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AG 1478 hydrochloride - 98%, high purity , CAS No.170449-18-0

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AG 1478 hydrochloride - 98%, high purity , CAS No.170449-18-0

COA

Grade & Purity:

≥98%

Cas Number: 170449-18-0
Molecular Weight: 352.22
PubChem CID: 3035187

In stock

Item Number

A287390

Grouped product items
SKU	Size	Availability	Price
A287390-5mg	5mg	3	$113.90
A287390-10mg	10mg	3	$174.90
A287390-25mg	25mg	3	$393.90
A287390-50mg	50mg	3	$714.90
A287390-100mg	100mg	2	$1,285.90
A287390-200mg	200mg	2	$2,314.90

Highly potent EGFR-kinase inhibitor

View related series

Anti-infection (2803) EGFR (254) HCV (160) Influenza Virus (253) JAK/STAT Signaling (507) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260) Virus (1811)

Basic Description

Synonyms	AG 1478 HYDROCHLORIDE \| AG-1478.hcl \| 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-, monohydrochloride \| DS-13538 \| MLS000758209 \| AG 1478 HCl \| AG1478 HCl \| AG-1478 HCl \| BCPP000425 \| Tyrphostin AG-1478 hydrochloride;AG 1478 hydrochloride;NSC 6932
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Potent and selective inhibitor of epidermal growth factor receptor kinase (IC50values 3 nM for EGFR and > 100μM for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cellsin vitro(IC50= 1μM).
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazanaphthalenes
    - Subclass Benzodiazines
      - Level5 Quinazolines
        Level6 Quinazolinamines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazanaphthalenes
Subclass	Benzodiazines
Intermediate Tree Nodes	Quinazolines
Direct Parent	Quinazolinamines
Alternative Parents	Anisoles Aniline and substituted anilines Chlorobenzenes Aminopyrimidines and derivatives Alkyl aryl ethers Imidolactams Aryl chlorides Heteroaromatic compounds Azacyclic compounds Organochlorides Hydrochlorides Hydrocarbon derivatives Amines
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Quinazolinamine - Anisole - Aniline or substituted anilines - Phenol ether - Alkyl aryl ether - Aminopyrimidine - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Pyrimidine - Imidolactam - Benzenoid - Heteroaromatic compound - Azacycle - Ether - Organochloride - Organohalogen compound - Organic oxygen compound - Amine - Organonitrogen compound - Organooxygen compound - Hydrochloride - Hydrocarbon derivative - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

EGFR Tclin Epidermal growth factor receptor (2 Activities)

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)

Discover Target: LCK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride
INCHI	InChI=1S/C16H14ClN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H
InChIKey	WDJDYIUSDDVWKB-UHFFFAOYSA-N
Smiles	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC.Cl
Isomeric SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC.Cl
Molecular Weight	352.22
Reaxy-Rn	7452865
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7452865&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C2321877	Certificate of Analysis	Jan 03, 2023	A287390
C2321116	Certificate of Analysis	Jan 03, 2023	A287390
C2321152	Certificate of Analysis	Jan 03, 2023	A287390
C2321206	Certificate of Analysis	Jan 03, 2023	A287390
C2321810	Certificate of Analysis	Jan 03, 2023	A287390
C2321854	Certificate of Analysis	Jan 03, 2023	A287390

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 3.52, Max Conc. mM: 10 with gentle warming
Molecular Weight	352.200 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	351.054 Da
Monoisotopic Mass	351.054 Da
Topological Polar Surface Area	56.300 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	360.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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