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cholest-5-ene-3,25-diol - >99%, high purity , CAS No.2140-46-7, Agonist of GPR183;Agonist of RAR-related orphan receptor-γ

2 Citations COA COA
In stock
Item Number
C130176
Grouped product items
SKU Size
Availability
 Price Qty
C130176-5mg
5mg
1
$53.90
C130176-10mg
10mg
2
$75.90
C130176-25mg
25mg
1
$118.90
C130176-50mg
50mg
2
$184.90
C130176-100mg
100mg
2
$293.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Biologically active cholesterol metabolite

View related series
Endogenous Metabolite (959) GPR183 Agonist (8) Metabolic Enzyme/Protease (4860) Metabolite (5307) RAR-related orphan receptor-γ Agonist (16)

Basic Description

Synonyms (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | DTXCID3024023 | PD005887 | BDBM20182 | GTPL2885 | MFCD00057815 | Cholest-5-ene-3beta,25-diol | (
Specifications & Purity Moligand™, ≥99%
Biochemical and Physiological Mechanisms 25-Hydroxycholesterol is a side chain oxysterol that has been reported to trigger the activation of many cholesterol molecules. This triggers their movement from the cell membrane to the endoplasmic reticulum (ER). 25-Hydroxycholesterol affects the immune
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type AGONIST
Mechanism of action Agonist of GPR183;Agonist of RAR-related orphan receptor-γ
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Application：

25-Hydroxycholesterol was used to treat mouse neuroblastoma cells to activate the ABCA1 signaling and in studies related to fatty acid metabolism.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Lipids and lipid-like molecules
Class Steroids and steroid derivatives
Subclass Cholestane steroids
Intermediate Tree Nodes Not available
Direct Parent Cholesterols and derivatives
Alternative Parents 3-beta-hydroxysteroids  3-beta-hydroxy delta-5-steroids  Delta-5-steroids  Tertiary alcohols  Secondary alcohols  Cyclic alcohols and derivatives  Hydrocarbon derivatives  
Molecular Framework Aliphatic homopolycyclic compounds
Substituents Cholesterol - Cholesterol-skeleton - 25-hydroxysteroid - 3-beta-hydroxy-delta-5-steroid - Hydroxysteroid - 3-hydroxy-delta-5-steroid - 3-hydroxysteroid - 3-beta-hydroxysteroid - Delta-5-steroid - Tertiary alcohol - Cyclic alcohol - Secondary alcohol - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Alcohol - Aliphatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as cholesterols and derivatives. These are compounds containing a 3-hydroxylated cholestane core.
External Descriptors Cholesterol and derivatives

Associated Targets(Human)

CRYAB Tchem Alpha-crystallin B chain (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
SREBF2 Tchem Sterol regulatory element-binding protein 2 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
RORC Tchem Nuclear receptor ROR-gamma (4 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
GPR183 Tchem G-protein coupled receptor 183 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NPC1L1 Tclin Niemann-Pick C1-like protein 1 (346 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NR1H3 Tchem LXR-alpha (2891 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NPC1 Tchem Niemann-Pick C1 protein (18985 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SREBF2 Tchem Sterol regulatory element-binding protein 2 (50 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-V/beta-3 (2708 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate NMDA receptor; GRIN1/GRIN2B (726 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate NMDA receptor; GRIN1/GRIN2A (719 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CRYAB Tchem Alpha-crystallin B chain (132 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CRYAA Tchem Alpha-crystallin A chain (85 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CRYBB2 Tbio Beta-crystallin B2 (41 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CRYGC Tbio Gamma-crystallin C (41 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mycobacterium tuberculosis (203094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Vero (26788 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Srebf1 Sterol regulatory element-binding protein 1 (3 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488183663
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488183663
IUPAC Name (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
INCHI InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
InChIKey INBGSXNNRGWLJU-ZHHJOTBYSA-N
Smiles CC(CCCC(C)(C)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
Isomeric SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
WGK Germany 1
Molecular Weight 402.653
Beilstein 3161260
Reaxy-Rn 2062312
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2062312&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number Certificate Type Date Item
F2518072 Certificate of Analysis Jul 02, 2025 C130176
B2303147 Certificate of Analysis Nov 19, 2024 C130176
B2303139 Certificate of Analysis Nov 19, 2024 C130176
B2303145 Certificate of Analysis Nov 19, 2024 C130176
B2303146 Certificate of Analysis Nov 19, 2024 C130176
B2303144 Certificate of Analysis Nov 08, 2024 C130176
B2303143 Certificate of Analysis Nov 08, 2024 C130176
B2303142 Certificate of Analysis Nov 08, 2024 C130176
J1815061 Certificate of Analysis Apr 07, 2024 C130176
J1815062 Certificate of Analysis Apr 07, 2024 C130176
D2127061 Certificate of Analysis Feb 09, 2023 C130176
H2420042 Certificate of Analysis Dec 09, 2022 C130176

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Chemical and Physical Properties

Flash Point(°F) 14 °C
Flash Point(°C) 14°C
Molecular Weight 402.700 g/mol
XLogP3 6.800
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 5
Exact Mass 402.35 Da
Monoisotopic Mass 402.35 Da
Topological Polar Surface Area 40.500 Ų
Heavy Atom Count 29
Formal Charge 0
Complexity 636.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 8
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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