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(+)-Catechin hydrate - ≥96.0% (sum of enantiomers, HPLC), high purity , CAS No.225937-10-0

    Grade & Purity:
  • ≥96%(HPLC)
  • sum of enantiomers
In stock
Item Number
C464218
Grouped product items
SKU Size
Availability
Price Qty
C464218-1g
1g
2
$133.90
C464218-10g
10g
1
$387.90

Basic Description

Synonyms 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, monohydrate, (2R,3S)- | (+/-)-Catechin hydrate, primary pharmaceutical reference standard | (2R,3S)-2-(3,4-Dihydroxyphenyl)-chroman-3,5,7-triol hydrate | (2R,3S)-2-(3,4-Dihydroxyphenyl)chr
Specifications & Purity ≥96%(HPLC), sum of enantiomers
Storage Temp Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Catechin hydrate is a polyphenolic flavonoid that exhibits antioxidant properties. It is commonly found in green tea, grape seeds, and bark of few trees like acacia and mahogany.(+)-Catechin hydrate can be used:As an inhibitor of steel corrosion in hydrochloric acid solution.As a model compound in the study of antimicrobial activities of flavonoids onEscherichia coli.As a starting material for the synthesis of catechin glucosides of biological importance.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Flavonoids
Subclass Flavans
Intermediate Tree Nodes Flavan-3-ols
Direct Parent Catechins
Alternative Parents 3'-hydroxyflavonoids  3-hydroxyflavonoids  4'-hydroxyflavonoids  5-hydroxyflavonoids  7-hydroxyflavonoids  1-benzopyrans  Catechols  1-hydroxy-2-unsubstituted benzenoids  1-hydroxy-4-unsubstituted benzenoids  Alkyl aryl ethers  Benzene and substituted derivatives  Secondary alcohols  Oxacyclic compounds  Polyols  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Catechin - Hydroxyflavonoid - 7-hydroxyflavonoid - 5-hydroxyflavonoid - 4'-hydroxyflavonoid - 3-hydroxyflavonoid - 3'-hydroxyflavonoid - 1-benzopyran - Chromane - Benzopyran - Catechol - Alkyl aryl ether - Phenol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Secondary alcohol - Oxacycle - Organoheterocyclic compound - Polyol - Ether - Alcohol - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as catechins. These are compounds containing a catechin moiety, which is a 3,4-dihydro-2-chromene-3,5.7-tiol.
External Descriptors hydrate

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALPG Tchem Alkaline phosphatase placental-like (1197 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (1551 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Iap Intestinal alkaline phosphatase (419 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
dnaB Replicative DNA helicase (15 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Large T antigen (1457 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
recA Protein RecA (2211 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol;hydrate
INCHI InChI=1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1
InChIKey OFUMQWOJBVNKLR-NQQJLSKUSA-N
Smiles C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O.O
Isomeric SMILES C1[C@@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O.O
WGK Germany 3
RTECS DJ3450000
Alternate CAS 154-23-4
Molecular Weight 290.27
Beilstein 3595244
Reaxy-Rn 31285846
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31285846&ln=

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number Certificate Type Date Item
J2310405 Certificate of Analysis Sep 21, 2023 C464218
J2310402 Certificate of Analysis Sep 21, 2023 C464218
J2310403 Certificate of Analysis Sep 21, 2023 C464218
J2310404 Certificate of Analysis Sep 21, 2023 C464218

Chemical and Physical Properties

Sensitivity Loss of crystalline water during storage
Melt Point(°C) 96°C(lit.)
Molecular Weight 308.280 g/mol
XLogP3
Hydrogen Bond Donor Count 6
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 1
Exact Mass 308.09 Da
Monoisotopic Mass 308.09 Da
Topological Polar Surface Area 111.000 Ų
Heavy Atom Count 22
Formal Charge 0
Complexity 364.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Alternative Products

Citations of This Product

1. Zijian Liang, Pangzhen Zhang, Wen Ma, Xin-An Zeng, Zhongxiang Fang.  (2024)  Physicochemical properties, antioxidant activities and comprehensive phenolic profiles of tea-macerated Chardonnay wine and model wine.  FOOD CHEMISTRY,  436  (137748). 
2. Tong Jiang, Hong Wang, Peihua Xu, Yifan Yao, Yilong Ma, Zhaojun Wei, Xiangli Niu, Yafang Shang, Dong Zhao.  (2023)  Effect of grape seed proanthocyanidin on the structural and physicochemical properties of bread during bread fermentation stage.  Current Research in Food Science,  (100559). 
3. Mao-Ling Luo, Hua Chen, Guo-Ying Chen, Shengpeng Wang, Yitao Wang, Feng-Qing Yang.  (2023)  Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening.  MOLECULES,  28  (14): (5429). 
4. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou.  (2023)  Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  292  (122380). 
5. Shuai Zhang, Qin Ma, Lihong Dong, Xuchao Jia, Lei Liu, Fei Huang, Guang Liu, Zhida Sun, Jianwei Chi, Mingwei Zhang, Ruifen Zhang.  (2022)  Phenolic profiles and bioactivities of different milling fractions of rice bran from black rice.  FOOD CHEMISTRY,  378  (132035). 
6. Yirong Xia, Xintong Wang, Hechen Sun, Ximing Huang.  (2021)  Proton-coupled electron transfer of catechin in tea wine: the enhanced mechanism of anti-oxidative capacity.  RSC Advances,  11  (63): (39985-39993). 
7. Murtaza Ali, Jun-Hu Cheng, Da-Wen Sun.  (2020)  Effects of dielectric barrier discharge cold plasma treatments on degradation of anilazine fungicide and quality of tomato (Lycopersicon esculentum Mill) juice.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  56  (1): (69-75). 
8. Mengting Wang, Jinyuan Shi, Lei Wang, Yaqin Hu, Xingqian Ye, Donghong Liu, Jianchu Chen.  (2018)  Inhibitory kinetics and mechanism of flavonoids from lotus (Nelumbo nucifera Gaertn.) leaf against pancreatic α-amylase.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  120  (2589). 
9. Juan Xu, Hongpo Zhou, Kun Li, Jinju Ma, Wenwen Zhang, Lanxiang Liu, Yanlin Sun, Hong Zhang, Kai Li.  (2018)  Multi-scale pectin/polyphenol beads for non-fouling fluorescence tracking on soft matter under water.  CARBOHYDRATE POLYMERS,  199  (186). 
10. Rana Muhammad Aadil, Xin-An Zeng, Zhong Han, Amna Sahar, Anees Ahmed Khalil, Ubaid Ur Rahman, Muneeb Khan, Tariq Mehmood.  (2017)  Combined effects of pulsed electric field and ultrasound on bioactive compounds and microbial quality of grapefruit juice.  JOURNAL OF FOOD PROCESSING AND PRESERVATION,  42  (2): (e13507). 
11. Dongwei Wei, Weizhi Huo, Guangmeng Li, Qiuling Xie, Yanbin Jiang.  (2018)  The combined effects of lysozyme and ascorbic acid on microstructure and properties of zein-based films.  CHINESE JOURNAL OF CHEMICAL ENGINEERING,  26  (648). 
12. Lite Yang, Bingjie Xu, Huili Ye, Faqiong Zhao, Baizhao Zeng.  (2017)  A novel quercetin electrochemical sensor based on molecularly imprinted poly(para-aminobenzoic acid) on 3D Pd nanoparticles-porous graphene-carbon nanotubes composite.  SENSORS AND ACTUATORS B-CHEMICAL,  251  (601). 
13. Lele Zhang, Minglei Yang, Junlan Gao, Shan Jin, Zhengyan Wu, Lifang Wu, Xin Zhang.  (2016)  Seasonal variation and gender pattern of phenolic and flavonoid contents in Pistacia chinensis Bunge inflorescences and leaves.  JOURNAL OF PLANT PHYSIOLOGY,  191  (36). 
14. Rana Muhammad Aadil, Xin-An Zeng, Amjad Ali, Feng Zeng, Muhammad Adil Farooq, Zhong Han, Saud Khalid, Saqib Jabbar.  (2015)  Influence of different pulsed electric field strengths on the quality of the grapefruit juice.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  50  (10): (2290-2296). 
15. Rana Muhammad Aadil, Xin-An Zeng, Man-Sheng Wang, Zhi-Wei Liu, Zhong Han, Zhi-Hong Zhang, Jing Hong, Saqib Jabbar.  (2015)  A potential of ultrasound on minerals, micro-organisms, phenolic compounds and colouring pigments of grapefruit juice.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  50  (5): (1144-1150). 
16. Rana Muhammad Aadil, Xin-An Zeng, Zhi-Hong Zhang, Man-Sheng Wang, Zhong Han, Hong Jing, Saqib Jabbar.  (2015)  Thermosonication: a potential technique that influences the quality of grapefruit juice.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  50  (5): (1275-1282). 
17. Yurong Ma, Huihua Huang.  (2014)  Characterisation and comparison of phenols, flavonoids and isoflavones of soymilk and their correlations with antioxidant activity.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  49  (10): (2290-2298). 
18. Mengying He, Ting Wu, Siyi Pan, Xiaoyun Xu.  (2014)  Antimicrobial mechanism of flavonoids against Escherichia coli ATCC 25922 by model membrane study.  APPLIED SURFACE SCIENCE,  305  (515). 
19. Huijie Zhang, Mingqin Kang, Hanqi Zhang, Yong Yu.  (2014)  Matrix solid phase dispersion extraction for determination of flavonoids in the flower of Chrysanthemum morifolium Ramat. by capillary zone electrophoresis.  Analytical Methods,  (3): (766-773). 
20. Obafemi Ibitayo Obajemihi, Jun-Hu Cheng, Da-Wen Sun.  (2024)  Enhancing Moisture Transfer and Quality Attributes of Tomato Slices Through Synergistic Cold Plasma and Osmodehydration Pretreatments During Infrared-Assisted Pulsed Vacuum Drying.  JOURNAL OF FOOD ENGINEERING,    (112335). 
21. Obafemi Ibitayo Obajemihi, Jun-Hu Cheng, Da-Wen Sun.  (2024)  Novel cold plasma functionalized water pretreatment for improving drying performance and physicochemical properties of tomato (Solanum lycopersicum L.) fruits during infrared-accelerated pulsed vacuum drying.  JOURNAL OF FOOD ENGINEERING,    (112050). 
22. Liang Zijian, Zhang Pangzhen, Ma Wen, Zeng Xin-An, Fang Zhongxiang.  (2024)  Quality attributes of black tea-flavored Chardonnay wine processed by ultrasound.  Food Production Processing and Nutrition,  (1): (1-15). 

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