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Cobolimab (anti-TIM-3) - Primary antibody, specific to HAVCR2, Human IgG4SP, INHIBITOR of Hepatitis A virus cellular receptor 2 inhibitor, INHIBITOR of Hepatitis A virus cellular receptor 2 inhibitor

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab182847
Grouped product items
SKU Size
Availability
 Price Qty
Ab182847-100μg
100μg
10
$69.90
Ab182847-1mg
1mg
4
$349.90
Ab182847-5mg
5mg
1
$899.90
Ab182847-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,439.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: HAVCR2
Accession#:Q8TDQ0 (10) CD366 (9) Gene ID:84868 (10) HAVCR2 (11) TIM-3 (7)

Basic Description

Product Name Cobolimab (anti-TIM-3) - Primary antibody, specific to HAVCR2, Human IgG4SP, INHIBITOR of Hepatitis A virus cellular receptor 2 inhibitor
Synonyms CD366 antibody | FLJ14428 antibody | HAVcr-2 antibody | Havcr2 antibody | HAVR2_HUMAN antibody | Hepatitis A virus cellular receptor 2 antibody | Kidney injury molecule 3 antibody | KIM 3 antibody | KIM3 antibody | T cell immunoglobulin and mucin domain c
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity HAVCR2
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Hepatitis A virus cellular receptor 2 inhibitor
Product Description

Cobolimab (anti-TIM-3) is an anti-TIM-3 monoclonal antibody. Cobolimab (anti-TIM-3) mediates the internalization of TIM3 with an IC50 value of 0.4464 nM. Cobolimab (anti-TIM-3) has potential application in solid tumors and non-small cell lung cancer (NSCLC).

Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.7 kDa (Light Chain) & 51.1 kDa (Heavy Chain), under reducing conditions; 197.4 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2022215-65-0

Associated Targets(Human)

HAVCR2 Tchem Hepatitis A virus cellular receptor 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Cobolimab (anti-TIM-3) (Ab182847) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling TIM-3 with Cobolimab (anti-TIM-3) (Ab182847) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Cobolimab (anti-TIM-3) (Ab182847) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling TIM-3 (red) with Cobolimab (anti-TIM-3) (Ab182847) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Cobolimab (anti-TIM-3) (Ab182847) - SEC
The purity of Cobolimab (anti-TIM-3) (Ab182847) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404834 Certificate of Analysis Apr 24, 2024 Ab182847
ZJ24F0404833 Certificate of Analysis Apr 24, 2024 Ab182847
ZJ24F0404832 Certificate of Analysis Apr 24, 2024 Ab182847

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