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BI-9627 hydrochloride - ≥95%, high purity , CAS No.1422252-46-7

    Grade & Purity:
  • ≥95%
In stock
Item Number
B286959
Grouped product items
SKU Size
Availability
Price Qty
B286959-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$76.90
B286959-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$129.90
B286959-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$249.90
B286959-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$429.90
B286959-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$669.90

Potent and selective NHE1 inhibitor

Basic Description

Synonyms BIX Hydrochloride | BIX HCl | Benzamide, 4-(1-acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)-, hydrochloride
Specifications & Purity ≥95%
Biochemical and Physiological Mechanisms Potent and selective NHE1 inhibitor (IC50= 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart modelex vivo. Preventsphenylephrine-induced cardiomyocyte hypertrophyin vitro, and atte
Storage Temp Store at 2-8°C,Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

Names and Identifiers

IUPAC Name 4-(1-acetylpiperidin-4-yl)-N-(diaminomethylidene)-3-(trifluoromethyl)benzamide;hydrochloride
INCHI InChI=1S/C16H19F3N4O2.ClH/c1-9(24)23-6-4-10(5-7-23)12-3-2-11(14(25)22-15(20)21)8-13(12)16(17,18)19;/h2-3,8,10H,4-7H2,1H3,(H4,20,21,22,25);1H
InChIKey SLSZLEROFKLICF-UHFFFAOYSA-N
Smiles CC(=O)N1CCC(CC1)C2=C(C=C(C=C2)C(=O)N=C(N)N)C(F)(F)F.Cl
Alternate CAS 1204329-34-9
PubChem CID 121513866
Molecular Weight 356.34(free)

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot Number Certificate Type Date Item
K2420285 Certificate of Analysis Jul 23, 2024 B286959
K2420286 Certificate of Analysis Jul 23, 2024 B286959
K2420290 Certificate of Analysis Jul 23, 2024 B286959
K2420293 Certificate of Analysis Jul 23, 2024 B286959
K2420438 Certificate of Analysis Jul 23, 2024 B286959
K2420439 Certificate of Analysis Jul 23, 2024 B286959
K2420432 Certificate of Analysis Jul 23, 2024 B286959
K2420444 Certificate of Analysis Jul 23, 2024 B286959
K2420445 Certificate of Analysis Jul 23, 2024 B286959

Chemical and Physical Properties

Solubility Solvent:DMSO, Max Conc. mg/mL: 19.64, Max Conc. mM: 50
Sensitivity Moisture sensitive
Molecular Weight 392.800 g/mol
XLogP3
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 2
Exact Mass 392.123 Da
Monoisotopic Mass 392.123 Da
Topological Polar Surface Area 102.000 Ų
Heavy Atom Count 26
Formal Charge 0
Complexity 538.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

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