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Cefcapene pivoxil hydrochloride - 99%, high purity , CAS No.147816-23-7

    Grade & Purity:
  • ≥99%
In stock
Item Number
C647456
Grouped product items
SKU Size
Availability
Price Qty
C647456-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$75.90
C647456-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$123.90
C647456-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$200.90

Basic Description

Synonyms Flomox | MFCD00883711 | A925072 | 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-(carbamoyloxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrochloride | CEFCAPENE PIVOXIL HYDROCHLORIDE
Specifications & Purity ≥99%
Biochemical and Physiological Mechanisms Cefcapene pivoxil hydrochloride, an antibiotic , is an orally active and potent 3rd-generation cephalosporin with a wide spectrum of anti-bacterial activity.Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) tr
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Cefcapene pivoxil hydrochloride, an antibiotic , is an orally active and potent 3rd-generation cephalosporin with a wide spectrum of anti-bacterial activity Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) treatment .

In Vivo

Cefcapene pivoxil hydrochloride (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×10 9 CFU)Dosage: 100 mg/kg Administration: Oral administration; 100mg/kg; 4 days Result: Was against H. influenzae colonization in mouse lung.

Form:Solid

IC50& Target:β-lactam

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Lactams
Subclass Beta lactams
Intermediate Tree Nodes Cephems - Cephalosporins
Direct Parent Cephalosporin 3'-carbamates
Alternative Parents N-acyl-alpha amino acids and derivatives  2,4-disubstituted thiazoles  Acylals  1,3-thiazines  2-amino-1,3-thiazoles  Dicarboxylic acids and derivatives  N-acyl amines  Tertiary carboxylic acid amides  Carbamate esters  Enoate esters  Heteroaromatic compounds  Secondary carboxylic acid amides  Azetidines  Organic carbonic acids and derivatives  Dialkylthioethers  Thiohemiaminal derivatives  Azacyclic compounds  Acetals  Carbonyl compounds  Organic oxides  Organopnictogen compounds  Primary amines  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Cephalosporin 3'-carbamate - N-acyl-alpha amino acid or derivatives - Alpha-amino acid or derivatives - 2,4-disubstituted 1,3-thiazole - Acylal - Meta-thiazine - Dicarboxylic acid or derivatives - N-acyl-amine - 1,3-thiazol-2-amine - Azole - Heteroaromatic compound - Tertiary carboxylic acid amide - Alpha,beta-unsaturated carboxylic ester - Enoate ester - Carbamic acid ester - Thiazole - Amino acid or derivatives - Azetidine - Carboxamide group - Carboxylic acid ester - Carbonic acid derivative - Secondary carboxylic acid amide - Thioether - Hemithioaminal - Dialkylthioether - Azacycle - Acetal - Carboxylic acid derivative - Organonitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organic oxygen compound - Organooxygen compound - Primary amine - Organic nitrogen compound - Hydrochloride - Amine - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as cephalosporin 3'-carbamates. These are cephalosporins that are substituted at the 3'-position by a carbamate group.
External Descriptors Not available

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-(carbamoyloxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;hydrochloride
INCHI InChI=1S/C23H29N5O8S2.ClH/c1-5-6-12(13-9-38-21(24)26-13)16(29)27-14-17(30)28-15(11(7-34-22(25)33)8-37-18(14)28)19(31)35-10-36-20(32)23(2,3)4;/h6,9,14,18H,5,7-8,10H2,1-4H3,(H2,24,26)(H2,25,33)(H,27,29);1H/b12-6-;/t14-,18-;/m1./s1
InChIKey ALPFRUJYOAKQQR-CQZSJNSUSA-N
Smiles CCC=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)OCOC(=O)C(C)(C)C.Cl
Isomeric SMILES CC/C=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)OCOC(=O)C(C)(C)C.Cl
PubChem CID 6918126
Molecular Weight 604.1

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Solubility DMSO : 125 mg/mL (206.92 mM; Need ultrasonic) H2O : <0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Melt Point(°C) >191° C (dec.)
Molecular Weight 604.100 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 12
Rotatable Bond Count 13
Exact Mass 603.122 Da
Monoisotopic Mass 603.122 Da
Topological Polar Surface Area 247.000 Ų
Heavy Atom Count 39
Formal Charge 0
Complexity 1060.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 1
Covalently-Bonded Unit Count 2

Solution Calculators

Reviews

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