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Cys-McMMAF - 99%, high purity , CAS No.1160590-05-5

COA

Grade & Purity:

≥99%

Cas Number: 1160590-05-5
Molecular Weight: 1046.32

In stock

Item Number

C647381

Grouped product items
SKU	Size	Availability	Price	Qty
C647381-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$440.90
C647381-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,100.90

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Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF ( HY-15579 ) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-D
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models). In Vivo Cys-McMMAF (0.3 mg/kg, 3 mg/kg; i.v.; single dose) has a poor stability with short decline time in cynomolgus monkeys . Pharmacokinetic Analysis in Nude (nu/nu) Mice Model/IV Dose (mg/kg) C max (ng/mL) T max (hr) AUC 0-336 (ng·h/mL) t 1/2 (day) Non-Tumor 1 0.192 8 14.6 2.1 Tumor 1 0.146 8 28.2 6.0 Non-Tumor 10 0.951 8 58.5 3.0 Tumor 10 0.945 8 81.9/td> 2.9 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Names and Identifiers

Smiles	OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(CCCCCN3C(C(CC3=O)SC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)OC)=O)=O
Molecular Weight	1046.32

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