ln=

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3 results found

Lot Number	Certificate Type	Date	Item
I2207401	Certificate of Analysis	Jun 10, 2025	D413069
I2207402	Certificate of Analysis	Jun 10, 2025	D413069
I2207400	Certificate of Analysis	Jun 10, 2025	D413069

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 37 mg/mL (109.53 mM);
Sensitivity	light sensitive;Moisture sensitive
DMSO(mg / mL) Max Solubility	37
DMSO(mM) Max Solubility	109.5322676

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