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APS-2-79 - ≥98%, high purity , CAS No.2002381-31-7

COA

Grade & Purity:

≥98%

Cas Number: 2002381-31-7
Molecular Weight: 423.89
PubChem CID: 122177134
PubChem SID: 504772964

In stock

Item Number

A275508

Grouped product items
SKU	Size	Availability	Price
A275508-5mg	5mg	3	$91.90
A275508-10mg	10mg	2	$164.90
A275508-25mg	25mg	2	$372.90
A275508-50mg	50mg	1	$670.90
A275508-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$840.90

KSR-dependent MAPK modulator.

View related series

MAPK/ERK Pathway (546) MEK (59)

Basic Description

Synonyms	6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine hydrochloride \| 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-aminehydrochloride
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	APS-2-79 is a stabilizer of the Kinase suppressor of Ras (KSR) inactive state, resulting in inhibition of oncogenic Ras signaling, antagonizing the Ras–MAPK pathway. KSR is a MAPK scaffold that is regulated allosterically by dimerization with RAF. APS-2-7
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.

Names and Identifiers

Pubchem Sid	504772964
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504772964
IUPAC Name	6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine;hydrochloride
INCHI	InChI=1S/C23H21N3O3.ClH/c1-15-11-17(29-16-7-5-4-6-8-16)9-10-19(15)26-23-18-12-21(27-2)22(28-3)13-20(18)24-14-25-23;/h4-14H,1-3H3,(H,24,25,26);1H
InChIKey	LIXKSHWZJNNZHG-UHFFFAOYSA-N
Smiles	CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC.Cl
Molecular Weight	423.89
Reaxy-Rn	33754141
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33754141&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
L2122334	Certificate of Analysis	Oct 20, 2022	A275508
L2122336	Certificate of Analysis	Oct 20, 2022	A275508
L2122335	Certificate of Analysis	Oct 20, 2022	A275508
L2122333	Certificate of Analysis	Oct 20, 2022	A275508
L2122332	Certificate of Analysis	Oct 20, 2022	A275508

Chemical and Physical Properties

Solubility	Soluble in DMSO to 228.83mM and in Ethanol to 75.49 mM
Molecular Weight	423.900 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	423.135 Da
Monoisotopic Mass	423.135 Da
Topological Polar Surface Area	65.500 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	502.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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