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Eculizumab (anti-Complement C5) - Primary antibody, specific to C5, >95%, high purity, Human IgG2+Human IgG4, INHIBITOR of Complement C5 inhibitor, INHIBITOR of Complement C5 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG2+Human IgG4
  • Conjugation: Unconjugated
In stock
Item Number
Ab170870
Grouped product items
SKU Size
Availability
Price Qty
Ab170870-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$99.90
Ab170870-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$477.90
Ab170870-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,437.90
Ab170870-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,277.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2+Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Eculizumab (anti-Complement C5) - Primary antibody, specific to C5, >95%, high purity, Human IgG2+Human IgG4, INHIBITOR of Complement C5 inhibitor
Synonyms Anaphylatoxin C5a analog antibody | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody | C5 antibody | C5a anaphylatoxin antibody | C5a antibody | C5b antibody | CO5_HUMAN antibody | Complement C5 alpha'' chain antibody | Complemen
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity C5
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Complement C5 inhibitor
Product Description

Eculizumab (anti-Complement C5) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab (anti-Complement C5) inhibits the cleavage of C5 into C5a and C5b and hence inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab (anti-Complement C5) has the potential for haemolysis research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Peptides
Direct Parent Dipeptides
Alternative Parents Leucine and derivatives  N-carbamoyl-alpha amino acids and derivatives  N-acyl-alpha amino acids  Tryptamines and derivatives  Alpha amino acid amides  Indolecarboxylic acids  3-alkylindoles  Piperidinecarboxamides  Pyrrole carboxylic acids and derivatives  Medium-chain fatty acids  Amino fatty acids  Aralkylamines  Branched fatty acids  Heterocyclic fatty acids  Benzenoids  Substituted pyrroles  N-substituted carboxylic acid imides  N-acyl amines  Heteroaromatic compounds  Dicarboximides  Ureas  Amino acids  Carboxylic acids  Azacyclic compounds  Monocarboxylic acids and derivatives  Organic oxides  Organopnictogen compounds  Hydrocarbon derivatives  Carbonyl compounds  Monoalkylamines  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Alpha-dipeptide - Leucine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-carbamoyl-alpha-amino acid or derivatives - Alpha-amino acid amide - Indolecarboxylic acid - Indolecarboxylic acid derivative - Triptan - Alpha-amino acid or derivatives - 3-alkylindole - Indole - Indole or derivatives - 1-piperidinecarboxamide - Piperidinecarboxamide - Medium-chain fatty acid - Pyrrole-1-carboxylic acid or derivatives - Heterocyclic fatty acid - Branched fatty acid - Aralkylamine - Amino fatty acid - N-acyl-amine - Carboxylic acid imide, n-substituted - Fatty acyl - Fatty acid - Benzenoid - Piperidine - Substituted pyrrole - Dicarboximide - Carboxylic acid imide - Heteroaromatic compound - Pyrrole - Urea - Amino acid or derivatives - Carbonic acid derivative - Amino acid - Organoheterocyclic compound - Carboxylic acid - Azacycle - Monocarboxylic acid or derivatives - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Amine - Primary aliphatic amine - Hydrocarbon derivative - Primary amine - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
External Descriptors Not available

Product Properties

Isotype Human IgG2+Human IgG4
Light Chain Type kappa
SDS-PAGE 26.1 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 165.6 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 219685-50-4

Associated Targets(Human)

C5 Tclin Complement C5 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Eculizumab (anti-Complement C5) (Ab170870) - SEC
The purity of Eculizumab (anti-Complement C5) (Ab170870) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1001464 Certificate of Analysis Nov 01, 2023 Ab170870
ZJ23F1001463 Certificate of Analysis Nov 01, 2023 Ab170870

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