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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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A105534-5mg
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5mg |
3
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$9.90
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A105534-25mg
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25mg |
8
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$37.90
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A105534-50mg
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50mg |
3
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$57.90
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A105534-100mg
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100mg |
5
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$102.90
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A105534-250mg
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250mg |
3
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$232.90
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A105534-500mg
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500mg |
3
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$418.90
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A105534-1g
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1g |
3
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$754.90
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Competitive, reversible serine protease inhibitor.
| Product Name | Aprotinin from bovine lung - 3-8 TIU/mg, high purity , CAS No.9087-70-1 |
|---|---|
| Synonyms | Aprotinin from bovine lung | CCG-270718 | APROTININ | Traskolan | Antilysin | J-200086 | Bovine Pancreatic Trypsin Inhibitor | AKOS024457997 | Traskolan | Bovine Pancreatic Trypsin Inhibitor |
| Grade | EnzymoPure™ |
| Product Description |
Aprotinin is a single chain polypeptide (58 amino-acids) crosslinked by three disulfide bridges, showing competitive and reversible inhibiton of proteolytic and esterolytic activity. Aprotinin forms stable complexes and blocks the active sites of serine protease enzymes. Binding is reversible with most aprotinin-protease complexes dissociating at pH >10 or < 3 (optimum pH 5-7); effective concentration is equimolar with protease. Used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones. |
| Specifications & Purity | EnzymoPure™, 3-8 TIU/mg |
| Biochemical and Physiological Mechanisms | Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Ap |
| Action Type | INHIBITOR |
| Mechanism of action | Inhibitor of plasminogen |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic Polymers |
| Class | Polypeptides |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Polypeptides |
| Alternative Parents | Cyclic peptides Phenylalanine and derivatives Pentacarboxylic acids and derivatives Aspartic acid and derivatives N-acyl-alpha amino acids Proline and derivatives Alpha amino acid amides Alanine and derivatives Amphetamines and derivatives Pyrrolidinecarboxamides N-acylpyrrolidines 1-hydroxy-2-unsubstituted benzenoids N-acyl amines Tertiary carboxylic acid amides Secondary alcohols Guanidines Amino acids Organic disulfides Secondary carboxylic acid amides Lactams Primary carboxylic acid amides Sulfenyl compounds Azacyclic compounds Carboximidamides Carboxylic acids Dialkylthioethers Primary alcohols Imines Carbonyl compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Monoalkylamines |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Polypeptide - Cyclic alpha peptide - Phenylalanine or derivatives - Pentacarboxylic acid or derivatives - Aspartic acid or derivatives - N-acyl-alpha amino acid or derivatives - N-acyl-alpha-amino acid - Proline or derivatives - Alpha-amino acid amide - Alanine or derivatives - Amphetamine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Fatty acyl - Benzenoid - N-acyl-amine - Fatty amide - Pyrrolidine - Tertiary carboxylic acid amide - Organic disulfide - Amino acid or derivatives - Primary carboxylic acid amide - Carboxamide group - Amino acid - Secondary alcohol - Secondary carboxylic acid amide - Lactam - Guanidine - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Carboxylic acid - Dialkylthioether - Sulfenyl compound - Carboximidamide - Thioether - Hydrocarbon derivative - Organic oxide - Amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Alcohol - Imine - Primary aliphatic amine - Primary amine - Primary alcohol - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues. |
| External Descriptors | Not available |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Concentration | 3-8 TIU/mg |
|---|---|
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| CAS | 9087-70-1 |
| Unit definition | A trypsin inhibitor unit (TIU) can reduce the activity of two trypsin units by 50%, and one trypsin unit can hydrolyze 1.0 μ mol of N-α- benzoyl -DL- arginine p-nitroaniline per minute at pH 7.8 and 25℃. Another commonly used unit is KIU, and 1 TIU = 1,30 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jul 14, 2025 | A105534 | |
| Certificate of Analysis | Jul 14, 2025 | A105534 | |
| Certificate of Analysis | Jul 14, 2025 | A105534 | |
| Certificate of Analysis | May 09, 2025 | A105534 | |
| Certificate of Analysis | May 09, 2025 | A105534 | |
| Certificate of Analysis | May 09, 2025 | A105534 | |
| Certificate of Analysis | May 09, 2025 | A105534 | |
| Certificate of Analysis | May 09, 2025 | A105534 | |
| Certificate of Analysis | May 09, 2025 | A105534 | |
| Certificate of Analysis | Dec 26, 2024 | A105534 | |
| Certificate of Analysis | Dec 26, 2024 | A105534 | |
| Certificate of Analysis | Dec 26, 2024 | A105534 | |
| Certificate of Analysis | Dec 26, 2024 | A105534 | |
| Certificate of Analysis | Dec 26, 2024 | A105534 | |
| Certificate of Analysis | Aug 08, 2024 | A105534 | |
| Certificate of Analysis | Aug 08, 2024 | A105534 | |
| Certificate of Analysis | Aug 08, 2024 | A105534 | |
| Certificate of Analysis | Aug 08, 2024 | A105534 | |
| Certificate of Analysis | Mar 08, 2024 | A105534 | |
| Certificate of Analysis | Mar 08, 2024 | A105534 | |
| Certificate of Analysis | Mar 08, 2024 | A105534 | |
| Certificate of Analysis | Mar 08, 2024 | A105534 | |
| Certificate of Analysis | Mar 08, 2024 | A105534 | |
| Certificate of Analysis | Mar 08, 2024 | A105534 | |
| Certificate of Analysis | Feb 21, 2024 | A105534 | |
| Certificate of Analysis | Feb 21, 2024 | A105534 | |
| Certificate of Analysis | Nov 13, 2023 | A105534 | |
| Certificate of Analysis | Jul 05, 2023 | A105534 | |
| Certificate of Analysis | Jul 05, 2023 | A105534 | |
| Certificate of Analysis | Jul 05, 2023 | A105534 | |
| Certificate of Analysis | Jul 05, 2023 | A105534 | |
| Certificate of Analysis | Jul 05, 2023 | A105534 | |
| Certificate of Analysis | Jul 05, 2023 | A105534 | |
| Certificate of Analysis | Jul 05, 2023 | A105534 | |
| Certificate of Analysis | Jul 05, 2023 | A105534 | |
| Certificate of Analysis | May 09, 2023 | A105534 | |
| Certificate of Analysis | May 09, 2023 | A105534 | |
| Certificate of Analysis | May 09, 2023 | A105534 | |
| Certificate of Analysis | May 09, 2023 | A105534 | |
| Certificate of Analysis | May 09, 2023 | A105534 | |
| Certificate of Analysis | Dec 12, 2022 | A105534 | |
| Certificate of Analysis | Jan 18, 2022 | A105534 |
| Alternate Names | Aprotinin from bovine lung | CCG-270718 | APROTININ | Traskolan | Antilysin | J-200086 | Bovine Pancreatic Trypsin Inhibitor | AKOS024457997 | Traskolan|Bovine Pancreatic Trypsin Inhibitor |
|---|---|
| Reference |
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| 1. Liu Jing, Bai Xinpeng, Fu Pengcheng. (2022) In silico and in vitro assessment of bioactive peptides from Arthrospira platensis phycobiliproteins for DPP-IV inhibitory activity, ACE inhibitory activity, and antioxidant activity. JOURNAL OF APPLIED PHYCOLOGY, 34 (3): (1497-1511). |
| 2. Erdong Yuan, Shiying Nie, Chunli Qi, Bo Chang, Jiaoyan Ren. (2021) Effect of Scomberomorus niphonius peptide on the characteristics of resveratrol. Food & Function, 12 (22): (11449-11459). |
| 3. Fanglin Shen, Dan Li, Jianmin Chen. (2022) Mechanistic toxicity assessment of fine particulate matter emitted from fuel combustion via pathway-based approaches in human cells. SCIENCE OF THE TOTAL ENVIRONMENT, 806 (150214). |
| 4. Jiantao Ping, Wenli Wu, Lubin Qi, Jie Liu, Jinpeng Liu, Binglu Zhao, Quanbo Wang, Li Yu, Jin-Ming Lin, Qiongzheng Hu. (2021) Hydrogel-assisted paper-based lateral flow sensor for the detection of trypsin in human serum. BIOSENSORS & BIOELECTRONICS, 192 (113548). |
| 5. Jia-Yu Shi, Hai-Yan Pan, Kun Liu, Min Pan, Guo-Jun Si. (2020) Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 690 (108460). |
| 6. Jing Jin, Qiao‑Yun Hu, Wen‑Wen Xu, Wen‑Jia Zhu, Bei Liu, Jing Liu, Wei Wang, Hui‑Fang Zhou. (2019) Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary. Experimental and Therapeutic Medicine, 17 (5): (3501-3508). |
| 7. Yunhua Zhang, Jinyun Ji, Xiao Zhao, Ruoheng Jin, Jianhong Li, Hu Wan. (2017) Expression, purification and enzymatic properties of a β-N-acetylhexosaminidase from brown planthopper, Nilaparvata lugens. JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, 20 (1340). |
| 8. Dandan Zhou, Xiaoxiao Li, Wencun Liu, Mingjun Zhang, Ying Cheng, Zhousong Xu, Jian Gao, Yiyang Wang. (2025) A novel approach for engineering DHCM/GelMA microgels: application in hepatocellular carcinoma cell encapsulation and chemoresistance research. Frontiers in Bioengineering and Biotechnology, 13 |
| 9. Xiaoxiao Li, Weikang Zhao, Dandan Zhou, Pei Li, Chen Zhao, Qiang Zhou, Yiyang Wang. (2024) Construction of Integral Decellularized Cartilage Using a Novel Hydrostatic Pressure Bioreactor. Tissue Engineering Part C-Methods, 30 (3): (113-129). |
| 10. Ruixia Chen, Xiao-Chen Liu, Xianqi Yao, Wei Wang, Junyi Xiang, Igor Tomasevic, Weizheng Sun. (2024) Effects of high-pressure and CaCl2 pretreatments on the salt taste-enhancing activity of hydrolysate derived from spent hen meat. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, |
| 11. Feng Wu, Yili Xu, Chenyang Ji, Xue Li, Jue Shen, Yejie Fei, Guanghan Yuan, Hui Qian. (2025) Real-time global coagulation assay via ordered porous layer interferometry using silica colloidal crystal film. ANALYTICA CHIMICA ACTA, 1350 (343876). |