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Surzebiclimab (anti-TIM-3) - Primary antibody, specific to HAVCR2, >95% (SDS-PAGE&SEC), high purity, Human IgG1

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182869
Grouped product items
SKU Size
Availability
 Price Qty
Ab182869-100μg
100μg
10
$99.90
Ab182869-1mg
1mg
4
$489.90
Ab182869-5mg
5mg
1
$1,279.90
Ab182869-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,049.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: HAVCR2
Accession#:Q8TDQ0 (10) CD366 (9) Gene ID:84868 (10) HAVCR2 (11) TIM-3 (7)

Basic Description

Product Name Surzebiclimab (anti-TIM-3) - Primary antibody, specific to HAVCR2, >95% (SDS-PAGE&SEC), high purity, Human IgG1
Synonyms CD366 antibody | FLJ14428 antibody | HAVcr-2 antibody | Havcr2 antibody | HAVR2_HUMAN antibody | Hepatitis A virus cellular receptor 2 antibody | Kidney injury molecule 3 antibody | KIM 3 antibody | KIM3 antibody | T cell immunoglobulin and mucin domain c
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity HAVCR2
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Product Description

Surzebiclimab (anti-TIM-3) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab (anti-TIM-3) binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab (anti-TIM-3) can be used in research of cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.2 kDa (Light Chain) & 50.7 kDa (Heavy Chain), under reducing conditions; 204.3 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95% (SDS-PAGE&SEC)
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2342597-90-2

Associated Targets(Human)

HAVCR2 Tchem Hepatitis A virus cellular receptor 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Surzebiclimab (anti-TIM-3) (Ab182869) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling TIM-3 with Surzebiclimab (anti-TIM-3) (Ab182869) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Surzebiclimab (anti-TIM-3) (Ab182869) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling TIM-3 (red) with Surzebiclimab (anti-TIM-3) (Ab182869) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Surzebiclimab (anti-TIM-3) (Ab182869) - ELISA
Immobilized Recombinant Human TIM-3 Protein (rp176703) at 1.0 μg/mL can bind Surzebiclimab (anti-TIM-3) (Ab182869) with the EC50 of 15.3 ng/mL.

Surzebiclimab (anti-TIM-3) (Ab182869) - SEC
The purity of Surzebiclimab (anti-TIM-3) (Ab182869) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0506002 Certificate of Analysis May 23, 2024 Ab182869
ZJ24F0506001 Certificate of Analysis May 23, 2024 Ab182869
ZJ24F0506000 Certificate of Analysis May 23, 2024 Ab182869

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