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Artemisone - ≥98.0%, high purity , CAS No.255730-18-8

COA

Grade & Purity:

≥98%

Cas Number: 255730-18-8
Molecular Weight: 401.52
PubChem CID: 11531457

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Item Number

A650926

Grouped product items
SKU	Size	Availability	Price
A650926-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$166.90
A650926-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
A650926-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90
A650926-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,650.90
A650926-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,650.90

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Anti-infection (2803) CMV (33) Parasite (997) Virus (1811)

Basic Description

Synonyms	artemisone \| 4-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-Trimethyldecahydro-12H-3,12-epoxypyrano(4,3-j)(1,2)benzodioxepin-10-yl)thiomorpholine-1,1-dione \| BAY 44-9585 \| 4-[(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Artemisone (Artemifone) is a potent and semi-synthetic antimalarial , inhibits P. falciparum strains, with a mean IC 50 of 0.83 nM. Artemisone is also a potent inhibitor of human CMV.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Artemisone (Artemifone) is a potent and semi-synthetic antimalarial , inhibits P. falciparum strains, with a mean IC 50 of 0.83 nM Artemisone is also a potent inhibitor of human CMV . In Vitro Artemisone inhibits 3D7 and K1 P. falciparum , with IC 50 s of 0.88±0.59 and 1.23±0.64 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Artemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED 50 of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration . Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Plasmodium

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Prenol lipids
    - Subclass Sesquiterpenoids

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Prenol lipids
Subclass	Sesquiterpenoids
Intermediate Tree Nodes	Not available
Direct Parent	Artemisinins
Alternative Parents	Oxepanes Trioxanes Thiomorpholines Oxanes Sulfones Hemiaminals Dialkyl peroxides Oxacyclic compounds Azacyclic compounds Acetals Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Artemisinin skeleton - Oxepane - Oxane - 1,2,4-trioxane - 1,4-thiazinane - Sulfone - Hemiaminal - Dialkyl peroxide - Acetal - Oxacycle - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aliphatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as artemisinins. These are sesquiterpenoids originally isolated from the herb Artemisia annua. Their structure is based on artemisinin, a tetracyclic compound that contains a 1,2-dioxepane fused to an octahydrobenzopyran moiety. The internal peroxide bridge is believed to be a key to the mode of action of artemisinins.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

Homo sapiens (32628 Activities)

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HFF (3142 Activities)

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Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

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Leishmania donovani (89745 Activities)

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Trypanosoma cruzi (99888 Activities)

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Toxoplasma gondii (4585 Activities)

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Plasmodium berghei (192651 Activities)

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Trypanosoma brucei rhodesiense (7991 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-[(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]-1,4-thiazinane 1,1-dioxide
INCHI	InChI=1S/C19H31NO6S/c1-12-4-5-15-13(2)16(20-8-10-27(21,22)11-9-20)23-17-19(15)14(12)6-7-18(3,24-17)25-26-19/h12-17H,4-11H2,1-3H3/t12-,13-,14+,15+,16-,17-,18-,19-/m1/s1
InChIKey	FDMUNKXWYMSZIR-NQWKWHCYSA-N
Smiles	CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)N5CCS(=O)(=O)CC5)C
Isomeric SMILES	C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)N5CCS(=O)(=O)CC5)C
Alternate CAS	255730-18-8
PubChem CID	11531457
MeSH Entry Terms	artemisone;BAY 44-9585
Molecular Weight	401.52

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 130 mg/mL (323.77 mM; Need ultrasonic)
Molecular Weight	401.500 g/mol
XLogP3	2.400
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	401.187 Da
Monoisotopic Mass	401.187 Da
Topological Polar Surface Area	82.700 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	695.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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Artemisone - ≥98.0%, high purity , CAS No.255730-18-8

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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