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SIGLEC H Rat mAb - Primary antibody, specific to SIGLEC H, Rat IgG2b

COA COA
    Application:
  • Animal Model
  • Flow Cytometry
  • Functional Assay
  • Host species: Rat
  • Reactive species: Mouse
  • Isotype: Rat IgG2b
  • Clone Number: 440c
  • Conjugation: Unconjugated
In stock
Item Number
Ab127562
Grouped product items
SKU Size
Availability
 Price Qty
Ab127562-10μg
10μg
5
$29.90
Ab127562-50μg
50μg
2
$99.90
Ab127562-100μg
100μg
1
$159.90
Ab127562-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$599.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (440c); Rat anti Mouse SIGLEC H Antibody; Flow, in vivo administration; Unconjugated

View related series
Click to view target information: CD1C
Accession#: Q3Y597 (5) Flow Cytometry (1158) Gene ID: 233274 (5) Siglech (5)

Basic Description

Product Name SIGLEC H Rat mAb - Primary antibody, specific to SIGLEC H, Rat IgG2b
Synonyms sialic acid binding Ig like lectin H antibody | SIGLEC like protein antibody | Siglech antibody | Siglec-H | 6430529G09Rik
Specifications & Purity Carrier Free, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Rat
Specificity SIGLEC H
Immunogen Purified bone marrow-derived IPCs
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Rat anti Mouse SIGLEC H Antibody, Monoclonal (440c), could be used for Flow, in vivo administration and so on.

Application:
Flow: Use at an assay dependent concentration.

in vivo administration: Use at an assay dependent concentration.

Relevance

SIGLEC H a cell-surface receptor molecule selectively expressed on murine natural interferon producing cells (IPC), also called mouse plasmacytoid dendritic cells (pDC). Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo. The monoclonal antibody 440c exclusively recognizes mouse Siglec-H in all lymphoid organs under both normal and inflammatory conditions. Siglec-H is normal present in the T cell zone of lymph nodes and spleen.

Product Properties

Isotype Rat IgG2b
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

CD1C Tbio T-cell surface glycoprotein CD1c (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

SIGLEC H Rat mAb (Ab127562) - Flow Cytometry
Two-color flow cytometric analysis of SIGLEC H expression on mouse splenocytes. BALB/C mouse spleen cells were stained with CD45R Rat mAb (AF647) (Ab191663) and either Rat IgG Isotype Control Antibody (Biotin) (Ab180310; Left panel) or SIGLEC H Rat mAb (Ab127562; Right panel) conjugated with biotin at 0.2 μg/mL for 1 hour at 4°C and detected with SA-PE (rp156150). Two-color flow cytometric dot plots showing the correlated expression of CD45R versus SIGLEC H (or Isotype control staining) were derived from gated events with the forward and side light-scatter characteristics of viable spleen cells.

Application

Application Dilution info
Flow Cytometry

Use at an assay dependent concentration.
in vivo administration

Use at an assay dependent concentration

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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