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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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B286959-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$76.90
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B286959-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$129.90
|
|
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B286959-25mg
|
25mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$249.90
|
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B286959-50mg
|
50mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$429.90
|
|
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B286959-100mg
|
100mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$669.90
|
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Potent and selective NHE1 inhibitor
| Synonyms | BIX Hydrochloride | BIX HCl | Benzamide, 4-(1-acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)-, hydrochloride |
|---|---|
| Specifications & Purity | ≥95% |
| Biochemical and Physiological Mechanisms | Potent and selective NHE1 inhibitor (IC50= 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart modelex vivo. Preventsphenylephrine-induced cardiomyocyte hypertrophyin vitro, and atte |
| Storage Temp | Store at 2-8°C,Desiccated |
| Shipped In |
Wet ice This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury. |
| IUPAC Name | 4-(1-acetylpiperidin-4-yl)-N-(diaminomethylidene)-3-(trifluoromethyl)benzamide;hydrochloride |
|---|---|
| INCHI | InChI=1S/C16H19F3N4O2.ClH/c1-9(24)23-6-4-10(5-7-23)12-3-2-11(14(25)22-15(20)21)8-13(12)16(17,18)19;/h2-3,8,10H,4-7H2,1H3,(H4,20,21,22,25);1H |
| InChIKey | SLSZLEROFKLICF-UHFFFAOYSA-N |
| Smiles | CC(=O)N1CCC(CC1)C2=C(C=C(C=C2)C(=O)N=C(N)N)C(F)(F)F.Cl |
| Alternate CAS | 1204329-34-9 |
| PubChem CID | 121513866 |
| Molecular Weight | 356.34(free) |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jul 23, 2024 | B286959 | |
| Certificate of Analysis | Jul 23, 2024 | B286959 | |
| Certificate of Analysis | Jul 23, 2024 | B286959 | |
| Certificate of Analysis | Jul 23, 2024 | B286959 | |
| Certificate of Analysis | Jul 23, 2024 | B286959 | |
| Certificate of Analysis | Jul 23, 2024 | B286959 | |
| Certificate of Analysis | Jul 23, 2024 | B286959 | |
| Certificate of Analysis | Jul 23, 2024 | B286959 | |
| Certificate of Analysis | Jul 23, 2024 | B286959 |
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 19.64, Max Conc. mM: 50 |
|---|---|
| Sensitivity | Moisture sensitive |
| Molecular Weight | 392.800 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 392.123 Da |
| Monoisotopic Mass | 392.123 Da |
| Topological Polar Surface Area | 102.000 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 538.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
Starting at $1,334.90
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