Potent protein kinase C activator with high binding affinity (K i = 1.35 nM). A macrolide lactone. Potently downregulates PKCα, PKCδ and PKCε compared to PMA . Range of biological activities. Active in vivo .
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Product Explanation Bryostatin 1 is a natural macrolide compound isolated from Bugula neritina, a moss worm, and an effective PKC regulator of central nervous system (CNS) permeability. Bryostatin 1 binds to the C1 domain of isolated Munc13-1 and the full-length Munc13-1 protein with Ki values of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has characteristics of anti-cancer, anti-inflammatory, neuroprotective, and anti HIV-1 infection.
This compound belongs to the class of organic compounds known as pentacarboxylic acids and derivatives. These are carboxylic acids containing exactly five carboxyl groups.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
E2428067