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CCX354 - 99%, high purity , C-C chemokine receptor type 1 antagonist, CAS No.1010073-75-2, C-C chemokine receptor type 1 antagonist

COA

Grade & Purity:

≥98%

Cas Number: 1010073-75-2
Molecular Weight: 451.91
PubChem CID: 135565361

In stock

Item Number

C647638

Grouped product items
SKU	Size	Availability	Price
C647638-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$275.90
C647638-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$660.90
C647638-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$937.90
C647638-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,405.90
C647638-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,880.90

View related series

CCR (85) Class A GPCR (4138) GPCR/G Protein (3172) Immunology/Inflammation (1929)

Basic Description

Synonyms	ZIMLRKWQDLVPEK-UHFFFAOYSA-N \| CCR1 antagonist 1 \| MS-28213 \| 1359144-02-7 \| GSK2941266 \| GSK-2941266 \| SCHEMBL1638749 \| 1010073-75-2 \| CCX354 \| CCX-354 \| Ethanone, 1-(4-(4-chloro-3-methoxyphenyl)-1-piperazinyl)-2-(3-(1H-imidazol-2-yl)-1H-pyrazolo(3,4-b)py
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	CCX354 is an antagonist of CCR1 , with anti-inflammatory activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	ANTAGONIST
Mechanism of action	C-C chemokine receptor type 1 antagonist
Product Description	CCX354 is an antagonist of CCR1 , with anti-inflammatory activity. In Vitro CCX354 shows potent activities in the chemotaxis assay, with IC 50 < 100 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In vivo, CCX354 has in vivo anti-inflammatory activity and has superior pharmacokinetic properties . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CCR1

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazinanes
    - Subclass Piperazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazinanes
Subclass	Piperazines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpiperazines
Alternative Parents	N-arylpiperazines Methoxyanilines Pyrazolopyridines Aminophenyl ethers Dialkylarylamines Anisoles Methoxybenzenes Phenoxy compounds Chlorobenzenes Alkyl aryl ethers Pyridines and derivatives Aryl chlorides Tertiary carboxylic acid amides Imidazoles Pyrazoles Heteroaromatic compounds Amino acids and derivatives Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organochlorides Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenylpiperazine - N-arylpiperazine - Pyrazolopyridine - Aminophenyl ether - Methoxyaniline - Anisole - Phenol ether - Phenoxy compound - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Methoxybenzene - Chlorobenzene - Alkyl aryl ether - Halobenzene - Aryl halide - Benzenoid - Aryl chloride - Monocyclic benzene moiety - Pyridine - Heteroaromatic compound - Azole - Tertiary carboxylic acid amide - Imidazole - Pyrazole - Carboxamide group - Amino acid or derivatives - Tertiary amine - Carboxylic acid derivative - Azacycle - Ether - Organic nitrogen compound - Organohalogen compound - Organochloride - Carbonyl group - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpiperazines. These are compounds containing a phenylpiperazine skeleton, which consists of a piperazine bound to a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	2.5

Associated Targets(Human)

CCR1 Tchem C-C chemokine receptor type 1 (2 Activities)

Discover Target: CCR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCR1 Tchem C-C chemokine receptor type 1 (1730 Activities)

Discover Target: CCR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-[3-(1H-imidazol-2-yl)pyrazolo[3,4-b]pyridin-1-yl]ethanone
INCHI	InChI=1S/C22H22ClN7O2/c1-32-18-13-15(4-5-17(18)23)28-9-11-29(12-10-28)19(31)14-30-22-16(3-2-6-26-22)20(27-30)21-24-7-8-25-21/h2-8,13H,9-12,14H2,1H3,(H,24,25)
InChIKey	ZIMLRKWQDLVPEK-UHFFFAOYSA-N
Smiles	COC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C4=C(C=CC=N4)C(=N3)C5=NC=CN5)Cl
Isomeric SMILES	COC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CN3C4=C(C=CC=N4)C(=N3)C5=NC=CN5)Cl
Alternate CAS	1359144-02-7,1010073-75-2
PubChem CID	135565361
Molecular Weight	451.91

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
F2506351	Certificate of Analysis	Nov 13, 2024	C647638
F2506352	Certificate of Analysis	Nov 13, 2024	C647638
F2506356	Certificate of Analysis	Nov 13, 2024	C647638
F2506357	Certificate of Analysis	Nov 13, 2024	C647638
F2506350	Certificate of Analysis	Nov 13, 2024	C647638
F2506353	Certificate of Analysis	Nov 13, 2024	C647638
F2506354	Certificate of Analysis	Nov 13, 2024	C647638
F2506355	Certificate of Analysis	Nov 13, 2024	C647638
F2506358	Certificate of Analysis	Nov 13, 2024	C647638
F2506360	Certificate of Analysis	Nov 13, 2024	C647638

Chemical and Physical Properties

Molecular Weight	451.900 g/mol
XLogP3	2.500
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	451.152 Da
Monoisotopic Mass	451.152 Da
Topological Polar Surface Area	92.200 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	650.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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