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Integrin alpha 4/CD49D Rat mAb - Primary antibody, specific to Integrin alpha 4/CD49D, Rat IgG2b

COA COA
    Application:
  • Animal Model
  • Flow Cytometry
  • Functional Assay
  • Neutralization
  • Host species: Rat
  • Reactive species: Human,Mouse
  • Isotype: Rat IgG2b
  • Clone Number: PS/2
  • Conjugation: Unconjugated
In stock
Item Number
Ab110790
Grouped product items
SKU Size
Availability
 Price Qty
Ab110790-10μg
10μg
10
$29.90
Ab110790-50μg
50μg
4
$69.90
Ab110790-100μg
100μg
2
$99.90
Ab110790-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$699.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (PS/2); Rat anti Mouse/Human Integrin alpha 4/CD49D Antibody; Flow, in vivo VLA-4 neutralization, in vitro VLA-4 neutralization; Unconjugated

View related series
Click to view target information: ITGA4
Accession#: Q00651 (2) Accession#:P13612 (6) CD49D (4) Flow Cytometry (1158) Gene ID: 16401 (2) Gene ID:3676 (6) Integrin alpha 4 (4) ITGA4 (7)

Basic Description

Product Name Integrin alpha 4/CD49D Rat mAb - Primary antibody, specific to Integrin alpha 4/CD49D, Rat IgG2b
Synonyms CD49D | 269C wild type | CD49 antigen-like family member D | CD49d antigen | CD49d | CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor | IA4 | Integrin alpha 4 | integrin alpha-4 subunit | integrin alpha-4 | Integrin alpha-IV | integrin, alpha 4 (anti
Specifications & Purity Carrier Free, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Rat
Specificity Integrin alpha 4/CD49D
Immunogen Mouse P815 mast cells
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Rat anti Mouse/Human Integrin alpha 4/CD49D Antibody, Monoclonal (PS/2), could be used for Flow, in vivo VLA-4 neutralization, in vitro VLA-4 neutralization and so on.
Application:
Flow: Use at an assay dependent concentration.
in vivo VLA-4 neutralization: Use at an assay dependent concentration.
in vitro VLA-4 neutralization: Use at an assay dependent concentration.
Protein Function
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Product Properties

Isotype Rat IgG2b
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

ITGA4 Tclin Integrin alpha-4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGA4 Tclin Integrin alpha-4 (295 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Integrin alpha 4/CD49D Rat mAb (Ab110790) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling Integrin alpha 4/CD49D with Integrin alpha 4/CD49D Rat mAb (Ab110790) conjugated with biotin (right panel) at 0.5 μg/mL for 1 hour at 4°C, compared with Rat IgG Isotype Control Antibody (Biotin) (Ab180310) (left panel) and detected with SA-PE (rp156150).

Integrin alpha 4/CD49D Rat mAb (Ab110790) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling Integrin alpha 4/CD49D (red) with Integrin alpha 4/CD49D Rat mAb (Ab110790) conjugated with biotin at 0.5 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Rat IgG Isotype Control Antibody (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.

Application

Application Dilution info
Flow Cytometry

Use at an assay dependent concentration.
in vivo VLA-4 neutralization

Use at an assay dependent concentration.
in vitro VLA-4 neutralization

Use at an assay dependent concentration.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0607436 Certificate of Analysis Jun 26, 2024 Ab110790
ZJ24F0607435 Certificate of Analysis Jun 26, 2024 Ab110790
ZJ24F0607434 Certificate of Analysis Jun 26, 2024 Ab110790

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