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C 176 - ≥97%(HPLC), high purity , CAS No.314054-00-7

COA COA
    Grade & Purity:
  • ≥97%(HPLC)
In stock
Item Number
C288157
Grouped product items
SKU Size
Availability
 Price Qty
C288157-5mg
5mg
3
$48.90
C288157-10mg
10mg
3
$88.90
C288157-50mg
50mg
3
$167.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mSTING antagonist

View related series
Immunology/Inflammation (1929) STING (52)

Basic Description

Synonyms C-176, Sting inhibitor 1, Sting inhibitor C-176, N-(4-Iodophenyl)-5-nitro-2-furancarboxamide, N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide, C176
Specifications & Purity ≥97%(HPLC)
Biochemical and Physiological Mechanisms mSTING antagonist. Covalently binds Cys91 of mouse but not human STING. Blocks activation-induced palmitoylation of STING and formation of STING clusters. ReducesCMA-induced increase in serum IFNsin vivoand suppresses systemic inflammation in a mouse infl
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Anilides
Intermediate Tree Nodes Aromatic anilides - Furanilides
Direct Parent 2-furanilides
Alternative Parents 2-heteroaryl carboxamides  Furoic acid and derivatives  Nitroaromatic compounds  Nitrofurans  Iodobenzenes  Aryl iodides  Heteroaromatic compounds  Secondary carboxylic acid amides  Propargyl-type 1,3-dipolar organic compounds  Oxacyclic compounds  Organic oxoazanium compounds  Organic oxides  Organic zwitterions  Hydrocarbon derivatives  Organoiodides  Organonitrogen compounds  Organooxygen compounds  Organopnictogen compounds  
Molecular Framework Aromatic heteromonocyclic compounds
Substituents 2-furanilide - 2-heteroaryl carboxamide - 2-nitrofuran - Furoic acid or derivatives - Nitroaromatic compound - Iodobenzene - Halobenzene - Aryl halide - Aryl iodide - Heteroaromatic compound - Furan - Organic nitro compound - Carboxamide group - Secondary carboxylic acid amide - C-nitro compound - Oxacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Organic oxoazanium - Carboxylic acid derivative - Organic nitrogen compound - Organohalogen compound - Organoiodide - Organonitrogen compound - Organooxygen compound - Organic zwitterion - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
Description This compound belongs to the class of organic compounds known as 2-furanilides. These are aromatic heterocyclic compounds contaning a furan ring that is substituted at the 2-position with an anilide.
External Descriptors Not available

Associated Targets(Human)

HEK293 (82097 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC1143 (70 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC1806 (544 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCC38 (164 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK-293T (167025 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

RAW264.7 (28094 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504760389
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504760389
IUPAC Name N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
INCHI InChI=1S/C11H7IN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15)
InChIKey JBIKQXOZLBLMKI-UHFFFAOYSA-N
Smiles C1=CC(=CC=C1NC(=O)C2=CC=C(O2)[N+](=O)[O-])I
Isomeric SMILES C1=CC(=CC=C1NC(=O)C2=CC=C(O2)[N+](=O)[O-])I
Molecular Weight 358.09
Reaxy-Rn 10548659
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10548659&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
F2509115 Certificate of Analysis Jun 17, 2025 C288157
C2209406 Certificate of Analysis Dec 19, 2024 C288157
C2209418 Certificate of Analysis Dec 19, 2024 C288157
C2209417 Certificate of Analysis Dec 12, 2024 C288157
E2415043 Certificate of Analysis Dec 29, 2021 C288157

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 35.81, Max Conc. mM: 100
Molecular Weight 358.090 g/mol
XLogP3 3.000
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 2
Exact Mass 357.945 Da
Monoisotopic Mass 357.945 Da
Topological Polar Surface Area 88.100 Ų
Heavy Atom Count 18
Formal Charge 0
Complexity 325.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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