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BIO-013077-01 - 98%, high purity , CAS No.746667-48-1

COA

Grade & Purity:

≥98%

Cas Number: 746667-48-1
Molecular Weight: 287.32
PubChem CID: 10469294

In stock

Item Number

B650439

Grouped product items
SKU	Size	Availability	Price
B650439-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$90.90
B650439-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$190.90
B650439-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$290.90
B650439-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$580.90
B650439-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90

View related series

TGF-beta/Smad (303) TGF-β Receptor (70)

Basic Description

Synonyms	HY-118810 \| BIO-013077-01 \| SCHEMBL4008166 \| BCP30129 \| MS-24106 \| AKOS016013184 \| 6-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoxaline \| 6-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline \| ZB0034 \| EX-A3237 \| AJ-97166;AJ97166;AJ 97166;6-[5-(6-me
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	BIO-013077-01 is a pyrazole TGF-β inhibitor.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	BIO-013077-01 is a pyrazole TGF-β inhibitor. In Vitro A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazanaphthalenes
    - Subclass Benzodiazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazanaphthalenes
Subclass	Benzodiazines
Intermediate Tree Nodes	Not available
Direct Parent	Quinoxalines
Alternative Parents	Methylpyridines Pyrazines Benzenoids Pyrazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinoxaline - Methylpyridine - Benzenoid - Pyridine - Pyrazine - Heteroaromatic compound - Pyrazole - Azole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinoxalines. These are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	6-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline
INCHI	InChI=1S/C17H13N5/c1-11-3-2-4-15(21-11)17-13(10-20-22-17)12-5-6-14-16(9-12)19-8-7-18-14/h2-10H,1H3,(H,20,22)
InChIKey	VXJLYXCHOKEODY-UHFFFAOYSA-N
Smiles	CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC4=NC=CN=C4C=C3
Isomeric SMILES	CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC4=NC=CN=C4C=C3
Alternate CAS	746667-48-1
PubChem CID	10469294
Molecular Weight	287.32

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (348.04 mM; Need ultrasonic)
Molecular Weight	287.320 g/mol
XLogP3	2.200
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	287.117 Da
Monoisotopic Mass	287.117 Da
Topological Polar Surface Area	67.400 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	376.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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