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APX-115 - 99%, high purity , CAS No.1395946-75-4

COA

Grade & Purity:

≥99%

Cas Number: 1395946-75-4
Molecular Weight: 315.80
PubChem CID: 60172240

In stock

Item Number

A650330

Grouped product items
SKU	Size	Availability	Price
A650330-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$150.90
A650330-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
A650330-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$500.90
A650330-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90

View related series

Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860) NADPH Oxidase (17)

Basic Description

Synonyms	1H-Pyrazol-5-ol, 3-phenyl-4-propyl-1-(2-pyridinyl)-, hydrochloride (1:1) \| HY-120801 \| 1395946-75-4 \| Apx 115 \| Q99G5ZE5U5 \| APX 115 [WHO-DD] \| Isuzinaxib hydrochloride \| SCHEMBL15610231 \| UNII-Q99G5ZE5U5 \| 5-phenyl-4-propyl-2-pyridin-2-yl-1H-pyrazol-3-on
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1 , Nox2 and Nox4 , respectively. APX-115 effectively prevents kidney injury.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K i values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1 , Nox2 and Nox4 , respectively. APX-115 effectively prevents kidney injury In Vitro APX-115 (5?μM; 60?min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression in the mouse podocyte cell line. ?\nIn the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo APX-115 (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice. ?\nAPX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Six-week-old male diabetic db/db mice (C57BLKS/J- lepr db /lepr db )Dosage: 60 mg/kg Administration: Oral gavage; per day; for 12 weeks Result: Significantly improved insulin resistance in diabetic mice. Form:Solid IC50& Target:NOX1 NOX2 NOX4

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Pyrazolylpyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Pyrazolylpyridines
Intermediate Tree Nodes	Not available
Direct Parent	Pyrazolylpyridines
Alternative Parents	Methylpyridines Benzene and substituted derivatives Vinylogous amides Pyrazolines Pyrazoles Heteroaromatic compounds Lactams Propargyl-type 1,3-dipolar organic compounds Carboxylic acids and derivatives Azacyclic compounds Aldimines Organopnictogen compounds Organooxygen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	2-pyrazolylpyridine - Methylpyridine - Benzenoid - Monocyclic benzene moiety - Heteroaromatic compound - Vinylogous amide - Pyrazoline - Pyrazole - Azole - Lactam - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboxylic acid derivative - Aldimine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Hydrochloride - Organooxygen compound - Organonitrogen compound - Imine - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as pyrazolylpyridines. These are compounds containing a pyrazolylpyridine skeleton, which consists of a pyrazole linked (not fused) to a pyridine by a bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	5-phenyl-4-propyl-2-pyridin-2-yl-1H-pyrazol-3-one;hydrochloride
INCHI	InChI=1S/C17H17N3O.ClH/c1-2-8-14-16(13-9-4-3-5-10-13)19-20(17(14)21)15-11-6-7-12-18-15;/h3-7,9-12,19H,2,8H2,1H3;1H
InChIKey	YEEIHSUMLNXRMI-UHFFFAOYSA-N
Smiles	CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3.Cl
Isomeric SMILES	CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3.Cl
Alternate CAS	1395946-75-4
PubChem CID	60172240
MeSH Entry Terms	3-phenyl-1-(pyridin-2-yl)-4-propyl-1H-5-hydroxypyrazole HCl;3-phenyl-4-propyl-1-(2-pyridinyl)-1H-pyrazol-5-ol;3-phenyl-4-propyl-1-(2-pyridinyl)-1H-pyrazol-5-ol hydrochloride;APX-115;APX-115 free base;Ewha-18278;EWHA-18278 free base;isuzinaxib;isuzinaxib h
Molecular Weight	315.80

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (316.66 mM; Need ultrasonic)
Molecular Weight	315.800 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	315.114 Da
Monoisotopic Mass	315.114 Da
Topological Polar Surface Area	45.200 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	412.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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