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Crovalimab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG1, INHIBITOR of Complement C5 inhibitor, INHIBITOR of Complement C5 inhibitor

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182862
Grouped product items
SKU Size
Availability
 Price Qty
Ab182862-100μg
100μg
10
$89.90
Ab182862-1mg
1mg
4
$419.90
Ab182862-5mg
5mg
1
$1,089.90
Ab182862-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,749.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: C5
Accession#:P01031 (8) C5 (8) Complement C5 (7) Gene ID:727 (8) Hc (2)

Basic Description

Product Name Crovalimab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG1, INHIBITOR of Complement C5 inhibitor
Synonyms Anaphylatoxin C5a analog antibody | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody | C5 antibody | C5a anaphylatoxin antibody | C5a antibody | C5b antibody | CO5_HUMAN antibody | Complement C5 alpha'' chain antibody | Complemen
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity C5
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Complement C5 inhibitor
Product Description

Crovalimab (anti-Complement C5) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab (anti-Complement C5) binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab (anti-Complement C5) can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab (anti-Complement C5) inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab (anti-Complement C5) has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.4 kDa (Light Chain) & 52.7 kDa (Heavy Chain), under reducing conditions; 190.6 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1917321-26-6

Associated Targets(Human)

C5 Tclin Complement C5 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Crovalimab (anti-Complement C5) (Ab182862) - ELISA
Immobilized Human Complement C5 Protein at 2.0 μg/mL can bind Crovalimab (anti-Complement C5) (Ab182862) with the EC50 of 9.58 ng/mL.

Crovalimab (anti-Complement C5) (Ab182862) - SEC
The purity of Crovalimab (anti-Complement C5) (Ab182862) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0606989 Certificate of Analysis Jun 19, 2024 Ab182862
ZJ24F0606988 Certificate of Analysis Jun 19, 2024 Ab182862
ZJ24F0606987 Certificate of Analysis Jun 19, 2024 Ab182862

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