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Aprotinin from bovine lung - 3-8 TIU/mg, high purity , CAS No.9087-70-1, Inhibitor of plasminogen

In stock
Item Number
A105534
Grouped product items
SKU Size
Availability
Price Qty
A105534-5mg
5mg
3
$9.90
A105534-25mg
25mg
8
$37.90
A105534-50mg
50mg
3
$57.90
A105534-100mg
100mg
5
$102.90
A105534-250mg
250mg
3
$232.90
A105534-500mg
500mg
3
$418.90
A105534-1g
1g
3
$754.90

Competitive, reversible serine protease inhibitor.

Basic Description

Product Name Aprotinin from bovine lung - 3-8 TIU/mg, high purity , CAS No.9087-70-1
Synonyms Aprotinin from bovine lung | CCG-270718 | APROTININ | Traskolan | Antilysin | J-200086 | Bovine Pancreatic Trypsin Inhibitor | AKOS024457997 | Traskolan | Bovine Pancreatic Trypsin Inhibitor
Grade EnzymoPure™
Product Description

Aprotinin is a single chain polypeptide (58 amino-acids) crosslinked by three disulfide bridges, showing competitive and reversible inhibiton of proteolytic and esterolytic activity. Aprotinin forms stable complexes and blocks the active sites of serine protease enzymes. Binding is reversible with most aprotinin-protease complexes dissociating at pH >10 or < 3 (optimum pH 5-7); effective concentration is equimolar with protease. Used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones.
Aprotinin is largely used as an inhibitor of trypsin.

Specifications & Purity EnzymoPure™, 3-8 TIU/mg
Biochemical and Physiological Mechanisms Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Ap
Action Type INHIBITOR
Mechanism of action Inhibitor of plasminogen
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic Polymers
Class Polypeptides
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Polypeptides
Alternative Parents Cyclic peptides  Phenylalanine and derivatives  Pentacarboxylic acids and derivatives  Aspartic acid and derivatives  N-acyl-alpha amino acids  Proline and derivatives  Alpha amino acid amides  Alanine and derivatives  Amphetamines and derivatives  Pyrrolidinecarboxamides  N-acylpyrrolidines  1-hydroxy-2-unsubstituted benzenoids  N-acyl amines  Tertiary carboxylic acid amides  Secondary alcohols  Guanidines  Amino acids  Organic disulfides  Secondary carboxylic acid amides  Lactams  Primary carboxylic acid amides  Sulfenyl compounds  Azacyclic compounds  Carboximidamides  Carboxylic acids  Dialkylthioethers  Primary alcohols  Imines  Carbonyl compounds  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  Monoalkylamines  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Polypeptide - Cyclic alpha peptide - Phenylalanine or derivatives - Pentacarboxylic acid or derivatives - Aspartic acid or derivatives - N-acyl-alpha amino acid or derivatives - N-acyl-alpha-amino acid - Proline or derivatives - Alpha-amino acid amide - Alanine or derivatives - Amphetamine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Fatty acyl - Benzenoid - N-acyl-amine - Fatty amide - Pyrrolidine - Tertiary carboxylic acid amide - Organic disulfide - Amino acid or derivatives - Primary carboxylic acid amide - Carboxamide group - Amino acid - Secondary alcohol - Secondary carboxylic acid amide - Lactam - Guanidine - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Carboxylic acid - Dialkylthioether - Sulfenyl compound - Carboximidamide - Thioether - Hydrocarbon derivative - Organic oxide - Amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Alcohol - Imine - Primary aliphatic amine - Primary amine - Primary alcohol - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as polypeptides. These are peptides containing ten or more amino acid residues.
External Descriptors Not available

Associated Targets(Human)

PLG Tclin Plasminogen (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Storage and Shipping

Concentration 3-8 TIU/mg
Storage Temp Store at 2-8°C
Shipped In Wet ice
CAS 9087-70-1
Unit definition A trypsin inhibitor unit (TIU) can reduce the activity of two trypsin units by 50%, and one trypsin unit can hydrolyze 1.0 μ mol of N-α- benzoyl -DL- arginine p-nitroaniline per minute at pH 7.8 and 25℃. Another commonly used unit is KIU, and 1 TIU = 1,30

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

42 results found

Lot Number Certificate Type Date Item
B2216370 Certificate of Analysis Jul 14, 2025 A105534
B2216338 Certificate of Analysis Jul 14, 2025 A105534
B2216372 Certificate of Analysis Jul 14, 2025 A105534
E2516132 Certificate of Analysis May 09, 2025 A105534
E2516128 Certificate of Analysis May 09, 2025 A105534
E2516129 Certificate of Analysis May 09, 2025 A105534
E2516130 Certificate of Analysis May 09, 2025 A105534
E2516131 Certificate of Analysis May 09, 2025 A105534
E2516133 Certificate of Analysis May 09, 2025 A105534
C2521216 Certificate of Analysis Dec 26, 2024 A105534
C2521248 Certificate of Analysis Dec 26, 2024 A105534
C2521252 Certificate of Analysis Dec 26, 2024 A105534
C2521254 Certificate of Analysis Dec 26, 2024 A105534
C2521194 Certificate of Analysis Dec 26, 2024 A105534
H2422021 Certificate of Analysis Aug 08, 2024 A105534
H2422022 Certificate of Analysis Aug 08, 2024 A105534
H2422023 Certificate of Analysis Aug 08, 2024 A105534
H2422024 Certificate of Analysis Aug 08, 2024 A105534
F2215309 Certificate of Analysis Mar 08, 2024 A105534
F2215310 Certificate of Analysis Mar 08, 2024 A105534
F2215311 Certificate of Analysis Mar 08, 2024 A105534
F2215313 Certificate of Analysis Mar 08, 2024 A105534
F2215314 Certificate of Analysis Mar 08, 2024 A105534
F2215315 Certificate of Analysis Mar 08, 2024 A105534
C2401093 Certificate of Analysis Feb 21, 2024 A105534
C2401094 Certificate of Analysis Feb 21, 2024 A105534
B2216362 Certificate of Analysis Nov 13, 2023 A105534
K2324100 Certificate of Analysis Jul 05, 2023 A105534
I2216073 Certificate of Analysis Jul 05, 2023 A105534
I2216076 Certificate of Analysis Jul 05, 2023 A105534
I2216078 Certificate of Analysis Jul 05, 2023 A105534
I2216080 Certificate of Analysis Jul 05, 2023 A105534
I2216084 Certificate of Analysis Jul 05, 2023 A105534
I2216082 Certificate of Analysis Jul 05, 2023 A105534
I2216083 Certificate of Analysis Jul 05, 2023 A105534
G2131041 Certificate of Analysis May 09, 2023 A105534
G2131044 Certificate of Analysis May 09, 2023 A105534
G2131040 Certificate of Analysis May 09, 2023 A105534
G2131042 Certificate of Analysis May 09, 2023 A105534
G2131043 Certificate of Analysis May 09, 2023 A105534
B2105006 Certificate of Analysis Dec 12, 2022 A105534
B2216341 Certificate of Analysis Jan 18, 2022 A105534

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Genetic information

Alternate Names Aprotinin from bovine lung | CCG-270718 | APROTININ | Traskolan | Antilysin | J-200086 | Bovine Pancreatic Trypsin Inhibitor | AKOS024457997 | Traskolan|Bovine Pancreatic Trypsin Inhibitor
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

Citations of This Product

1. Liu Jing, Bai Xinpeng, Fu Pengcheng.  (2022)  In silico and in vitro assessment of bioactive peptides from Arthrospira platensis phycobiliproteins for DPP-IV inhibitory activity, ACE inhibitory activity, and antioxidant activity.  JOURNAL OF APPLIED PHYCOLOGY,  34  (3): (1497-1511). 
2. Erdong Yuan, Shiying Nie, Chunli Qi, Bo Chang, Jiaoyan Ren.  (2021)  Effect of Scomberomorus niphonius peptide on the characteristics of resveratrol.  Food & Function,  12  (22): (11449-11459). 
3. Fanglin Shen, Dan Li, Jianmin Chen.  (2022)  Mechanistic toxicity assessment of fine particulate matter emitted from fuel combustion via pathway-based approaches in human cells.  SCIENCE OF THE TOTAL ENVIRONMENT,  806  (150214). 
4. Jiantao Ping, Wenli Wu, Lubin Qi, Jie Liu, Jinpeng Liu, Binglu Zhao, Quanbo Wang, Li Yu, Jin-Ming Lin, Qiongzheng Hu.  (2021)  Hydrogel-assisted paper-based lateral flow sensor for the detection of trypsin in human serum.  BIOSENSORS & BIOELECTRONICS,  192  (113548). 
5. Jia-Yu Shi, Hai-Yan Pan, Kun Liu, Min Pan, Guo-Jun Si.  (2020)  Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,  690  (108460). 
6. Jing Jin, Qiao‑Yun Hu, Wen‑Wen Xu, Wen‑Jia Zhu, Bei Liu, Jing Liu, Wei Wang, Hui‑Fang Zhou.  (2019)  Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary.  Experimental and Therapeutic Medicine,  17  (5): (3501-3508). 
7. Yunhua Zhang, Jinyun Ji, Xiao Zhao, Ruoheng Jin, Jianhong Li, Hu Wan.  (2017)  Expression, purification and enzymatic properties of a β-N-acetylhexosaminidase from brown planthopper, Nilaparvata lugens.  JOURNAL OF ASIA-PACIFIC ENTOMOLOGY,  20  (1340). 
8. Dandan Zhou, Xiaoxiao Li, Wencun Liu, Mingjun Zhang, Ying Cheng, Zhousong Xu, Jian Gao, Yiyang Wang.  (2025)  A novel approach for engineering DHCM/GelMA microgels: application in hepatocellular carcinoma cell encapsulation and chemoresistance research.  Frontiers in Bioengineering and Biotechnology,  13   
9. Xiaoxiao Li, Weikang Zhao, Dandan Zhou, Pei Li, Chen Zhao, Qiang Zhou, Yiyang Wang.  (2024)  Construction of Integral Decellularized Cartilage Using a Novel Hydrostatic Pressure Bioreactor.  Tissue Engineering Part C-Methods,  30  (3): (113-129). 
10. Ruixia Chen, Xiao-Chen Liu, Xianqi Yao, Wei Wang, Junyi Xiang, Igor Tomasevic, Weizheng Sun.  (2024)  Effects of high-pressure and CaCl2 pretreatments on the salt taste-enhancing activity of hydrolysate derived from spent hen meat.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,     
11. Feng Wu, Yili Xu, Chenyang Ji, Xue Li, Jue Shen, Yejie Fei, Guanghan Yuan, Hui Qian.  (2025)  Real-time global coagulation assay via ordered porous layer interferometry using silica colloidal crystal film.  ANALYTICA CHIMICA ACTA,  1350  (343876). 

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