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CD278/ICOS Rat mAb - Primary antibody, specific to CD278/ICOS, Rat IgG2b

COA COA
    Application:
  • Animal Model
  • Blocking
  • Flow Cytometry
  • Functional Assay
  • Host species: Rat
  • Reactive species: Mouse
  • Isotype: Rat IgG2b
  • Clone Number: 7E.17G9
  • Conjugation: Unconjugated
In stock
Item Number
Ab109273
Grouped product items
SKU Size
Availability
 Price Qty
Ab109273-10μg
10μg
9
$29.90
Ab109273-50μg
50μg
4
$69.90
Ab109273-100μg
100μg
2
$99.90
Ab109273-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$229.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (7E.17G9); Rat anti Mouse CD278/ICOS Antibody; in vivo blocking of ICOS/ICOSL signaling, Flow; Unconjugated

View related series
Click to view target information: ICOS
Accession#: Q9WVS0 (1) CD278 (11) Flow Cytometry (1158) Gene ID: 54167 (1) ICOS (11)

Basic Description

Product Name CD278/ICOS Rat mAb - Primary antibody, specific to CD278/ICOS, Rat IgG2b
Synonyms H4 | CCLP | Ly115 | Activation-inducible lymphocyte immunomediatory molecule | AILIM | AILIMCD278 | CD278 antigen | CD278 | CRP-1 | CVID1 | ICOS | inducible costimulator | inducible T-cell costimulator | inducible T-cell co-stimulator | MGC39850 | Activat
Specifications & Purity Carrier Free, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Rat
Specificity CD278/ICOS
Immunogen Mouse ICOS cDNA and ICOS hexahistidine fusion protein
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Rat anti Mouse CD278/ICOS Antibody, Monoclonal (7E.17G9), could be used for in vivo blocking of ICOS/ICOSL signaling, Flow and so on.
Application
Flow: Use at an assay dependent concentration.
in vivo blocking of ICOS/ICOSL signaling: Use at an assay dependent concentration.
Protein Function
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Product Properties

Isotype Rat IgG2b
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

ICOS Tbio Inducible T-cell costimulator (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

CD278/ICOS Rat mAb (Ab109273) - Flow Cytometry
Two-color flow cytometric analysis of CD278/ICOS expression on mouse splenocytes. Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) C57BL/6 mouse spleen cells were stained with CD4 Rat mAb (FITC) (Ab181110) and CD278/ICOS Rat mAb (Ab109273) at 0.5 μg/mL. Two-color flow cytometric dot plots showing the correlated expression of CD4 versus CD278/ICOS (or Isotype control staining) were derived from gated events with the forward and side light-scatter characteristics of viable mononuclear cells.

Application

Application Dilution info
Flow Cytometry

Use at an assay dependent concentration.
in vivo blocking of ICOS/ICOSL signaling

Use at an assay dependent concentration.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0708833 Certificate of Analysis Jul 26, 2024 Ab109273
ZJ24F0708832 Certificate of Analysis Jul 26, 2024 Ab109273
ZJ24F0708831 Certificate of Analysis Jul 26, 2024 Ab109273

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