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AZD8848 - 98%, high purity , CAS No.866269-28-5

COA

Grade & Purity:

≥98%

Cas Number: 866269-28-5
Molecular Weight: 569.70
EC Number: 642-434-9
PubChem CID: 11592228

In stock

Item Number

A651185

Grouped product items
SKU	Size	Availability	Price
A651185-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$450.90
A651185-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90
A651185-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,650.90
A651185-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,550.90
A651185-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,800.90

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Immunology/Inflammation (1929) Toll-like Receptor (TLR) (148)

Basic Description

Synonyms	methyl 2-(3-(((3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl)(3-morpholinopropyl)amino)methyl)phenyl)acetate \| Benzeneacetic acid, 3-(((3-(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)propyl)(3-(4-morpholinyl)propyl)amino)methyl)-, methyl
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	AZD8848 is a selective toll-like receptor 7 (TLR7) anteagent agonist which is developed for the research of asthma and allergic rhinitis.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	AZD8848 is a selective toll-like receptor 7 (TLR7) anteagent agonist which is developed for the research of asthma and allergic rhinitis In Vitro AZD8848 shows good activity against TLR7, with cellular pEC 50 s of 7.0 and 6.6 for human TLR7 and rat TLR7, respectively. AZD8848 has an EC 50 of 4 nM in the induction of IFNα from human PBMCs and an IC 50 of 0.2-1.0 nM for the inhibition of IL-5, irrespective of whether the T cells have been polyclonally stimulated with PHA or via antigen presentation. AZD8848 is a potent, selective TLR7 agonist antedrug able to inhibit Th2 responses in vitro. AZD8848 has no activity against human TLR8 or against any of the other human TLRs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AZD8848 (0.1-1 mg/kg; intratracheal) has a good pharmacokinetics in the Brown Norway rat . AZD8848 (0.3 mg/kg; Intratracheal) suppresses the ovalbumin (OVA) challenge in the rat allergy model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Brown Norway rat allergy model Dosage: 0.1 mg/kg, 1 mg/kg Administration: Intratracheal (24 hours prior to and 24 hours after the OVA challenge) Result: Suppressed OVA challenge in a dose-dependent manner. Animal Model: Brown Norway rat Dosage: 0.3 mg/kg (Pharmacokinetic Analysis) Administration: Intratracheal Result: Has a very short half-life (0.2 min) in rat blood and declined slowly after this point and levels above 1000 nmol/kg were maintained for over 5 hours. Form:Solid IC50& Target:TLR7

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Imidazopyrimidines
    - Subclass Purines and purine derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Imidazopyrimidines
Subclass	Purines and purine derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Purinones
Alternative Parents	6-aminopurines Phenylmethylamines Benzylamines Alkyl aryl ethers Aminopyrimidines and derivatives Aralkylamines N-substituted imidazoles Morpholines Imidolactams Methyl esters Heteroaromatic compounds Ureas Trialkylamines Amino acids and derivatives Oxacyclic compounds Monocarboxylic acids and derivatives Azacyclic compounds Dialkyl ethers Hydrocarbon derivatives Organic oxides Primary amines Carbonyl compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	6-aminopurine - Purinone - Benzylamine - Phenylmethylamine - Alkyl aryl ether - Aminopyrimidine - Aralkylamine - Morpholine - N-substituted imidazole - Monocyclic benzene moiety - Oxazinane - Pyrimidine - Benzenoid - Imidolactam - Imidazole - Azole - Heteroaromatic compound - Methyl ester - Amino acid or derivatives - Carboxylic acid ester - Tertiary amine - Tertiary aliphatic amine - Urea - Oxacycle - Ether - Dialkyl ether - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Carbonyl group - Organonitrogen compound - Organooxygen compound - Primary amine - Hydrocarbon derivative - Organic oxide - Amine - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as purinones. These are purines in which the purine moiety bears a C=O group. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	methyl 2-[3-[[3-(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)propyl-(3-morpholin-4-ylpropyl)amino]methyl]phenyl]acetate
INCHI	InChI=1S/C29H43N7O5/c1-3-4-16-41-28-32-26(30)25-27(33-28)36(29(38)31-25)13-7-12-35(11-6-10-34-14-17-40-18-15-34)21-23-9-5-8-22(19-23)20-24(37)39-2/h5,8-9,19H,3-4,6-7,10-18,20-21H2,1-2H3,(H,31,38)(H2,30,32,33)
InChIKey	FEFIBEHSXLKJGI-UHFFFAOYSA-N
Smiles	CCCCOC1=NC(=C2C(=N1)N(C(=O)N2)CCCN(CCCN3CCOCC3)CC4=CC=CC(=C4)CC(=O)OC)N
Isomeric SMILES	CCCCOC1=NC(=C2C(=N1)N(C(=O)N2)CCCN(CCCN3CCOCC3)CC4=CC=CC(=C4)CC(=O)OC)N
Alternate CAS	866269-28-5,1310826-85-7
PubChem CID	11592228
MeSH Entry Terms	AZD8848
Molecular Weight	569.70

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 25 mg/mL (43.88 mM; ultrasonic and warming and heat to 60°C)
Molecular Weight	569.700 g/mol
XLogP3	2.300
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	17
Exact Mass	569.333 Da
Monoisotopic Mass	569.333 Da
Topological Polar Surface Area	135.000 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	802.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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