Skip to the beginning of the images gallery

AZD1386 , Vanilloid receptor antagonist, CAS No.946080-23-5, Vanilloid receptor antagonist

COA

Grade & Purity:

Moligand™

Cas Number: 946080-23-5
Molecular Weight: 423.8
PubChem CID: 24752296

In stock

Item Number

A607856

Grouped product items
SKU	Size	Availability	Price	Qty
A607856-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607856-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90

View related series

TRPV1 Inhibitor (1)

Basic Description

Synonyms	CID 24752296 \| KB-270807 \| GTPL7820 \| 5/'-chloro-7/'-methyl-1/'-[[3-(trifluoromethyl)phenyl]methyl]spiro[imidazolidine-5,3/'-indole]-2,2/',4-trione \| DXDVSYALLVVBOV-UHFFFAOYSA-N \| AZD 1386 \| SCHEMBL4257077 \| Q27074708 \| 5'-chloro-7'-methyl-1'-[[3-(trifluo
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST, INHIBITOR
Mechanism of action	Vanilloid receptor antagonist

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azolidines
    - Subclass Imidazolidines
      - Level5 Imidazolidinones
        Level6 Imidazolidinediones
        Level7 Hydantoins

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azolidines
Subclass	Imidazolidines
Intermediate Tree Nodes	Imidazolidinones - Imidazolidinediones
Direct Parent	Hydantoins
Alternative Parents	Trifluoromethylbenzenes Alpha amino acids and derivatives Indoles and derivatives 5-monosubstituted hydantoins N-acyl ureas Aryl chlorides Tertiary carboxylic acid amides Dicarboximides Lactams Azacyclic compounds Hydrocarbon derivatives Organochlorides Carbonyl compounds Organopnictogen compounds Organofluorides Organonitrogen compounds Alkyl fluorides Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Hydantoin - Alpha-amino acid or derivatives - Trifluoromethylbenzene - Indole or derivatives - 5-monosubstituted hydantoin - Ureide - N-acyl urea - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Dicarboximide - Tertiary carboxylic acid amide - Carboxamide group - Urea - Lactam - Carbonic acid derivative - Azacycle - Carboxylic acid derivative - Organooxygen compound - Organic nitrogen compound - Alkyl halide - Hydrocarbon derivative - Alkyl fluoride - Carbonyl group - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organohalogen compound - Organochloride - Organofluoride - Organonitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as hydantoins. These are heterocyclic compounds containing an imidazolidine substituted by ketone group at positions 2 and 4.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 (1 Activities)

Discover Target: TRPV1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5'-chloro-7'-methyl-1'-[[3-(trifluoromethyl)phenyl]methyl]spiro[imidazolidine-5,3'-indole]-2,2',4-trione
INCHI	InChI=1S/C19H13ClF3N3O3/c1-9-5-12(20)7-13-14(9)26(16(28)18(13)15(27)24-17(29)25-18)8-10-3-2-4-11(6-10)19(21,22)23/h2-7H,8H2,1H3,(H2,24,25,27,29)
InChIKey	DXDVSYALLVVBOV-UHFFFAOYSA-N
Smiles	O=C1NC(=O)C2(N1)c1cc(Cl)cc(c1N(C2=O)Cc1cccc(c1)C(F)(F)F)C
Isomeric SMILES	CC1=CC(=CC2=C1N(C(=O)C23C(=O)NC(=O)N3)CC4=CC(=CC=C4)C(F)(F)F)Cl
PubChem CID	24752296
Molecular Weight	423.8

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration