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Signaling Pathways
Apoptosis
Apoptosis
AKN-028 , CAS No.1175017-90-9, Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase

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AKN-028 , CAS No.1175017-90-9, Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase

COA

Grade & Purity:

Moligand™

Cas Number: 1175017-90-9
PubChem CID: 44177328

In stock

Item Number

A607474

Grouped product items
SKU	Size	Availability	Price	Qty
A607474-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607474-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

Apoptosis (4276) fms related receptor tyrosine kinase 3 Inhibitor (60) Intrinsic Pathway (690) KIT proto-oncogene，receptor tyrosine kinase Inhibitor (51) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms	AKN028 \| AKN-028 \| Y66IS3CS0R \| AKOS040756521 \| 2,3-Pyrazinediamine, N3-1H-indol-5-yl-5-(4-pyridinyl)- \| 1175017-90-9 \| UNII-Y66IS3CS0R \| DB12746 \| N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine \| 3-N-(1H-indol-5-yl)-5-pyridin-4-ylpyrazine-2,3-di
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of KIT proto-oncogene; receptor tyrosine kinase

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass Indoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	Indoles
Intermediate Tree Nodes	Not available
Direct Parent	Indoles
Alternative Parents	Aminopyrazines Pyridines and derivatives Imidolactams Benzenoids Pyrroles Heteroaromatic compounds Secondary amines Azacyclic compounds Primary amines Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Indole - Aminopyrazine - Pyrazine - Imidolactam - Benzenoid - Pyridine - Heteroaromatic compound - Pyrrole - Azacycle - Secondary amine - Primary amine - Organonitrogen compound - Hydrocarbon derivative - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 (1 Activities)

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit (1 Activities)

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-N-(1H-indol-5-yl)-5-pyridin-4-ylpyrazine-2,3-diamine
INCHI	InChI=1S/C17H14N6/c18-16-17(22-13-1-2-14-12(9-13)5-8-20-14)23-15(10-21-16)11-3-6-19-7-4-11/h1-10,20H,(H2,18,21)(H,22,23)
InChIKey	JLRIJKVMMZEKDF-UHFFFAOYSA-N
Smiles	Nc1ncc(nc1Nc1ccc2c(c1)cc[nH]2)c1ccncc1
Isomeric SMILES	C1=CC2=C(C=CN2)C=C1NC3=NC(=CN=C3N)C4=CC=NC=C4
PubChem CID	44177328

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Molecular Weight	302.330 g/mol
XLogP3	2.000
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	302.128 Da
Monoisotopic Mass	302.128 Da
Topological Polar Surface Area	92.500 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	385.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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