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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab170870-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$99.90
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Ab170870-1mg
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1mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$477.90
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Ab170870-5mg
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5mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$1,437.90
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Ab170870-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,277.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2+Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Eculizumab (anti-Complement C5) - Primary antibody, specific to C5, >95%, high purity, Human IgG2+Human IgG4, INHIBITOR of Complement C5 inhibitor |
|---|---|
| Synonyms | Anaphylatoxin C5a analog antibody | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody | C5 antibody | C5a anaphylatoxin antibody | C5a antibody | C5b antibody | CO5_HUMAN antibody | Complement C5 alpha'' chain antibody | Complemen |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | C5 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Complement C5 inhibitor |
| Product Description |
Eculizumab (anti-Complement C5) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab (anti-Complement C5) inhibits the cleavage of C5 into C5a and C5b and hence inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab (anti-Complement C5) has the potential for haemolysis research. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Peptides |
| Direct Parent | Dipeptides |
| Alternative Parents | Leucine and derivatives N-carbamoyl-alpha amino acids and derivatives N-acyl-alpha amino acids Tryptamines and derivatives Alpha amino acid amides Indolecarboxylic acids 3-alkylindoles Piperidinecarboxamides Pyrrole carboxylic acids and derivatives Medium-chain fatty acids Amino fatty acids Aralkylamines Branched fatty acids Heterocyclic fatty acids Benzenoids Substituted pyrroles N-substituted carboxylic acid imides N-acyl amines Heteroaromatic compounds Dicarboximides Ureas Amino acids Carboxylic acids Azacyclic compounds Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Hydrocarbon derivatives Carbonyl compounds Monoalkylamines |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Alpha-dipeptide - Leucine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-carbamoyl-alpha-amino acid or derivatives - Alpha-amino acid amide - Indolecarboxylic acid - Indolecarboxylic acid derivative - Triptan - Alpha-amino acid or derivatives - 3-alkylindole - Indole - Indole or derivatives - 1-piperidinecarboxamide - Piperidinecarboxamide - Medium-chain fatty acid - Pyrrole-1-carboxylic acid or derivatives - Heterocyclic fatty acid - Branched fatty acid - Aralkylamine - Amino fatty acid - N-acyl-amine - Carboxylic acid imide, n-substituted - Fatty acyl - Fatty acid - Benzenoid - Piperidine - Substituted pyrrole - Dicarboximide - Carboxylic acid imide - Heteroaromatic compound - Pyrrole - Urea - Amino acid or derivatives - Carbonic acid derivative - Amino acid - Organoheterocyclic compound - Carboxylic acid - Azacycle - Monocarboxylic acid or derivatives - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Carbonyl group - Amine - Primary aliphatic amine - Hydrocarbon derivative - Primary amine - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. |
| External Descriptors | Not available |
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| Isotype | Human IgG2+Human IgG4 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.1 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 165.6 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 219685-50-4 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Eculizumab (anti-Complement C5) (Ab170870) - SEC
The purity of Eculizumab (anti-Complement C5) (Ab170870) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 01, 2023 | Ab170870 | |
| Certificate of Analysis | Nov 01, 2023 | Ab170870 |
Starting at $109.90
Starting at $89.90
Starting at $89.90
Starting at $109.90
Starting at $89.90