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Chlorotrimethylsilane - ≥99.0%(GC), high purity , CAS No.75-77-4

166 Citations COA COA
    Grade & Purity:
  • ≥99%(GC)
In stock
Item Number
C104814
Grouped product items
SKU Size
Availability
 Price Qty
C104814-100ml
100ml
3
$14.90
C104814-250ml
250ml
3
$29.90
C104814-500ml
500ml
3
$49.90
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Bulk Order  SDS  DATASHEET  Specification Sheet
View related series
Clorosilanes (2) Monochlorosilanes (2) Oligosaccharide Cynthesis Reagent (16) Silylation Reagents (42)

Basic Description

Synonyms TMCS | Trimethyl chlorosilane | Silane, chlorotrimethyl- | TRIMETHYLCHLOROSILANE | Trimethylsilyl chloride | chloro(trimethyl)silane | Silane, trimethylchloro- | Silicane, chlorotrimethyl- | Chlorotrimethylsilane | TMSCl | Monochlorotrimethylsilicon
Specifications & Purity ≥99%(GC)
Storage Temp Argon charged
Shipped In Normal
Product Description

Used in Fisher Glycosylation


Application：

Chlorotrimethylsilane is used to silanize laboratory glassware, which makes the surfaces more lipophilic. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organometallic compounds
Class Organometalloid compounds
Subclass Organosilicon compounds
Intermediate Tree Nodes Organoheterosilanes - Trialkylheterosilanes
Direct Parent Trialkylchlorosilanes
Alternative Parents Silyl monohalides  Organochlorosilanes  Organic metalloid salts  Alkylhalosilanes  Hydrocarbon derivatives  
Molecular Framework Aliphatic acyclic compounds
Substituents Trialkylchlorosilane - Silyl monohalide - Organochlorosilane - Organic metalloid salt - Alkylhalosilane - Hydrocarbon derivative - Organic salt - Aliphatic acyclic compound
Description This compound belongs to the class of organic compounds known as trialkylchlorosilanes. These are organoheterosilanes, bearing a silicon atom linked to three alkyl groups and one chlorine atom.
External Descriptors silyl chloride

Associated Targets(Human)

AR Tclin Androgen Receptor (11781 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name chloro(trimethyl)silane
INCHI InChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
InChIKey IJOOHPMOJXWVHK-UHFFFAOYSA-N
Smiles C[Si](C)(C)Cl
Isomeric SMILES C[Si](C)(C)Cl
WGK Germany 2
RTECS VV2710000
UN Number 1298
Packing Group II
Molecular Weight 108.64
Beilstein 1209232
Reaxy-Rn 1209232
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1209232&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

75 results found

Lot Number Certificate Type Date Item
B2525106 Certificate of Analysis Jun 11, 2025 C104814
B2525114 Certificate of Analysis Jun 11, 2025 C104814
B2525113 Certificate of Analysis Jun 11, 2025 C104814
B2525092 Certificate of Analysis Jun 11, 2025 C104814
E2520176 Certificate of Analysis Apr 25, 2025 C104814
E2508139 Certificate of Analysis Apr 25, 2025 C104814
E2508140 Certificate of Analysis Apr 25, 2025 C104814
E2520175 Certificate of Analysis Apr 25, 2025 C104814
E2508138 Certificate of Analysis Apr 25, 2025 C104814
E2520177 Certificate of Analysis Apr 25, 2025 C104814
E2520182 Certificate of Analysis Apr 25, 2025 C104814
L2410229 Certificate of Analysis Mar 04, 2025 C104814
L2410392 Certificate of Analysis Mar 04, 2025 C104814
L2410393 Certificate of Analysis Mar 04, 2025 C104814
C2427131 Certificate of Analysis Jan 14, 2025 C104814
H2407129 Certificate of Analysis Nov 14, 2024 C104814
G2404228 Certificate of Analysis Oct 23, 2024 C104814
G2404229 Certificate of Analysis Oct 23, 2024 C104814
G2404231 Certificate of Analysis Oct 23, 2024 C104814
H2415013 Certificate of Analysis Aug 22, 2024 C104814
C2427132 Certificate of Analysis Jul 18, 2024 C104814
C2427133 Certificate of Analysis Jul 18, 2024 C104814
C2427135 Certificate of Analysis Jul 18, 2024 C104814
G2404227 Certificate of Analysis Jul 18, 2024 C104814
L2325120 Certificate of Analysis Apr 03, 2024 C104814
L2325121 Certificate of Analysis Apr 03, 2024 C104814
L2325123 Certificate of Analysis Apr 03, 2024 C104814
L2325124 Certificate of Analysis Apr 03, 2024 C104814
C2427134 Certificate of Analysis Mar 19, 2024 C104814
K2324065 Certificate of Analysis Mar 19, 2024 C104814
I2328113 Certificate of Analysis Jan 17, 2024 C104814
F2320190 Certificate of Analysis Oct 19, 2023 C104814
I2328141 Certificate of Analysis Sep 19, 2023 C104814
I2328111 Certificate of Analysis Sep 19, 2023 C104814
I2328112 Certificate of Analysis Sep 19, 2023 C104814
I2328117 Certificate of Analysis Sep 19, 2023 C104814
F2320191 Certificate of Analysis Jun 09, 2023 C104814
F2320193 Certificate of Analysis Jun 09, 2023 C104814
F2320186 Certificate of Analysis Jun 09, 2023 C104814
F2320184 Certificate of Analysis Jun 09, 2023 C104814
E2319150 Certificate of Analysis May 09, 2023 C104814
E2319145 Certificate of Analysis May 09, 2023 C104814
E2319154 Certificate of Analysis May 09, 2023 C104814
E2319144 Certificate of Analysis May 09, 2023 C104814
E2319155 Certificate of Analysis May 09, 2023 C104814
L2207041 Certificate of Analysis Mar 14, 2023 C104814
L2207078 Certificate of Analysis Mar 14, 2023 C104814
H2206850 Certificate of Analysis Feb 13, 2023 C104814
J2226163 Certificate of Analysis Feb 09, 2023 C104814
L2207034 Certificate of Analysis Nov 22, 2022 C104814
L2207040 Certificate of Analysis Nov 22, 2022 C104814
J2226164 Certificate of Analysis Oct 12, 2022 C104814
J2226165 Certificate of Analysis Oct 12, 2022 C104814
J2226160 Certificate of Analysis Oct 12, 2022 C104814
J2226166 Certificate of Analysis Oct 12, 2022 C104814
A2207120 Certificate of Analysis Aug 12, 2022 C104814
A2207121 Certificate of Analysis Aug 12, 2022 C104814
A2207128 Certificate of Analysis Aug 12, 2022 C104814
C2230013 Certificate of Analysis Jul 14, 2022 C104814
C2230003 Certificate of Analysis Jul 14, 2022 C104814
H2206851 Certificate of Analysis Jul 07, 2022 C104814
H2206852 Certificate of Analysis Jul 07, 2022 C104814
H2206853 Certificate of Analysis Jul 07, 2022 C104814
H2208016 Certificate of Analysis Jul 07, 2022 C104814
I2214162 Certificate of Analysis Jul 07, 2022 C104814
A2207129 Certificate of Analysis May 06, 2022 C104814
H2031033 Certificate of Analysis Apr 14, 2022 C104814
E2202033 Certificate of Analysis Mar 12, 2022 C104814
C2230005 Certificate of Analysis Mar 12, 2022 C104814
E2202035 Certificate of Analysis Mar 12, 2022 C104814
C2230010 Certificate of Analysis Mar 12, 2022 C104814
E2202025 Certificate of Analysis Mar 12, 2022 C104814
K2103739 Certificate of Analysis Mar 10, 2022 C104814
I2118026 Certificate of Analysis Jan 11, 2022 C104814
F2102138 Certificate of Analysis May 08, 2021 C104814

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Chemical and Physical Properties

Solubility Miscible with ether, benzene, diethylether and perchloroethylene.
Sensitivity Moisture sensitive.
Refractive Index 1.3884
Flash Point(°F) -4 °F
Flash Point(°C) -28℃
Boil Point(°C) 57°C
Melt Point(°C) -40°C
Molecular Weight 108.640 g/mol
XLogP3
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 0
Rotatable Bond Count 0
Exact Mass 108.016 Da
Monoisotopic Mass 108.016 Da
Topological Polar Surface Area 0.000 Ų
Heavy Atom Count 5
Formal Charge 0
Complexity 28.400
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

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    Chlorotrimethylsilane
    • ≥98%(GC)

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  2. Chlorotrimethylsilane
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