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ANT3310 sodium - 10mM in DMSO, high purity , CAS No.2410688-61-6(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 2410688-61-6(DMSO)
Molecular Weight: 262.19

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Item Number

A655994

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SKU	Size	Availability	Price	Qty
A655994-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$110.90

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Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	ANT3310 sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC 50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). ANT3310 sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobactera
Storage Temp	Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	ANT3310 sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC 50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). ANT3310 sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). ANT3310 sodium can be used in the research of bacterial infection. In Vitro ANT3310 sodium (Compound 21, 0.006 to 3 000 nM, 10 min) inhibits a series of Serine β-Lactamase (AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2), with IC <>50 values ranging from 1 nM to 175 nM. ANT3310 sodium shows a low in vitro cytotoxicity (IC <>50 : > 100 μM) in HepG2 cell, cardiotoxicity (inhibition of the hERG potassium ion channel), and genotoxicity (Ames test). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo ANT3310 sodium (intravenous injection, 25-100 mg/kg, at 1, 3, 5, and 7 h postinfection) reduces bacterial burdens in murine thigh infection model . ANT3310 sodium (intravenous injection, 1 mg/kg, Male Swiss albino mice) shows a T 1/2 value of 0.64 h, AUC value of 412 ng•h/mL, and Cl value of 40 mL/min/kg (pharmacokinetic assay) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Murine thigh infection model Dosage: 25, 50, and 100 mg/kg Administration: Intravenous injection, at 1, 3, 5, and 7 h postinfection Result: Reduced bacterial burdens (colony forming units, CFU) in a dose-dependent manner to levels below that of the initial starting inoculum at the highest dose, when treated with the combination of MEM.

Names and Identifiers

Smiles	O=S(ON1[C@H]2C[N@]([C@@H](CC2)F)C1=O)(O[Na])=O
Molecular Weight	262.19

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