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Basic Information
ID: ALA1667851
Journal: Bioorg Med Chem Lett
Title: Synthesis and pharmacological evaluation of the individual stereoisomers of 3-[methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent.
Authors: Byrne AJ, Byrne AJ, Barlow JW, Walsh JJ.
Abstract: Each stereoisomer of 3-[methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, 1a-d, was prepared and evaluated in vitro for its ability to prevent mediator release induced by different degranulating agents from rodent mast cells and also in vivo against passive cutaneous anaphylaxis. The manner in which the stereoisomers prevented direct membrane activation was found to be highly dependent on the stereochemistry of the individual isomers. Stereoisomer 1b was the most active isomer in vivo, exhibiting superior activity to disodium cromoglycate.
CiteXplore: 21273065
DOI: 10.1016/j.bmcl.2010.12.095
Patent ID: ┄
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